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- Publisher Website: 10.1016/j.ccr.2008.01.013
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- PMID: 18242515
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Article: Significance of CD90+ Cancer Stem Cells in Human Liver Cancer
Title | Significance of CD90+ Cancer Stem Cells in Human Liver Cancer |
---|---|
Authors | |
Keywords | CELLCYCLE STEMCELL |
Issue Date | 2008 |
Publisher | Cell Press. The Journal's web site is located at http://www.elsevier.com/locate/ccell |
Citation | Cancer Cell, 2008, v. 13 n. 2, p. 153-166 How to Cite? |
Abstract | This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90- cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45-CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44- counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90+ cells. Differential gene expression profiles were identified in the CD45-CD90+ and CD45-CD90- cells isolated from tissue and blood samples from liver cancer patients and controls. © 2008 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/84403 |
ISSN | 2023 Impact Factor: 48.8 2023 SCImago Journal Rankings: 17.507 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, ZF | en_HK |
dc.contributor.author | Ho, DW | en_HK |
dc.contributor.author | Ng, MN | en_HK |
dc.contributor.author | Lau, CK | en_HK |
dc.contributor.author | Yu, WC | en_HK |
dc.contributor.author | Ngai, P | en_HK |
dc.contributor.author | Chu, PWK | en_HK |
dc.contributor.author | Lam, CT | en_HK |
dc.contributor.author | Poon, RTP | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.date.accessioned | 2010-09-06T08:52:32Z | - |
dc.date.available | 2010-09-06T08:52:32Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Cancer Cell, 2008, v. 13 n. 2, p. 153-166 | en_HK |
dc.identifier.issn | 1535-6108 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/84403 | - |
dc.description.abstract | This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90- cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45-CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44- counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90+ cells. Differential gene expression profiles were identified in the CD45-CD90+ and CD45-CD90- cells isolated from tissue and blood samples from liver cancer patients and controls. © 2008 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Cell Press. The Journal's web site is located at http://www.elsevier.com/locate/ccell | en_HK |
dc.relation.ispartof | Cancer Cell | en_HK |
dc.subject | CELLCYCLE | en_HK |
dc.subject | STEMCELL | en_HK |
dc.title | Significance of CD90+ Cancer Stem Cells in Human Liver Cancer | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1535-6108&volume=13&issue=2&spage=153&epage=166&date=2008&atitle=Significance+of+CD90++cancer+stem+cells+in+human+liver+cancer | en_HK |
dc.identifier.email | Poon, RTP: poontp@hkucc.hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.authority | Poon, RTP=rp00446 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.ccr.2008.01.013 | en_HK |
dc.identifier.pmid | 18242515 | - |
dc.identifier.scopus | eid_2-s2.0-38549139140 | en_HK |
dc.identifier.hkuros | 140749 | en_HK |
dc.identifier.hkuros | 166238 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-38549139140&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 13 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 153 | en_HK |
dc.identifier.epage | 166 | en_HK |
dc.identifier.eissn | 1878-3686 | - |
dc.identifier.isi | WOS:000253026200010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Yang, ZF=14018809600 | en_HK |
dc.identifier.scopusauthorid | Ho, DW=7402971906 | en_HK |
dc.identifier.scopusauthorid | Ng, MN=23478329500 | en_HK |
dc.identifier.scopusauthorid | Lau, CK=7401968442 | en_HK |
dc.identifier.scopusauthorid | Yu, WC=37022285400 | en_HK |
dc.identifier.scopusauthorid | Ngai, P=23477971900 | en_HK |
dc.identifier.scopusauthorid | Chu, PWK=7402159518 | en_HK |
dc.identifier.scopusauthorid | Lam, CT=7402989860 | en_HK |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.issnl | 1535-6108 | - |