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Article: Adult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases
Title | Adult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases | ||||||
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Authors | |||||||
Keywords | Chemicals And Cas Registry Numbers | ||||||
Issue Date | 2009 | ||||||
Publisher | Springer Japan KK | ||||||
Citation | International Journal of Hematology, 2009, v. 89 n. 4, p. 431-437 How to Cite? | ||||||
Abstract | Acute lymphoblastic leukemia (ALL) accounts for 20-30% of adult leukemia in the West. However, detailed studies of B-cell-specific ALL in adult Asian populations are lacking. We diagnosed and characterized 137 consecutive cases of precursor B lymphoblastic leukemia (precursor B-cell ALL) presented to our laboratory in Shanghai using the WHO 2001 classification system. Patient clinical, phenotypic and cytogenetic characteristics were correlated with outcome. In contrast to Western studies, females (71) outnumbered males (66) partly due to an increased prevalence of the CD10- pro B-cell phenotype. Females with a CD10- pro B-cell phenotype exhibited significantly better overall survival than males. The most common cytogenetic abnormality was the Philadelphia chromosome (PH/BCR/ABL) which was found in approximately 37% of the cases. Cases of precursor B cell ALL lacking the PH/BCR/ABL genotype exhibited a pronounced age-dependent, gender prevalence with a modal age in the sixth decade for females compared to the second decade for males. These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance. © 2009 The Japanese Society of Hematology. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/92262 | ||||||
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.594 | ||||||
ISI Accession Number ID |
Funding Information: We would like to extend our appreciation to Ann Louden for manuscript and clerical assistance and Anh Le, Qian Chen and Allan Holsomback for database management. We would also like to thank the participating hospitals including Huashan Hospital, Xinhua Hospital, Long March Hospital, Huang Pu Central District Hospital, Renji Hospital, Ruijin Hospital, Huadong Hospital, Jin An Central Hospital, No. 1 People's Hospital, No. 5 People's Hospital, No. 6 People's Hospital, No. 9 People's Hospital, Yang Pu Central Hospital, Zha Bei Central Hospital, Shu Guang Hospital, Chang Ning Central Hospital, Tong Ji Hospital, Shong Jin Central Hospital, Zhong Shan Hospital, Railway Hospital, Rong Hua Hospital, Changhai Hospital, Occupational Disease Hospital, Jiading Central Hospital, 455 Hospital, Shidong Hospital, No. 1 Baoshan Hospital, and Putuo Central Hospital. This work was conducted as part of the Shanghai Health Study and was funded by the Benzene Research Health Consortium consisting of British Petroleum, Amoco, Chevron Texaco, ExxonMobil, Conoco Philips and Shell Chemical Companies. | ||||||
References |
DC Field | Value | Language |
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dc.contributor.author | Bao, L | en_HK |
dc.contributor.author | Gross, SA | en_HK |
dc.contributor.author | Ryder, J | en_HK |
dc.contributor.author | Wang, X | en_HK |
dc.contributor.author | Ji, M | en_HK |
dc.contributor.author | Chen, Y | en_HK |
dc.contributor.author | Yang, Y | en_HK |
dc.contributor.author | Zhu, S | en_HK |
dc.contributor.author | Irons, RD | en_HK |
dc.date.accessioned | 2010-09-17T10:40:51Z | - |
dc.date.available | 2010-09-17T10:40:51Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | International Journal of Hematology, 2009, v. 89 n. 4, p. 431-437 | en_HK |
dc.identifier.issn | 0925-5710 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/92262 | - |
dc.description.abstract | Acute lymphoblastic leukemia (ALL) accounts for 20-30% of adult leukemia in the West. However, detailed studies of B-cell-specific ALL in adult Asian populations are lacking. We diagnosed and characterized 137 consecutive cases of precursor B lymphoblastic leukemia (precursor B-cell ALL) presented to our laboratory in Shanghai using the WHO 2001 classification system. Patient clinical, phenotypic and cytogenetic characteristics were correlated with outcome. In contrast to Western studies, females (71) outnumbered males (66) partly due to an increased prevalence of the CD10- pro B-cell phenotype. Females with a CD10- pro B-cell phenotype exhibited significantly better overall survival than males. The most common cytogenetic abnormality was the Philadelphia chromosome (PH/BCR/ABL) which was found in approximately 37% of the cases. Cases of precursor B cell ALL lacking the PH/BCR/ABL genotype exhibited a pronounced age-dependent, gender prevalence with a modal age in the sixth decade for females compared to the second decade for males. These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance. © 2009 The Japanese Society of Hematology. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Springer Japan KK | en_HK |
dc.relation.ispartof | International Journal of Hematology | en_HK |
dc.subject | Chemicals And Cas Registry Numbers | en_HK |
dc.title | Adult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chen, Y:ychenc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chen, Y=rp1318 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s12185-009-0283-8 | en_HK |
dc.identifier.scopus | eid_2-s2.0-67449136035 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67449136035&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 89 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 431 | en_HK |
dc.identifier.epage | 437 | en_HK |
dc.identifier.isi | WOS:000265574500004 | - |
dc.identifier.citeulike | 4264150 | - |
dc.identifier.issnl | 0925-5710 | - |