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- Publisher Website: 10.1007/s10856-009-3691-7
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- PMID: 19184371
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Article: Bioactive borosilicate glass scaffolds: In vitro degradation and bioactivity behaviors
Title | Bioactive borosilicate glass scaffolds: In vitro degradation and bioactivity behaviors | ||||||
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Authors | |||||||
Issue Date | 2009 | ||||||
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530 | ||||||
Citation | Journal Of Materials Science: Materials In Medicine, 2009, v. 20 n. 6, p. 1237-1243 How to Cite? | ||||||
Abstract | Bioactive borosilicate glass scaffolds with the pores of several hundred micrometers and a competent compressive strength were prepared through replication method. The in vitro degradation and bioactivity behaviors of the scaffolds have been investigated by immersing the scaffolds statically in diluted phosphate solution at 37°C, up to 360 h. To monitor the degradation progress of the scaffolds, the amount of leaching elements from the scaffolds were determined by ICP-AES. The XRD and SEM results reveal that, during the degradation of scaffolds, the borosilicate scaffolds converted to hydroxyapatite. The compressive strength of the scaffolds decreased during degradation, in the way that can be well predicted by the degradation products, or the leachates, from the scaffolds. MTT assay results demonstrate that the degradation products have little, if any, inhibition effect on the cell proliferation, when diluted to a certain concentration ([B] <2.690 and pH value at neutral level). The study shows that borosilicate glass scaffold could be a promising candidate for bone tissue engineering material. © 2009 Springer Science+Business Media, LLC. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/125172 | ||||||
ISSN | 2021 Impact Factor: 4.727 2020 SCImago Journal Rankings: 0.644 | ||||||
ISI Accession Number ID |
Funding Information: This work was supported by the Science and Technology Commission of Shanghai Municipality, China, under Project (Grant No. 05DJ14006) (Grant No. 08441900500) and Hong Kong RGC: 71437/07E. | ||||||
References |
DC Field | Value | Language |
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dc.contributor.author | Liu, X | en_HK |
dc.contributor.author | Huang, W | en_HK |
dc.contributor.author | Fu, H | en_HK |
dc.contributor.author | Yao, A | en_HK |
dc.contributor.author | Wang, D | en_HK |
dc.contributor.author | Pan, H | en_HK |
dc.contributor.author | Lu, WW | en_HK |
dc.contributor.author | Jiang, X | en_HK |
dc.contributor.author | Zhang, X | en_HK |
dc.date.accessioned | 2010-10-31T11:15:32Z | - |
dc.date.available | 2010-10-31T11:15:32Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Journal Of Materials Science: Materials In Medicine, 2009, v. 20 n. 6, p. 1237-1243 | en_HK |
dc.identifier.issn | 0957-4530 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/125172 | - |
dc.description.abstract | Bioactive borosilicate glass scaffolds with the pores of several hundred micrometers and a competent compressive strength were prepared through replication method. The in vitro degradation and bioactivity behaviors of the scaffolds have been investigated by immersing the scaffolds statically in diluted phosphate solution at 37°C, up to 360 h. To monitor the degradation progress of the scaffolds, the amount of leaching elements from the scaffolds were determined by ICP-AES. The XRD and SEM results reveal that, during the degradation of scaffolds, the borosilicate scaffolds converted to hydroxyapatite. The compressive strength of the scaffolds decreased during degradation, in the way that can be well predicted by the degradation products, or the leachates, from the scaffolds. MTT assay results demonstrate that the degradation products have little, if any, inhibition effect on the cell proliferation, when diluted to a certain concentration ([B] <2.690 and pH value at neutral level). The study shows that borosilicate glass scaffold could be a promising candidate for bone tissue engineering material. © 2009 Springer Science+Business Media, LLC. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530 | en_HK |
dc.relation.ispartof | Journal of Materials Science: Materials in Medicine | en_HK |
dc.rights | The original publication is available at www.springerlink.com | - |
dc.subject.mesh | Biocompatible Materials - chemistry | - |
dc.subject.mesh | Bone Substitutes - chemistry | - |
dc.subject.mesh | Glass - chemistry | - |
dc.subject.mesh | Silicates - chemistry | - |
dc.subject.mesh | Tissue Scaffolds | - |
dc.title | Bioactive borosilicate glass scaffolds: In vitro degradation and bioactivity behaviors | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0957-4530&volume=20&issue=6&spage=1237&epage=1243&date=2009&atitle=Bioactive+borosilicate+glass+scaffolds:+in+vitro+degradation+and+bioactivity+behaviors | - |
dc.identifier.email | Pan, H:haobo@hku.hk | en_HK |
dc.identifier.email | Lu, WW:wwlu@hku.hk | en_HK |
dc.identifier.authority | Pan, H=rp01564 | en_HK |
dc.identifier.authority | Lu, WW=rp00411 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s10856-009-3691-7 | en_HK |
dc.identifier.pmid | 19184371 | - |
dc.identifier.scopus | eid_2-s2.0-67349193784 | en_HK |
dc.identifier.hkuros | 181272 | en_HK |
dc.identifier.hkuros | 163515 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67349193784&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 20 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 1237 | en_HK |
dc.identifier.epage | 1243 | en_HK |
dc.identifier.isi | WOS:000265881200005 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Liu, X=25639972700 | en_HK |
dc.identifier.scopusauthorid | Huang, W=7407905904 | en_HK |
dc.identifier.scopusauthorid | Fu, H=15759505300 | en_HK |
dc.identifier.scopusauthorid | Yao, A=15761582600 | en_HK |
dc.identifier.scopusauthorid | Wang, D=8334565700 | en_HK |
dc.identifier.scopusauthorid | Pan, H=7403295092 | en_HK |
dc.identifier.scopusauthorid | Lu, WW=7404215221 | en_HK |
dc.identifier.scopusauthorid | Jiang, X=7404627219 | en_HK |
dc.identifier.scopusauthorid | Zhang, X=22939791100 | en_HK |
dc.identifier.citeulike | 3994688 | - |
dc.identifier.issnl | 0957-4530 | - |