File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.4049/jimmunol.165.1.75
- Scopus: eid_2-s2.0-0034235813
- PMID: 10861037
- WOS: WOS:000087816800012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Subtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitis
Title | Subtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitis |
---|---|
Authors | |
Keywords | Chemicals And Cas Registry Numbers |
Issue Date | 2000 |
Publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org |
Citation | Journal Of Immunology, 2000, v. 165 n. 1, p. 75-82 How to Cite? |
Abstract | The presence of potentially autoreactive T cells is a necessary, but not sufficient, condition for the development of autoimmune disease. However, the relationship between T cell response and susceptibility to disease is not straightforward. In this report, we use experimental allergic encephalomyelitis as a model to demonstrate that subtle alterations of the T cell response to an encephalitogenic epitope are sufficient to cause a dramatic decrease in disease susceptibility. Transgenic expression of a fusion protein of hen egg lysozyme and an encephalitogenic peptide of myelin basic protein (MBP) residues 84-105, coexpressed with MHC class H, causes profound tolerance to hen egg lysozyme, while maintaining a near normal response to MBP. Detailed analysis of the T cell repertoire of transgenic animals using a panel of T cell hybridomas revealed a highly selective loss of one minor component of the response to the MBP84-104 region. Despite this, transgenic animals were highly resistant to experimental allergic encephalomyelitis induction with the MBP peptide, indicating that minor changes to the T cell repertoire may result in major alterations in disease susceptibility. Possible reasons for this are discussed. |
Persistent Identifier | http://hdl.handle.net/10722/132504 |
ISSN | 2021 Impact Factor: 5.426 2020 SCImago Journal Rankings: 2.737 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vowles, C | en_HK |
dc.contributor.author | Chan, VSF | en_HK |
dc.contributor.author | Bodmer, HC | en_HK |
dc.date.accessioned | 2011-03-28T09:25:30Z | - |
dc.date.available | 2011-03-28T09:25:30Z | - |
dc.date.issued | 2000 | en_HK |
dc.identifier.citation | Journal Of Immunology, 2000, v. 165 n. 1, p. 75-82 | en_HK |
dc.identifier.issn | 0022-1767 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/132504 | - |
dc.description.abstract | The presence of potentially autoreactive T cells is a necessary, but not sufficient, condition for the development of autoimmune disease. However, the relationship between T cell response and susceptibility to disease is not straightforward. In this report, we use experimental allergic encephalomyelitis as a model to demonstrate that subtle alterations of the T cell response to an encephalitogenic epitope are sufficient to cause a dramatic decrease in disease susceptibility. Transgenic expression of a fusion protein of hen egg lysozyme and an encephalitogenic peptide of myelin basic protein (MBP) residues 84-105, coexpressed with MHC class H, causes profound tolerance to hen egg lysozyme, while maintaining a near normal response to MBP. Detailed analysis of the T cell repertoire of transgenic animals using a panel of T cell hybridomas revealed a highly selective loss of one minor component of the response to the MBP84-104 region. Despite this, transgenic animals were highly resistant to experimental allergic encephalomyelitis induction with the MBP peptide, indicating that minor changes to the T cell repertoire may result in major alterations in disease susceptibility. Possible reasons for this are discussed. | en_HK |
dc.language | eng | en_US |
dc.publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org | en_HK |
dc.relation.ispartof | Journal of Immunology | en_HK |
dc.subject | Chemicals And Cas Registry Numbers | en_US |
dc.subject.mesh | Amino Acid Sequence | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Antigen Presentation - genetics | en_HK |
dc.subject.mesh | Antigen-Presenting Cells - immunology - metabolism | en_HK |
dc.subject.mesh | Disease Susceptibility | en_HK |
dc.subject.mesh | Encephalomyelitis, Autoimmune, Experimental - genetics - immunology | en_HK |
dc.subject.mesh | Epitopes, T-Lymphocyte - immunology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Histocompatibility Antigens Class II - genetics - immunology - metabolism | en_HK |
dc.subject.mesh | Mice | en_HK |
dc.subject.mesh | Mice, Inbred Strains | en_HK |
dc.subject.mesh | Mice, Transgenic | en_HK |
dc.subject.mesh | Molecular Sequence Data | en_HK |
dc.subject.mesh | Muramidase - genetics - immunology - metabolism | en_HK |
dc.subject.mesh | Myelin Basic Proteins - genetics - immunology - metabolism | en_HK |
dc.subject.mesh | Peptide Fragments - genetics - immunology - metabolism | en_HK |
dc.subject.mesh | Spleen - cytology | en_HK |
dc.subject.mesh | T-Lymphocytes - immunology - metabolism | en_HK |
dc.subject.mesh | Transgenes - immunology | en_HK |
dc.title | Subtle effects on myelin basic protein-specific T cell responses can lead to a major reduction in disease susceptibility in experimental allergic encephalomyelitis | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chan, VSF:sfvchan@hku.hk | en_HK |
dc.identifier.authority | Chan, VSF=rp01459 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.4049/jimmunol.165.1.75 | - |
dc.identifier.pmid | 10861037 | - |
dc.identifier.scopus | eid_2-s2.0-0034235813 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034235813&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 165 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 75 | en_HK |
dc.identifier.epage | 82 | en_HK |
dc.identifier.isi | WOS:000087816800012 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Vowles, C=8234331000 | en_HK |
dc.identifier.scopusauthorid | Chan, VSF=35200370000 | en_HK |
dc.identifier.scopusauthorid | Bodmer, HC=6701765081 | en_HK |
dc.identifier.issnl | 0022-1767 | - |