Neurodegeneration: the processes

Abstract

While neuronal apoptosis has long been considered to be the major mode of neurodegeneration in chronic neurological disorders in Parkinson’s disease, increasing lines of findings have demonstrated that neurodegeneration are mingle of autophagy, synaptic retraction, and axonal transport. Different survival and pro-apoptotic signalling pathways become biological targets for intervention. Apart from investigating the degenerative signalling in neurons, the responses of glial cells are important to determine the fate of dopaminergic neurons. Therefore, pharmacological interventions of neurodegenerative processes in Parkinson’s disease can be on both glial cells and neurons. I will at first briefly introduce different modes …