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- Publisher Website: 10.1016/S0024-3205(99)00627-X
- Scopus: eid_2-s2.0-0002418273
- PMID: 10794074
- WOS: WOS:000084726800012
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Article: Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension
Title | Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension |
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Authors | |
Keywords | Species Index: Animalia |
Issue Date | 1999 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie |
Citation | Life Sciences, 1999, v. 66 n. 6, p. PL99-PL104 How to Cite? |
Abstract | The purpose of the present study was to investigate the effects of L- N5-(1-iminoethyl)-ornithine hydrochloride (L-NIO), an inhibitor of nitric oxide (NO) formation, and [Phe1-Ψ(CH2-NH)-Gly2]Nociceptin(1-13)-NH2 (Phe-NOC), a nociceptin receptor antagonist, on the systemic vasodepressor response to nociceptin in the anesthetized rat. The systemic vasodepressor response to bolus intravenous (i.v.) injections of nociceptin was significantly reduced by L-NIO and Phe-NOC. The present data suggest activation of nociceptin receptors dilates the systemic vascular bed through a NO-dependent pathway. These data also demonstrate Phe-NOC is an efficacious and selective nociceptin receptor antagonist in vivo. |
Persistent Identifier | http://hdl.handle.net/10722/90944 |
ISSN | 2023 Impact Factor: 5.2 2023 SCImago Journal Rankings: 1.257 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Lin, B | en_HK |
dc.contributor.author | Waterman, R | en_HK |
dc.contributor.author | Lippton, H | en_HK |
dc.date.accessioned | 2010-09-17T10:10:43Z | - |
dc.date.available | 2010-09-17T10:10:43Z | - |
dc.date.issued | 1999 | en_HK |
dc.identifier.citation | Life Sciences, 1999, v. 66 n. 6, p. PL99-PL104 | en_HK |
dc.identifier.issn | 0024-3205 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/90944 | - |
dc.description.abstract | The purpose of the present study was to investigate the effects of L- N5-(1-iminoethyl)-ornithine hydrochloride (L-NIO), an inhibitor of nitric oxide (NO) formation, and [Phe1-Ψ(CH2-NH)-Gly2]Nociceptin(1-13)-NH2 (Phe-NOC), a nociceptin receptor antagonist, on the systemic vasodepressor response to nociceptin in the anesthetized rat. The systemic vasodepressor response to bolus intravenous (i.v.) injections of nociceptin was significantly reduced by L-NIO and Phe-NOC. The present data suggest activation of nociceptin receptors dilates the systemic vascular bed through a NO-dependent pathway. These data also demonstrate Phe-NOC is an efficacious and selective nociceptin receptor antagonist in vivo. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie | en_HK |
dc.relation.ispartof | Life Sciences | en_HK |
dc.subject | Species Index: Animalia | en_HK |
dc.title | Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lin, B:blin@hku.hk | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0024-3205(99)00627-X | en_HK |
dc.identifier.pmid | 10794074 | - |
dc.identifier.scopus | eid_2-s2.0-0002418273 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0002418273&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 66 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | PL99 | en_HK |
dc.identifier.epage | PL104 | en_HK |
dc.identifier.isi | WOS:000084726800012 | - |
dc.identifier.issnl | 0024-3205 | - |