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- Publisher Website: 10.1016/S0046-8177(96)90401-3
- Scopus: eid_2-s2.0-0030013623
- PMID: 8698315
- WOS: WOS:A1996UW74400014
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Article: Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin
Title | Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin |
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Authors | |
Keywords | gene rearrangement gene transcription nasal lymphomas natural killer cells T-cell receptor |
Issue Date | 1996 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath |
Citation | Human Pathology, 1996, v. 27 n. 7, p. 701-707 How to Cite? |
Abstract | Although nasal lymphomas showing midfacial destructive lesions had been classified as T-cell lymphomas, their exact cellular origin is still unclear. Although they usually express a restricted number of T-cell-related antigens, namely, CD2, CD43, and CD45RO, other pan-T or subset-T-lineage antigens, such as CD3 (membrane), CD5, CD4, CD8, and CD7, are frequently absent. Conversely, they often express a natural killer (NK) cell-associated antigen, CD56, but lack other mature NK markers. To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data. Two cases of nasal lymphomas with CD2+CD3(Leu4)-CD19- CD56+ phenotype were shown to express truncated 1.0-kb T(β) and multiple unrearranged T(δ) transcripts with germline TCR β, γ, δ, and immunoglobulin heavy-chain joining region (J(H)) genes, consistent with NK cell lineage. In contrast, one case of nasal lymphoma with CD2tCD3(Leu4)+CD8+CD19-CD56+ phenotype expressed full-length T(α), T(β), and T(γ) transcriptswith rearranged TCR β, γ, and deleted TCR δ genes, indicating T-cell lineage. These results support the view that nasal lymphomas can be separated into NK-cell and T-cell neoplasms, based on differences in genotypic characteristics. The possibility of these tumors being derived from a putative common precursor cell merits further investigation. |
Persistent Identifier | http://hdl.handle.net/10722/88612 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.936 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chiang, AKS | en_HK |
dc.contributor.author | Srivastava, G | en_HK |
dc.contributor.author | Lau, PWF | en_HK |
dc.contributor.author | Ho, FCS | en_HK |
dc.date.accessioned | 2010-09-06T09:45:40Z | - |
dc.date.available | 2010-09-06T09:45:40Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | Human Pathology, 1996, v. 27 n. 7, p. 701-707 | en_HK |
dc.identifier.issn | 0046-8177 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/88612 | - |
dc.description.abstract | Although nasal lymphomas showing midfacial destructive lesions had been classified as T-cell lymphomas, their exact cellular origin is still unclear. Although they usually express a restricted number of T-cell-related antigens, namely, CD2, CD43, and CD45RO, other pan-T or subset-T-lineage antigens, such as CD3 (membrane), CD5, CD4, CD8, and CD7, are frequently absent. Conversely, they often express a natural killer (NK) cell-associated antigen, CD56, but lack other mature NK markers. To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data. Two cases of nasal lymphomas with CD2+CD3(Leu4)-CD19- CD56+ phenotype were shown to express truncated 1.0-kb T(β) and multiple unrearranged T(δ) transcripts with germline TCR β, γ, δ, and immunoglobulin heavy-chain joining region (J(H)) genes, consistent with NK cell lineage. In contrast, one case of nasal lymphoma with CD2tCD3(Leu4)+CD8+CD19-CD56+ phenotype expressed full-length T(α), T(β), and T(γ) transcriptswith rearranged TCR β, γ, and deleted TCR δ genes, indicating T-cell lineage. These results support the view that nasal lymphomas can be separated into NK-cell and T-cell neoplasms, based on differences in genotypic characteristics. The possibility of these tumors being derived from a putative common precursor cell merits further investigation. | en_HK |
dc.language | eng | en_HK |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath | en_HK |
dc.relation.ispartof | Human Pathology | en_HK |
dc.subject | gene rearrangement | en_HK |
dc.subject | gene transcription | en_HK |
dc.subject | nasal lymphomas | en_HK |
dc.subject | natural killer cells | en_HK |
dc.subject | T-cell receptor | en_HK |
dc.subject.mesh | Gene Rearrangement, T-Lymphocyte | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Killer Cells, Natural - immunology - pathology | en_HK |
dc.subject.mesh | Lymphoma - genetics - immunology - pathology | en_HK |
dc.subject.mesh | Lymphoma, T-Cell - genetics - immunology - pathology | en_HK |
dc.subject.mesh | Nose Neoplasms - genetics - immunology - pathology | en_HK |
dc.subject.mesh | Phenotype | en_HK |
dc.subject.mesh | Receptors, Antigen, T-Cell - genetics | en_HK |
dc.subject.mesh | Transcription, Genetic | en_HK |
dc.title | Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=27&issue=7&spage=701&epage=707&date=1996&atitle=Differences+in+T-Cell-Receptor+Gene+Rearrangement+and+Transcription+in+Nasal+Lymphomas+of+Natural+Killer+and+T-Cell+Types:+Implications+On+Cellular+Origin | en_HK |
dc.identifier.email | Chiang, AKS:chiangak@hkucc.hku.hk | en_HK |
dc.identifier.email | Srivastava, G:gopesh@pathology.hku.hk | en_HK |
dc.identifier.authority | Chiang, AKS=rp00403 | en_HK |
dc.identifier.authority | Srivastava, G=rp00365 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0046-8177(96)90401-3 | en_HK |
dc.identifier.pmid | 8698315 | en_HK |
dc.identifier.scopus | eid_2-s2.0-0030013623 | en_HK |
dc.identifier.hkuros | 56484 | en_HK |
dc.identifier.hkuros | 26056 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030013623&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 27 | en_HK |
dc.identifier.issue | 7 | en_HK |
dc.identifier.spage | 701 | en_HK |
dc.identifier.epage | 707 | en_HK |
dc.identifier.isi | WOS:A1996UW74400014 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Chiang, AKS=7101623534 | en_HK |
dc.identifier.scopusauthorid | Srivastava, G=7202242238 | en_HK |
dc.identifier.scopusauthorid | Lau, PWF=7102543475 | en_HK |
dc.identifier.scopusauthorid | Ho, FCS=7103408147 | en_HK |
dc.identifier.issnl | 0046-8177 | - |