File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women

TitleTNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women
Authors
KeywordsAge at menarche
Age at natural menopause
Association
Haplotypes
Polymorphisms
TNFRSF11A
TNFSF11
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com
Citation
Menopause, 2010, v. 17 n. 5, p. 1048-1054 How to Cite?
AbstractObjective: Menarche and menopause mark the lower and upper limits of the female reproductive period. The timing of these events influences women's health in later life. The onsets of menarche and menopause have a strong genetic basis. We tested two genes, TNFRSF11A (RANK) and TNFSF11 (RANKL), for their association with age at menarche (AM) and age at natural menopause (ANM). Methods: Nineteen single nucleotide polymorphisms (SNPs) of TNFRSF11A and 12 SNPs of TNFSF11 were genotyped in a random sample of 306 unrelated white women. This sample was analyzed for the association of the SNPs and common haplotypes with AM. Then, a subsample of 211 women with natural menopause was analyzed for the association of both genes with ANM. Smoking, alcohol intake, and duration of lactation were applied as covariates in the association analyses. Results: Three polymorphisms of TNFSF11 were associated with AM: rs2200287 (P = 0.005), rs9525641 (P = 0.039), and rs1054016 (P = 0.047). Two SNPs of this gene, rs346578 and rs9525641, showed an association with ANM (P = 0.007 and P = 0.011, respectively). Two SNPs of TNFRSF11A were associated with AM (rs3826620; P = 0.022) and ANM (rs8086340; P = 0.015). Multiple SNP-SNP and SNP-environment interaction effects on AM and ANM were detected for both genes. One polymorphism of TNFRSF11A, rs4436867, was not directly associated with either trait but indicated significant interactions with four TNFSF11 polymorphisms on ANM. Two other TNFRSF11A polymorphisms, rs4941125 and rs7235803, showed interaction effects with several TNFSF11 polymorphisms on AM. Both genes manifested significant interaction with the duration of breast-feeding in their effect on ANM. Conclusions: The TNFRSF11A and TNFSF11 genes are associated with the onset of AM and ANM in white women. © 2010 by The North American Menopause Society.
Persistent Identifierhttp://hdl.handle.net/10722/127430
ISSN
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.984
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthR01 AR050496
K01 AR02170-01
R01 AR45349-01
R01 GM60402-01A1
State of NebraskaLB595
National Science Foundation of China
Huo Ying Dong Education Foundation, HuNan Province
Xi'an Jiaotong University
Ministry of Education of China
Funding Information:

The authors were supported by grants from the National Institutes of Health (R01 AR050496, K01 AR02170-01, R01 AR45349-01, and R01 GM60402-01A1) and the State of Nebraska (grant LB595). The authors also thank the National Science Foundation of China, Huo Ying Dong Education Foundation, HuNan Province, Xi'an Jiaotong University, and the Ministry of Education of China for their financial support.

References

 

DC FieldValueLanguage
dc.contributor.authorLu, Yen_HK
dc.contributor.authorLiu, Pen_HK
dc.contributor.authorRecker, RRen_HK
dc.contributor.authorDeng, HWen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.date.accessioned2010-10-31T13:25:10Z-
dc.date.available2010-10-31T13:25:10Z-
dc.date.issued2010en_HK
dc.identifier.citationMenopause, 2010, v. 17 n. 5, p. 1048-1054en_HK
dc.identifier.issn1072-3714en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127430-
dc.description.abstractObjective: Menarche and menopause mark the lower and upper limits of the female reproductive period. The timing of these events influences women's health in later life. The onsets of menarche and menopause have a strong genetic basis. We tested two genes, TNFRSF11A (RANK) and TNFSF11 (RANKL), for their association with age at menarche (AM) and age at natural menopause (ANM). Methods: Nineteen single nucleotide polymorphisms (SNPs) of TNFRSF11A and 12 SNPs of TNFSF11 were genotyped in a random sample of 306 unrelated white women. This sample was analyzed for the association of the SNPs and common haplotypes with AM. Then, a subsample of 211 women with natural menopause was analyzed for the association of both genes with ANM. Smoking, alcohol intake, and duration of lactation were applied as covariates in the association analyses. Results: Three polymorphisms of TNFSF11 were associated with AM: rs2200287 (P = 0.005), rs9525641 (P = 0.039), and rs1054016 (P = 0.047). Two SNPs of this gene, rs346578 and rs9525641, showed an association with ANM (P = 0.007 and P = 0.011, respectively). Two SNPs of TNFRSF11A were associated with AM (rs3826620; P = 0.022) and ANM (rs8086340; P = 0.015). Multiple SNP-SNP and SNP-environment interaction effects on AM and ANM were detected for both genes. One polymorphism of TNFRSF11A, rs4436867, was not directly associated with either trait but indicated significant interactions with four TNFSF11 polymorphisms on ANM. Two other TNFRSF11A polymorphisms, rs4941125 and rs7235803, showed interaction effects with several TNFSF11 polymorphisms on AM. Both genes manifested significant interaction with the duration of breast-feeding in their effect on ANM. Conclusions: The TNFRSF11A and TNFSF11 genes are associated with the onset of AM and ANM in white women. © 2010 by The North American Menopause Society.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.comen_HK
dc.relation.ispartofMenopauseen_HK
dc.rightsThis is a non-final version of an article published in final form in (provide complete journal citation)-
dc.subjectAge at menarcheen_HK
dc.subjectAge at natural menopauseen_HK
dc.subjectAssociationen_HK
dc.subjectHaplotypesen_HK
dc.subjectPolymorphismsen_HK
dc.subjectTNFRSF11Aen_HK
dc.subjectTNFSF11en_HK
dc.subject.meshHaplotypes - genetics-
dc.subject.meshMenarche - genetics-
dc.subject.meshMenopause - genetics-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshRANK Ligand - genetics-
dc.titleTNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1072-3714&volume=17&issue=5&spage=1048&epage=1054&date=2010&atitle=TNFRSF11A+and+TNFSF11+are+associated+with+age+at+menarche+and+natural+menopause+in+white+womenen_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/gme.0b013e3181d5d523en_HK
dc.identifier.pmid20531232-
dc.identifier.pmcidPMC2939156-
dc.identifier.scopuseid_2-s2.0-77957693632en_HK
dc.identifier.hkuros180172en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957693632&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1048en_HK
dc.identifier.epage1054en_HK
dc.identifier.eissn1530-0374-
dc.identifier.isiWOS:000281614700027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLu, Y=26643076900en_HK
dc.identifier.scopusauthoridLiu, P=7404618030en_HK
dc.identifier.scopusauthoridRecker, RR=7007086875en_HK
dc.identifier.scopusauthoridDeng, HW=7401775190en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK
dc.identifier.issnl1072-3714-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats