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- Publisher Website: 10.1007/s00109-008-0350-2
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- PMID: 18458800
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Article: DC-SIGN and L-SIGN: The SIGNs for infection
Title | DC-SIGN and L-SIGN: The SIGNs for infection |
---|---|
Authors | |
Keywords | Association study Infection Lectins Molecular genetics Population genetics Structural biology |
Issue Date | 2008 |
Publisher | Springer. The Journal's web site is located at http://www.springer.com/biomed/molecular/journal/109 |
Citation | Journal Of Molecular Medicine, 2008, v. 86 n. 8, p. 861-874 How to Cite? |
Abstract | Two closely related trans-membrane C-type lectins dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin (DC-SIGN or CD209) and liver/lymph node-specific ICAM-3 grabbing non-integrin (L-SIGN also known as DC-SIGNR, CD209L or CLEC4M) directly recognize a wide range of micro-organisms of major impact on public health. Both genes have long been considered to share similar overall structure and ligand-binding characteristics. This review presents more recent biochemical and structural studies, which show that they have distinct ligand-binding properties and different physiological functions. Of importance in both these genes is the presence of an extra-cellular domain consisting of an extended neck region encoded by tandem repeats that support the carbohydrate-recognition domain, which plays a crucial role in influencing the pathogen-binding properties of these receptors. The notable difference between these two genes is in this extra-cellular domain. Whilst the tandem-neck-repeat region remains relatively constant size for DC-SIGN, there is considerable polymorphism for L-SIGN. Homo-oligomerization of the neck region of L-SIGN has been shown to be important for high-affinity ligand binding, and heterozygous expression of the polymorphic variants of L-SIGN in which neck lengths differ could thus affect ligand-binding affinity. Functional studies on the effect of this tandem-neck-repeat region on pathogen-binding, as well as genetic association studies for various infectious diseases and among different populations, are discussed. Worldwide demographic data of the tandem-neck-repeat region showing distinct differences in the neck-region allele and genotype distribution among different ethnic groups are presented. These findings support the neck region as an excellent candidate acting as a functional target for selective pressures exerted by pathogens. © 2008 Springer-Verlag. |
Persistent Identifier | http://hdl.handle.net/10722/132492 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.422 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khoo, US | en_HK |
dc.contributor.author | Chan, KYK | en_HK |
dc.contributor.author | Chan, VSF | en_HK |
dc.contributor.author | Lin, CLS | en_HK |
dc.date.accessioned | 2011-03-28T09:25:21Z | - |
dc.date.available | 2011-03-28T09:25:21Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Journal Of Molecular Medicine, 2008, v. 86 n. 8, p. 861-874 | en_HK |
dc.identifier.issn | 0946-2716 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/132492 | - |
dc.description.abstract | Two closely related trans-membrane C-type lectins dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin (DC-SIGN or CD209) and liver/lymph node-specific ICAM-3 grabbing non-integrin (L-SIGN also known as DC-SIGNR, CD209L or CLEC4M) directly recognize a wide range of micro-organisms of major impact on public health. Both genes have long been considered to share similar overall structure and ligand-binding characteristics. This review presents more recent biochemical and structural studies, which show that they have distinct ligand-binding properties and different physiological functions. Of importance in both these genes is the presence of an extra-cellular domain consisting of an extended neck region encoded by tandem repeats that support the carbohydrate-recognition domain, which plays a crucial role in influencing the pathogen-binding properties of these receptors. The notable difference between these two genes is in this extra-cellular domain. Whilst the tandem-neck-repeat region remains relatively constant size for DC-SIGN, there is considerable polymorphism for L-SIGN. Homo-oligomerization of the neck region of L-SIGN has been shown to be important for high-affinity ligand binding, and heterozygous expression of the polymorphic variants of L-SIGN in which neck lengths differ could thus affect ligand-binding affinity. Functional studies on the effect of this tandem-neck-repeat region on pathogen-binding, as well as genetic association studies for various infectious diseases and among different populations, are discussed. Worldwide demographic data of the tandem-neck-repeat region showing distinct differences in the neck-region allele and genotype distribution among different ethnic groups are presented. These findings support the neck region as an excellent candidate acting as a functional target for selective pressures exerted by pathogens. © 2008 Springer-Verlag. | en_HK |
dc.language | eng | en_US |
dc.publisher | Springer. The Journal's web site is located at http://www.springer.com/biomed/molecular/journal/109 | - |
dc.relation.ispartof | Journal of Molecular Medicine | en_HK |
dc.rights | Journal of Molecular Medicine. Copyright © Elsevier Ireland Ltd. | - |
dc.subject | Association study | en_HK |
dc.subject | Infection | en_HK |
dc.subject | Lectins | en_HK |
dc.subject | Molecular genetics | en_HK |
dc.subject | Population genetics | en_HK |
dc.subject | Structural biology | en_HK |
dc.subject.mesh | Alternative Splicing | en_HK |
dc.subject.mesh | Amino Acid Sequence | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Cell Adhesion Molecules - chemistry - genetics - physiology | en_HK |
dc.subject.mesh | Dendritic Cells - immunology | en_HK |
dc.subject.mesh | Disease Susceptibility - immunology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Infection - genetics | en_HK |
dc.subject.mesh | Lectins, C-Type - chemistry - genetics - physiology | en_HK |
dc.subject.mesh | Ligands | en_HK |
dc.subject.mesh | Models, Biological | en_HK |
dc.subject.mesh | Molecular Sequence Data | en_HK |
dc.subject.mesh | Protein Isoforms - chemistry - genetics - metabolism | en_HK |
dc.subject.mesh | Receptors, Cell Surface - chemistry - genetics - physiology | en_HK |
dc.title | DC-SIGN and L-SIGN: The SIGNs for infection | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Khoo, US:uskhoo@hkucc.hku.hk | en_HK |
dc.identifier.email | Chan, KYK:kelvinc@pathology.hku.hk | en_HK |
dc.identifier.email | Chan, VSF:sfvchan@hku.hk | en_HK |
dc.identifier.authority | Khoo, US=rp00362 | en_HK |
dc.identifier.authority | Chan, KYK=rp00453 | en_HK |
dc.identifier.authority | Chan, VSF=rp01459 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s00109-008-0350-2 | en_HK |
dc.identifier.pmid | 18458800 | - |
dc.identifier.scopus | eid_2-s2.0-48149094568 | en_HK |
dc.identifier.hkuros | 145272 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-48149094568&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 86 | en_HK |
dc.identifier.issue | 8 | en_HK |
dc.identifier.spage | 861 | en_HK |
dc.identifier.epage | 874 | en_HK |
dc.identifier.isi | WOS:000257945800002 | - |
dc.identifier.scopusauthorid | Khoo, US=7004195799 | en_HK |
dc.identifier.scopusauthorid | Chan, KYK=7406034195 | en_HK |
dc.identifier.scopusauthorid | Chan, VSF=35200370000 | en_HK |
dc.identifier.scopusauthorid | Lin, CLS=37099293900 | en_HK |
dc.identifier.issnl | 0946-2716 | - |