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Article: Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes

TitleProtein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes
Authors
KeywordsGenistein
Ion channels
Potassium currents
Protein tyrosine kinase
Rat ventricular myocytes
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsig
Citation
Cellular Signalling, 2004, v. 16 n. 3, p. 333-341 How to Cite?
AbstractEffects of the isoflavone protein tyrosine kinase (PTK) inhibitor genistein on voltage-dependent K + currents, i.e., transient outward K + current (I to), sustained K + current (I ss), and inward rectifier K + current (I K1) were studied in rat cardiac ventricular myocytes. It was found that I to was reversibly inhibited by genistein in a concentration- dependent manner (IC 50=28.1 μM), while I ss was suppressed by genistein with IC 50 of 18.5 μM. In addition, I K1 (at -50 mV) was significantly decreased by 36.3±4.4% with 25 μM genistein. The inhibition of I to, I ss, and I K1 by genistein was significantly reversed by the application of the protein tyrosine phosphatase inhibitor sodium orthovanadate (1 mM). However, I to, I ss, and I K1 were not affected by the non-isoflavone PTK inhibitor tyrphostin A23 (100 μM) and PP2 (1 μM). These results indicate that activation of I to, I ss, and I K1 channels is modulated by genistein-sensitive PTKs in rat ventricular myocytes. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/85477
ISSN
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 1.317
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGao, Zen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorWong, TMen_HK
dc.contributor.authorLi, GRen_HK
dc.date.accessioned2010-09-06T09:05:31Z-
dc.date.available2010-09-06T09:05:31Z-
dc.date.issued2004en_HK
dc.identifier.citationCellular Signalling, 2004, v. 16 n. 3, p. 333-341en_HK
dc.identifier.issn0898-6568en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85477-
dc.description.abstractEffects of the isoflavone protein tyrosine kinase (PTK) inhibitor genistein on voltage-dependent K + currents, i.e., transient outward K + current (I to), sustained K + current (I ss), and inward rectifier K + current (I K1) were studied in rat cardiac ventricular myocytes. It was found that I to was reversibly inhibited by genistein in a concentration- dependent manner (IC 50=28.1 μM), while I ss was suppressed by genistein with IC 50 of 18.5 μM. In addition, I K1 (at -50 mV) was significantly decreased by 36.3±4.4% with 25 μM genistein. The inhibition of I to, I ss, and I K1 by genistein was significantly reversed by the application of the protein tyrosine phosphatase inhibitor sodium orthovanadate (1 mM). However, I to, I ss, and I K1 were not affected by the non-isoflavone PTK inhibitor tyrphostin A23 (100 μM) and PP2 (1 μM). These results indicate that activation of I to, I ss, and I K1 channels is modulated by genistein-sensitive PTKs in rat ventricular myocytes. © 2003 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsigen_HK
dc.relation.ispartofCellular Signallingen_HK
dc.rightsCellular Signalling. Copyright © Elsevier Inc.en_HK
dc.subjectGenistein-
dc.subjectIon channels-
dc.subjectPotassium currents-
dc.subjectProtein tyrosine kinase-
dc.subjectRat ventricular myocytes-
dc.subject.meshAnimalsen_HK
dc.subject.meshEnzyme Inhibitors - pharmacologyen_HK
dc.subject.meshGenistein - pharmacologyen_HK
dc.subject.meshHeart Ventricles - cytology - metabolismen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshMyocytes, Cardiac - metabolismen_HK
dc.subject.meshPotassium Channels, Voltage-Gated - metabolismen_HK
dc.subject.meshProtein-Tyrosine Kinases - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshVanadates - pharmacologyen_HK
dc.titleProtein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0898-6568&volume=16&issue=3&spage=333&epage=341&date=2004&atitle=Protein+tyrosine+kinase-dependent+modulation+of+voltage-dependent+potassium+channels+by+genistein+in+rat+cardiac+ventricular+myocytesen_HK
dc.identifier.emailLi, GR:grli@hkucc.hku.hken_HK
dc.identifier.authorityLi, GR=rp00476en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cellsig.2003.08.003en_HK
dc.identifier.pmid14687663-
dc.identifier.scopuseid_2-s2.0-0347627268en_HK
dc.identifier.hkuros88554en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347627268&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage333en_HK
dc.identifier.epage341en_HK
dc.identifier.isiWOS:000187967900005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGao, Z=16549711200en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridWong, TM=7403531434en_HK
dc.identifier.scopusauthoridLi, GR=7408462932en_HK
dc.identifier.issnl0898-6568-

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