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Conference Paper: Tax-induced recruitment of TORC family coactivators is required for transcriptional activation of HTLV-I LTR
Title | Tax-induced recruitment of TORC family coactivators is required for transcriptional activation of HTLV-I LTR |
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Authors | |
Issue Date | 2007 |
Publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aid |
Citation | The 13th International Conference on Human Retrovirology
HTLV and Related Viruses, Hakone, Japan, 21-25 May 2007. In AIDS Research and Human Retroviruses, 2007, v. 23 n. 4, p. 646 How to Cite? |
Abstract | HTLV-I Tax is pivotally involved in leukemogenesis, and it
potently transactivates viral transcription from the LTR. Mechanisms
through which Tax activates LTR have been established,
but coactivators of this process remain to be identified and characterized.
We have recently shown that all three members of
the newly identified TORC family of transcriptional regulators
are coactivators of Tax for LTR-driven expression. TORC coactivation
requires CREB, but not ATF4 or other bZIP factors.
Tax physically interacts with TORC1, TORC2, and TORC3,
relocating them to specific intranuclear subdomains. a chromatin
immunoprecipitation assay indicates an association of
TORC1, TORC2, and TORC3 with the 21-bp repeats of the
HTLV-1 LTR. Depletion of TORC coactivators was accomplished
using RNAi-inhibited Tax-dependent transcriptional activation
of HTLV-1 LTR. Thus, TORC members are essential
Tax coactivators for viral transcription. |
Persistent Identifier | http://hdl.handle.net/10722/95970 |
ISSN | 2023 Impact Factor: 1.5 2023 SCImago Journal Rankings: 0.542 |
DC Field | Value | Language |
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dc.contributor.author | Siu, YT | en_HK |
dc.contributor.author | Jin, D | en_HK |
dc.date.accessioned | 2010-09-25T16:19:16Z | - |
dc.date.available | 2010-09-25T16:19:16Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | The 13th International Conference on Human Retrovirology HTLV and Related Viruses, Hakone, Japan, 21-25 May 2007. In AIDS Research and Human Retroviruses, 2007, v. 23 n. 4, p. 646 | en_HK |
dc.identifier.issn | 0889-2229 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/95970 | - |
dc.description.abstract | HTLV-I Tax is pivotally involved in leukemogenesis, and it potently transactivates viral transcription from the LTR. Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. We have recently shown that all three members of the newly identified TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3, relocating them to specific intranuclear subdomains. a chromatin immunoprecipitation assay indicates an association of TORC1, TORC2, and TORC3 with the 21-bp repeats of the HTLV-1 LTR. Depletion of TORC coactivators was accomplished using RNAi-inhibited Tax-dependent transcriptional activation of HTLV-1 LTR. Thus, TORC members are essential Tax coactivators for viral transcription. | - |
dc.language | eng | en_HK |
dc.publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aid | en_HK |
dc.relation.ispartof | AIDS Research and Human Retroviruses | en_HK |
dc.title | Tax-induced recruitment of TORC family coactivators is required for transcriptional activation of HTLV-I LTR | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-2229&volume=23&spage=646&epage=&date=2007&atitle=Tax-induced+recruitment+of+TORC+family+coactivators+is+required+for+transcriptional+activation+of+HTLV-I+LTR | en_HK |
dc.identifier.email | Siu, YT: ytsiu@hkucc.hku.hk | en_HK |
dc.identifier.email | Jin, D: dyjin@hkucc.hku.hk | en_HK |
dc.identifier.authority | Jin, D=rp00452 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1089/aid.2007.9997 | - |
dc.identifier.hkuros | 127317 | en_HK |
dc.identifier.hkuros | 127313 | - |
dc.identifier.volume | 23 | en_HK |
dc.identifier.spage | 646 | en_HK |
dc.identifier.issnl | 0889-2229 | - |