File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1177/1545968305284198
- WOS: WOS:000235280000006
- Find via
Supplementary
-
Citations:
- Web of Science: 0
- Appears in Collections:
Conference Paper: Neuroregeneration in the central nervous system
Title | Neuroregeneration in the central nervous system |
---|---|
Authors | |
Issue Date | 2006 |
Publisher | Sage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=336 |
Citation | The 4th World Congress for NeuroRehabilitation, Hong Kong, 12-16 February 2006. In Neurorehabilitation and Neural Repair, 2006, v. 20 n. 1, p. 77 Abstract no. S6C-1 How to Cite? |
Abstract | Axons in the central nervous system (CNS) in adult mammals
do not generally regenerate after damage. It is hypothesized
that the lack of axonal regeneration is because of both extrinsic
and intrinsic factors. The extrinsic factors would include
the insufficient supply of trophic factor and/or neurite growth
permissive molecules and the presence of inhibitory molecules
in the axons. The intrinsic factor could be the decrease in the
axonal growth potential in adult mammals. We have used a series
of approaches to alter the extrinsic environment and to enhance
the growth potentials of adult axons in the optic nerve
and spinal cord. The external environment of the CNS axons
could be enhanced by providing an environment suitable for
axon regeneration, e.g., through the provision of a conduit using
peripheral nerve graft for the damaged axons or Schwann
cells or olfactory-ensheathing cell transplantation. We could
also neutralize the inhibitory molecules using IN-1 or Nogo receptor
blocker or to block inhibitory signaling pathways via
Rho pathway inhibitor. The prevention of scar tissue formation
by Chondroitinase ABC could also promote axon regeneration
in CNS. The intrinsic factors could be modified to enhance regeneration
by supplementing appropriate neurotrophic factors,
e.g., ciliary neurotrophic factors (CNTF), or by elevating intrinsic
regrowth capability, e.g., via the use of cAMP. Our studies
suggest that a combined experimental approach is critical in optimizing
the regeneration ability of CNS axons in adult
mammals. |
Persistent Identifier | http://hdl.handle.net/10722/95311 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.456 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | So, KF | en_HK |
dc.date.accessioned | 2010-09-25T15:58:13Z | - |
dc.date.available | 2010-09-25T15:58:13Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | The 4th World Congress for NeuroRehabilitation, Hong Kong, 12-16 February 2006. In Neurorehabilitation and Neural Repair, 2006, v. 20 n. 1, p. 77 Abstract no. S6C-1 | en_HK |
dc.identifier.issn | 1545-9683 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/95311 | - |
dc.description.abstract | Axons in the central nervous system (CNS) in adult mammals do not generally regenerate after damage. It is hypothesized that the lack of axonal regeneration is because of both extrinsic and intrinsic factors. The extrinsic factors would include the insufficient supply of trophic factor and/or neurite growth permissive molecules and the presence of inhibitory molecules in the axons. The intrinsic factor could be the decrease in the axonal growth potential in adult mammals. We have used a series of approaches to alter the extrinsic environment and to enhance the growth potentials of adult axons in the optic nerve and spinal cord. The external environment of the CNS axons could be enhanced by providing an environment suitable for axon regeneration, e.g., through the provision of a conduit using peripheral nerve graft for the damaged axons or Schwann cells or olfactory-ensheathing cell transplantation. We could also neutralize the inhibitory molecules using IN-1 or Nogo receptor blocker or to block inhibitory signaling pathways via Rho pathway inhibitor. The prevention of scar tissue formation by Chondroitinase ABC could also promote axon regeneration in CNS. The intrinsic factors could be modified to enhance regeneration by supplementing appropriate neurotrophic factors, e.g., ciliary neurotrophic factors (CNTF), or by elevating intrinsic regrowth capability, e.g., via the use of cAMP. Our studies suggest that a combined experimental approach is critical in optimizing the regeneration ability of CNS axons in adult mammals. | - |
dc.language | eng | en_HK |
dc.publisher | Sage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=336 | en_HK |
dc.relation.ispartof | Neurorehabilitation and Neural Repair | en_HK |
dc.title | Neuroregeneration in the central nervous system | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1545-9683&volume=20&issue=1&spage=77 No. S6C&epage=1&date=2006&atitle=Neuroregeneration+in+the+central+nervous+system | en_HK |
dc.identifier.email | So, KF: hrmaskf@hkucc.hku.hk | en_HK |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1177/1545968305284198 | - |
dc.identifier.hkuros | 115436 | en_HK |
dc.identifier.volume | 20 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 77 | en_HK |
dc.identifier.epage | 77 | en_HK |
dc.identifier.isi | WOS:000235280000006 | - |
dc.identifier.issnl | 1545-9683 | - |