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Article: Prodepin: A new product of the adrenomedullin (ADM) gene has systemic vasodilator activity

TitleProdepin: A new product of the adrenomedullin (ADM) gene has systemic vasodilator activity
Authors
Lippton, HGao, YLin, BHeaton, JFerrara, JDeVito, MGranger, TPigott, JChang, J-KHyman, A
KeywordsSpecies Index: Animalia
Canis Familiaris
Felis Catus
Oryctolagus Cuniculus
Sus Scrofa
Issue Date1994
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1994, v. 54 n. 23, p. PL409-PL412 How to Cite?
DOI: http://dx.doi.org/10.1016/0024-3205(94)90124-4
AbstractThe purpose of the present study was to investigate the effects of products of the ADM gene other than ADM on systemic hemodynamics in the anesthetized rat, rabbit, piglet, cat and dog. Bolus intravenous (i.v.) injections of rat proADM22-41 (3-30μg) significantly decreased systemic arterial pressure (SAP) and systemic vascular resistance in the anesthetized rat. Unlike ADM, rat proADM22-41 markedly increased cardiac output in the rat. Bolus i.v. injections of human proADM22-41 up to 500μg had not effect in all species studied and rat proADM22-41 had no effect in species other than the rat. The present data suggest that rat proADM22- 41 is a novel product of the ADM gene other than ADM and possesses marked systemic vasodilator activity. The present data also suggest that the hemodynamic activity of this peptide is species specific.
Persistent Identifierhttp://hdl.handle.net/10722/90770
ISSN
0024-3205
2023 Impact Factor: 5.2
2023 SCImago Journal Rankings: 1.257
ISI Accession Number ID
WOS:A1994NJ35000012

 

DC FieldValueLanguage
dc.contributor.authorLippton, Hen_HK
dc.contributor.authorGao, Yen_HK
dc.contributor.authorLin, Ben_HK
dc.contributor.authorHeaton, Jen_HK
dc.contributor.authorFerrara, Jen_HK
dc.contributor.authorDeVito, Men_HK
dc.contributor.authorGranger, Ten_HK
dc.contributor.authorPigott, Jen_HK
dc.contributor.authorChang, J-Ken_HK
dc.contributor.authorHyman, Aen_HK
dc.date.accessioned2010-09-17T10:08:07Z-
dc.date.available2010-09-17T10:08:07Z-
dc.date.issued1994en_HK
dc.identifier.citationLife Sciences, 1994, v. 54 n. 23, p. PL409-PL412en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90770-
dc.description.abstractThe purpose of the present study was to investigate the effects of products of the ADM gene other than ADM on systemic hemodynamics in the anesthetized rat, rabbit, piglet, cat and dog. Bolus intravenous (i.v.) injections of rat proADM22-41 (3-30μg) significantly decreased systemic arterial pressure (SAP) and systemic vascular resistance in the anesthetized rat. Unlike ADM, rat proADM22-41 markedly increased cardiac output in the rat. Bolus i.v. injections of human proADM22-41 up to 500μg had not effect in all species studied and rat proADM22-41 had no effect in species other than the rat. The present data suggest that rat proADM22- 41 is a novel product of the ADM gene other than ADM and possesses marked systemic vasodilator activity. The present data also suggest that the hemodynamic activity of this peptide is species specific.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.subjectSpecies Index: Animaliaen_HK
dc.subjectCanis Familiarisen_HK
dc.subjectFelis Catusen_HK
dc.subjectOryctolagus Cuniculusen_HK
dc.subjectSus Scrofaen_HK
dc.titleProdepin: A new product of the adrenomedullin (ADM) gene has systemic vasodilator activityen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, B:blin@hku.hken_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0024-3205(94)90124-4en_HK
dc.identifier.pmid8196484-
dc.identifier.scopuseid_2-s2.0-23444452285en_HK
dc.identifier.volume54en_HK
dc.identifier.issue23en_HK
dc.identifier.spagePL409en_HK
dc.identifier.epagePL412en_HK
dc.identifier.isiWOS:A1994NJ35000012-
dc.identifier.issnl0024-3205-

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