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- Publisher Website: 10.1053/jpsu.2001.23979
- Scopus: eid_2-s2.0-0034982336
- PMID: 11381429
- WOS: WOS:000169050300024
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Article: Enteric nervous system, interstitial cells of Cajal, and smooth muscle vacuolization in segmental dilatation of jejunum
Title | Enteric nervous system, interstitial cells of Cajal, and smooth muscle vacuolization in segmental dilatation of jejunum |
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Authors | |
Keywords | C-kit Interstitial cell of Cajal Microtubule-associated protein Neural markers Ret protein S100 protein Segmental dilatation Small bowel |
Issue Date | 2001 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg |
Citation | Journal Of Pediatric Surgery, 2001, v. 36 n. 6, p. 930-935 How to Cite? |
Abstract | Background/Purpose: The etiology of congenital segmental dilatation (CSD) of bowel remains elusive. Intestitial cell of Cajal plays a role in the pace making of the intestine. Its abnormality has been documented in a variety of conditions of abnormal intestinal motility. The current study attempts to evaluate the roles of intestitial cells of Cajal, enteric nervous system, and smooth muscle in segmental dilatation of small bowel. Methods: Resected specimen from a neonate with segmental dilatation of jejunum was stained with H&E, Alcian blue, Periodic Acid-Schiff (PAS), and immunostained with S100, Ret, MAP5, and c-kit antibodies using the standard immunohistochemical process. Results: The immunostaining of S100, Ret, MAP5 and c-kit of CSD specimen were positive. Localized vacuolization was, however, detected in the circular smooth muscle of the jejunum. The Alcian blue and PAS staining of the vacuolization were negative. Conclusions: CSD shows no abnormality in the enteric nervous system and pace makers. Localized vacuolization suggests myopathy to be a contributing factor to the disease. Copyright © 2001 by W.B. Saunders Company. |
Persistent Identifier | http://hdl.handle.net/10722/83504 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheng, W | en_HK |
dc.contributor.author | Lui, VCH | en_HK |
dc.contributor.author | Chen, QM | en_HK |
dc.contributor.author | Tam, PKH | en_HK |
dc.date.accessioned | 2010-09-06T08:41:49Z | - |
dc.date.available | 2010-09-06T08:41:49Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | Journal Of Pediatric Surgery, 2001, v. 36 n. 6, p. 930-935 | en_HK |
dc.identifier.issn | 0022-3468 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/83504 | - |
dc.description.abstract | Background/Purpose: The etiology of congenital segmental dilatation (CSD) of bowel remains elusive. Intestitial cell of Cajal plays a role in the pace making of the intestine. Its abnormality has been documented in a variety of conditions of abnormal intestinal motility. The current study attempts to evaluate the roles of intestitial cells of Cajal, enteric nervous system, and smooth muscle in segmental dilatation of small bowel. Methods: Resected specimen from a neonate with segmental dilatation of jejunum was stained with H&E, Alcian blue, Periodic Acid-Schiff (PAS), and immunostained with S100, Ret, MAP5, and c-kit antibodies using the standard immunohistochemical process. Results: The immunostaining of S100, Ret, MAP5 and c-kit of CSD specimen were positive. Localized vacuolization was, however, detected in the circular smooth muscle of the jejunum. The Alcian blue and PAS staining of the vacuolization were negative. Conclusions: CSD shows no abnormality in the enteric nervous system and pace makers. Localized vacuolization suggests myopathy to be a contributing factor to the disease. Copyright © 2001 by W.B. Saunders Company. | en_HK |
dc.language | eng | en_HK |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg | en_HK |
dc.relation.ispartof | Journal of Pediatric Surgery | en_HK |
dc.subject | C-kit | en_HK |
dc.subject | Interstitial cell of Cajal | en_HK |
dc.subject | Microtubule-associated protein | en_HK |
dc.subject | Neural markers | en_HK |
dc.subject | Ret protein | en_HK |
dc.subject | S100 protein | en_HK |
dc.subject | Segmental dilatation | en_HK |
dc.subject | Small bowel | en_HK |
dc.title | Enteric nervous system, interstitial cells of Cajal, and smooth muscle vacuolization in segmental dilatation of jejunum | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3468&volume=36&issue=6&spage=930&epage=935&date=2001&atitle=Enteric+nervous+system,+interstitial+cells+of+cajal,+and+smooth+muscle+vacuolization+in+segmental+dilatation+of+jejunum | en_HK |
dc.identifier.email | Lui, VCH: vchlui@hkucc.hku.hk | en_HK |
dc.identifier.email | Tam, PKH: paultam@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lui, VCH=rp00363 | en_HK |
dc.identifier.authority | Tam, PKH=rp00060 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1053/jpsu.2001.23979 | en_HK |
dc.identifier.pmid | 11381429 | - |
dc.identifier.scopus | eid_2-s2.0-0034982336 | en_HK |
dc.identifier.hkuros | 58963 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034982336&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 36 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 930 | en_HK |
dc.identifier.epage | 935 | en_HK |
dc.identifier.isi | WOS:000169050300024 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Cheng, W=7402169228 | en_HK |
dc.identifier.scopusauthorid | Lui, VCH=7004231344 | en_HK |
dc.identifier.scopusauthorid | Chen, QM=16244214800 | en_HK |
dc.identifier.scopusauthorid | Tam, PKH=7202539421 | en_HK |
dc.identifier.issnl | 0022-3468 | - |