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Article: Assembly of checkpoint and repair machineries at DNA damage sites

TitleAssembly of checkpoint and repair machineries at DNA damage sites
Authors
Huen, MSYChen, J
KeywordsChemicals And Cas Registry Numbers
Issue Date2010
PublisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tibs
Citation
Trends In Biochemical Sciences, 2010, v. 35 n. 2, p. 101-108 How to Cite?
DOI: http://dx.doi.org/10.1016/j.tibs.2009.09.001
AbstractThe remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/90830
ISSN
0968-0004
2023 Impact Factor: 11.6
2023 SCImago Journal Rankings: 4.074
PubMed Central ID
PMC3209802
ISI Accession Number ID
WOS:000274714300005
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHuen, MSYen_HK
dc.contributor.authorChen, Jen_HK
dc.date.accessioned2010-09-17T10:09:01Z-
dc.date.available2010-09-17T10:09:01Z-
dc.date.issued2010en_HK
dc.identifier.citationTrends In Biochemical Sciences, 2010, v. 35 n. 2, p. 101-108en_HK
dc.identifier.issn0968-0004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/90830-
dc.description.abstractThe remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tibsen_HK
dc.relation.ispartofTrends in Biochemical Sciencesen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleAssembly of checkpoint and repair machineries at DNA damage sitesen_HK
dc.typeArticleen_HK
dc.identifier.emailHuen, MSY:huen.michael@hku.hken_HK
dc.identifier.authorityHuen, MSY=rp01336en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.tibs.2009.09.001en_HK
dc.identifier.pmid19875294-
dc.identifier.pmcidPMC3209802-
dc.identifier.scopuseid_2-s2.0-75949124023en_HK
dc.identifier.hkuros169510-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75949124023&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue2en_HK
dc.identifier.spage101en_HK
dc.identifier.epage108en_HK
dc.identifier.isiWOS:000274714300005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHuen, MSY=23004751500en_HK
dc.identifier.scopusauthoridChen, J=35261693300en_HK
dc.identifier.citeulike6199221-
dc.identifier.issnl0968-0004-

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