File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma

TitleCorrelation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma
Authors
KeywordsBasic fibroblast growth factor
Hepatocellular carcinoma
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurg
Citation
American Journal Of Surgery, 2001, v. 182 n. 3, p. 298-304 How to Cite?
AbstractBackground: Basic fibroblast growth factor (bFGF) is an important positive regulator of tumor angiogenesis. This study evaluated the role of serum bFGF as a biological marker of tumor invasiveness and postresection recurrence in hepatocellular carcinoma (HCC). Methods: Concentrations of bFGF in preoperative serum samples in 88 patients undergoing resection of HCC were measured by a quantitative enzyme-linked immunosorbent assay. A single pathologist performed histopathologic examination of all tumor specimens. All patients were prospectively monitored for tumor recurrence. Results: The preoperative serum bFGF levels ranged from <0.22 to 71.2 pg/mL (median 10.8 pg/mL). There was significant correlation between high serum bFGF levels and large tumor >5 cm, presence of venous invasion or advanced pTNM stage. Patients with a serum bFGF level >10.8 pg/mL had worse disease-free survival than those with a level <10.8 pg/mL (median disease-free survival 11.2 versus 20 months, P=0.044). Serum bFGF level >10.8 pg/mL (P=0.035) and tumor size >5 cm (P=0.004) were independent preoperative factors that predicted early recurrence after resection of HCC. Conclusions: This study supports a role of bFGF in tumor growth and invasion in HCC. A high preoperative serum bFGF level appears to be predictive of invasive tumor and early postoperative recurrence. The clinical implications of serum bFGF level in HCC warrant further investigation. © 2001 Excerpta Medica, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/88413
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.897
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorLau, Cen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-06T09:43:03Z-
dc.date.available2010-09-06T09:43:03Z-
dc.date.issued2001en_HK
dc.identifier.citationAmerican Journal Of Surgery, 2001, v. 182 n. 3, p. 298-304en_HK
dc.identifier.issn0002-9610en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88413-
dc.description.abstractBackground: Basic fibroblast growth factor (bFGF) is an important positive regulator of tumor angiogenesis. This study evaluated the role of serum bFGF as a biological marker of tumor invasiveness and postresection recurrence in hepatocellular carcinoma (HCC). Methods: Concentrations of bFGF in preoperative serum samples in 88 patients undergoing resection of HCC were measured by a quantitative enzyme-linked immunosorbent assay. A single pathologist performed histopathologic examination of all tumor specimens. All patients were prospectively monitored for tumor recurrence. Results: The preoperative serum bFGF levels ranged from <0.22 to 71.2 pg/mL (median 10.8 pg/mL). There was significant correlation between high serum bFGF levels and large tumor >5 cm, presence of venous invasion or advanced pTNM stage. Patients with a serum bFGF level >10.8 pg/mL had worse disease-free survival than those with a level <10.8 pg/mL (median disease-free survival 11.2 versus 20 months, P=0.044). Serum bFGF level >10.8 pg/mL (P=0.035) and tumor size >5 cm (P=0.004) were independent preoperative factors that predicted early recurrence after resection of HCC. Conclusions: This study supports a role of bFGF in tumor growth and invasion in HCC. A high preoperative serum bFGF level appears to be predictive of invasive tumor and early postoperative recurrence. The clinical implications of serum bFGF level in HCC warrant further investigation. © 2001 Excerpta Medica, Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjsurgen_HK
dc.relation.ispartofAmerican Journal of Surgeryen_HK
dc.rightsThe American Journal of Surgery. Copyright © Elsevier Inc.en_HK
dc.subjectBasic fibroblast growth factoren_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subject.meshCarcinoma, Hepatocellular - blood - mortality - pathology - surgeryen_HK
dc.subject.meshDisease-Free Survivalen_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshFibroblast Growth Factor 2 - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver Neoplasms - blood - mortality - pathology - surgeryen_HK
dc.subject.meshNeoplasm Invasivenessen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshTumor Markers, Biological - blooden_HK
dc.titleCorrelation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9610&volume=182&issue=3&spage=298&epage=304&date=2001&atitle=Correlation+of+serum+basic+fibroblast+growth+factor+levels+with+clinicopathologic+features+and+postoperative+recurrence+in+hepatocellular+carcinomaen_HK
dc.identifier.emailPoon, RTP: poontp@hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0002-9610(01)00708-5en_HK
dc.identifier.pmid11587697-
dc.identifier.scopuseid_2-s2.0-0034802560en_HK
dc.identifier.hkuros66020en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034802560&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume182en_HK
dc.identifier.issue3en_HK
dc.identifier.spage298en_HK
dc.identifier.epage304en_HK
dc.identifier.isiWOS:000171488900020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridLau, C=8086563300en_HK
dc.identifier.scopusauthoridYu, WC=24490445800en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.issnl0002-9610-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats