Dr. Kwong-Man Ng obtained his Ph.D degree in the Department of Zoology (now as part of the school of biological science), The University of Hong Kong in 2006. He has been working as visiting scholar in the University of Western Ontario and the University of British Columbia and received post-doctoral training on Human Stem Cell biology in the University of California, Davis, and the Departments of Physiology and Medicine, the University of Hong Kong. Currently, he is working as a Research Assistant Professor at the cardiology division, the Department of Medicine, The University of Hong Kong. His research focuses on the biotechnological and clinical applications of human pluripotent stem cells in the studies of inherited cardiac disorders. Owing to the lack of human cardiomyocyte-based cellular models, the study of the pathogenic mechanism associated with particular gene mutation have been a challenging task. To date, with the advancement in the induced pluripotent stem cells (iPSCs) technology, terminally differentiated somatic cells from patients carrying specific cardiomyopathy-associated mutations can be reprogrammed into iPSCs and subsequently differentiated into functional cardiomyocytes. This offers a new approach for modeling human inherited cardiac disorders (Figure 1). In recent years, Dr. Ng and colleagues in the cardiology division has generated various iPSCs lines from the patients suffered from different types of cardiomyopathies, these studies not only provided new insights on the pathogenic mechanisms underlining the mutations of DES and LMNA, but also offered a new human-cardiomyocytes based platform for drug testing.
|Term Period||Position||Professional Societies|
|05/2016||Editorial board member, Cardiology section||Scientific Reports|
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