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- Scopus: eid_2-s2.0-0028294044
- PMID: 8064169
- WOS: WOS:A1994NK15500015
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Article: Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension
Title | Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension |
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Authors | |
Keywords | Chemicals And Cas Registry Numbers |
Issue Date | 1994 |
Publisher | Lippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/ |
Citation | Journal Of Hypertension, 1994, v. 12 n. 4, p. 449-454 How to Cite? |
Abstract | Objectives: To study the relationship between hypertension and the plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to determine whether the plasma levels of BNP and CNP are correlated. Design: A cross-sectional study of the plasma levels of BNP and CNP in hypertensive patients and normotensive controls matched for age and sex was performed. Setting: The hypertension research clinic in a teaching hospital and well-person risk factor screening clinics in general practice health centres. Participants: Fifty-four subjects (29 hypertensive, 25 normotensive controls) took part in the study after giving their informed consent. Hypertensive patients (n = 19) were paired with normotensive controls (n = 19) matched for age and sex to form a subgroup before analysis of the plasma. Methods: The plasma levels of BNP and CNP were determined by specific radioimmunoassays. Results: The mean plasma concentration of BNP was significantly higher in the hypertensive group than in the paired controls. In contrast, the mean plasma concentration of CNP was not significantly different in the hypertensive group than in the paired controls. Multiple regression analysis of all 54 subjects showed that the plasma level of BNP correlated significantly with age and systolic blood pressure, whereas the plasma level of CNP correlated significantly with sex, heart rate and alcohol intake. The CNP levels did not correlate significantly with either systolic or diastolic blood pressure, or with plasma brain natriuretic levels. Conclusions: Hypertension is associated with raised BNP but not CNP plasma levels. |
Persistent Identifier | http://hdl.handle.net/10722/91494 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.134 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheung, BM | en_HK |
dc.contributor.author | Brown, MJ | en_HK |
dc.date.accessioned | 2010-09-17T10:20:19Z | - |
dc.date.available | 2010-09-17T10:20:19Z | - |
dc.date.issued | 1994 | en_HK |
dc.identifier.citation | Journal Of Hypertension, 1994, v. 12 n. 4, p. 449-454 | en_HK |
dc.identifier.issn | 0263-6352 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/91494 | - |
dc.description.abstract | Objectives: To study the relationship between hypertension and the plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to determine whether the plasma levels of BNP and CNP are correlated. Design: A cross-sectional study of the plasma levels of BNP and CNP in hypertensive patients and normotensive controls matched for age and sex was performed. Setting: The hypertension research clinic in a teaching hospital and well-person risk factor screening clinics in general practice health centres. Participants: Fifty-four subjects (29 hypertensive, 25 normotensive controls) took part in the study after giving their informed consent. Hypertensive patients (n = 19) were paired with normotensive controls (n = 19) matched for age and sex to form a subgroup before analysis of the plasma. Methods: The plasma levels of BNP and CNP were determined by specific radioimmunoassays. Results: The mean plasma concentration of BNP was significantly higher in the hypertensive group than in the paired controls. In contrast, the mean plasma concentration of CNP was not significantly different in the hypertensive group than in the paired controls. Multiple regression analysis of all 54 subjects showed that the plasma level of BNP correlated significantly with age and systolic blood pressure, whereas the plasma level of CNP correlated significantly with sex, heart rate and alcohol intake. The CNP levels did not correlate significantly with either systolic or diastolic blood pressure, or with plasma brain natriuretic levels. Conclusions: Hypertension is associated with raised BNP but not CNP plasma levels. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Lippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/ | en_HK |
dc.relation.ispartof | Journal of Hypertension | en_HK |
dc.subject | Chemicals And Cas Registry Numbers | en_HK |
dc.subject.mesh | Aging - physiology | en_HK |
dc.subject.mesh | Blood Pressure | en_HK |
dc.subject.mesh | Cross-Sectional Studies | en_HK |
dc.subject.mesh | Epinephrine - blood | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Hypertension - blood - physiopathology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Natriuretic Peptide, Brain | en_HK |
dc.subject.mesh | Natriuretic Peptide, C-Type | en_HK |
dc.subject.mesh | Nerve Tissue Proteins - blood | en_HK |
dc.subject.mesh | Norepinephrine - blood | en_HK |
dc.subject.mesh | Proteins - metabolism | en_HK |
dc.subject.mesh | Radioimmunoassay | en_HK |
dc.subject.mesh | Reference Values | en_HK |
dc.subject.mesh | Sex Characteristics | en_HK |
dc.title | Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cheung, BMY:mycheung@hku.hk | en_HK |
dc.identifier.authority | Cheung, BMY=rp1321 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 8064169 | - |
dc.identifier.scopus | eid_2-s2.0-0028294044 | en_HK |
dc.identifier.volume | 12 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 449 | en_HK |
dc.identifier.epage | 454 | en_HK |
dc.identifier.isi | WOS:A1994NK15500015 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.issnl | 0263-6352 | - |