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- Publisher Website: 10.1016/j.phrs.2011.09.010
- Scopus: eid_2-s2.0-84856019163
- PMID: 22005391
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Article: Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet
Title | Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet | ||||||||
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Authors | |||||||||
Keywords | Cholesterol Hamster Myogenic constriction Ovariectomy Raloxifene Septal coronary arteries | ||||||||
Issue Date | 2012 | ||||||||
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618 | ||||||||
Citation | Pharmacological Research, 2012, v. 65 n. 2, p. 182-188 How to Cite? | ||||||||
Abstract | Although vascular effects of selective estrogen receptor modulators (SERMs) have been extensively examined in conduit arteries, whether SERMs could favorably modulate myogenic response in resistance arteries is unknown. The impact of raloxifene therapy and cholesterol diet on myogenic constriction during estrogen deficiency is unresolved. This study investigated changes in vascular reactivity and myogenic responses in female ovariectomized (Ovx) hamsters fed high-cholesterol diet (HCD) with and without chronic treatment of raloxifene. Functional studies were performed on hamster septal coronary arteries cannulated in a pressure myograph. Acetylcholine (ACh)-induced dilatation was reduced in arteries from cholesterol-fed Ovx hamsters, but not in those from cholesterol-fed hamsters, while pressure-induced myogenic constriction was unaffected. Chronic treatment with raloxifene restored ACh-induced dilatation in cholesterol-fed Ovx hamsters. U46619-induced constriction was increased in arteries from cholesterol-fed Ovx hamsters but not from cholesterol-fed control hamsters, which was normalized by chronic raloxifene treatment. The pressure-diameter relationship is presented as normalized diameter versus intraluminal pressure, while the effect of ACh or U46619 is expressed as percentage of tone at 80 mmHg. Two-way analysis of variance (ANOVA) followed by Bonferroni post-tests were used for statistical evaluation among different treatment groups. P < 0.05 was taken as statistically significant. The present results show that chronic treatment with raloxifene could benefit myogenically active coronary arteries by (i) restoring ACh-induced dilatation and (ii) reducing U46619-induced constriction without affecting pressure-induced myogenic responses in cholesterol-fed hamsters during estrogen deficiency. If such benefit can be observed in humans, raloxifene and other SERMs may be useful to preserve endothelial function and curtail vascular hypersensitivity in resistance coronary arteries in post-menopausal women with hypercholesterolemia or hyperlipidemia, a lipid condition implicated in the pathogenesis of myocardial infarction. © 2011 Elsevier Ltd. All rights reserved. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/134638 | ||||||||
ISSN | 2023 Impact Factor: 9.1 2023 SCImago Journal Rankings: 2.160 | ||||||||
ISI Accession Number ID |
Funding Information: This study was supported by Research Grants Council of Hong Kong (4362/04M), National Basic Research Program of China (2012CB517805) and CUHK Focused Investment Scheme. | ||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, YC | en_HK |
dc.contributor.author | Leung, FP | en_HK |
dc.contributor.author | Tian, XY | en_HK |
dc.contributor.author | Yung, LM | en_HK |
dc.contributor.author | Lau, CW | en_HK |
dc.contributor.author | Chen, ZY | en_HK |
dc.contributor.author | Yao, X | en_HK |
dc.contributor.author | Laher, I | en_HK |
dc.contributor.author | Huang, Y | en_HK |
dc.date.accessioned | 2011-07-05T01:44:13Z | - |
dc.date.available | 2011-07-05T01:44:13Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Pharmacological Research, 2012, v. 65 n. 2, p. 182-188 | en_HK |
dc.identifier.issn | 1043-6618 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/134638 | - |
dc.description.abstract | Although vascular effects of selective estrogen receptor modulators (SERMs) have been extensively examined in conduit arteries, whether SERMs could favorably modulate myogenic response in resistance arteries is unknown. The impact of raloxifene therapy and cholesterol diet on myogenic constriction during estrogen deficiency is unresolved. This study investigated changes in vascular reactivity and myogenic responses in female ovariectomized (Ovx) hamsters fed high-cholesterol diet (HCD) with and without chronic treatment of raloxifene. Functional studies were performed on hamster septal coronary arteries cannulated in a pressure myograph. Acetylcholine (ACh)-induced dilatation was reduced in arteries from cholesterol-fed Ovx hamsters, but not in those from cholesterol-fed hamsters, while pressure-induced myogenic constriction was unaffected. Chronic treatment with raloxifene restored ACh-induced dilatation in cholesterol-fed Ovx hamsters. U46619-induced constriction was increased in arteries from cholesterol-fed Ovx hamsters but not from cholesterol-fed control hamsters, which was normalized by chronic raloxifene treatment. The pressure-diameter relationship is presented as normalized diameter versus intraluminal pressure, while the effect of ACh or U46619 is expressed as percentage of tone at 80 mmHg. Two-way analysis of variance (ANOVA) followed by Bonferroni post-tests were used for statistical evaluation among different treatment groups. P < 0.05 was taken as statistically significant. The present results show that chronic treatment with raloxifene could benefit myogenically active coronary arteries by (i) restoring ACh-induced dilatation and (ii) reducing U46619-induced constriction without affecting pressure-induced myogenic responses in cholesterol-fed hamsters during estrogen deficiency. If such benefit can be observed in humans, raloxifene and other SERMs may be useful to preserve endothelial function and curtail vascular hypersensitivity in resistance coronary arteries in post-menopausal women with hypercholesterolemia or hyperlipidemia, a lipid condition implicated in the pathogenesis of myocardial infarction. © 2011 Elsevier Ltd. All rights reserved. | en_HK |
dc.language | eng | - |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618 | en_HK |
dc.relation.ispartof | Pharmacological Research | en_HK |
dc.subject | Cholesterol | en_HK |
dc.subject | Hamster | en_HK |
dc.subject | Myogenic constriction | en_HK |
dc.subject | Ovariectomy | en_HK |
dc.subject | Raloxifene | en_HK |
dc.subject | Septal coronary arteries | en_HK |
dc.title | Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1043-6618&volume=&spage=&epage=&date=2010&atitle=Raloxifene+improves+vascular+reactivity+in+pressurized+septal+coronary+arteries+of+ovariectomized+hamsters+fed+cholesterol+diet | - |
dc.identifier.email | Chan, YC:yauchi@graduate.hku.hk | en_HK |
dc.identifier.authority | Chan, YC=rp01502 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.phrs.2011.09.010 | en_HK |
dc.identifier.pmid | 22005391 | - |
dc.identifier.scopus | eid_2-s2.0-84856019163 | en_HK |
dc.identifier.hkuros | 174015 | - |
dc.identifier.hkuros | 203417 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84856019163&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 65 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 182 | en_HK |
dc.identifier.epage | 188 | en_HK |
dc.identifier.isi | WOS:000301868300005 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Chan, YC=7403676116 | en_HK |
dc.identifier.scopusauthorid | Leung, FP=8615375300 | en_HK |
dc.identifier.scopusauthorid | Tian, XY=35768379500 | en_HK |
dc.identifier.scopusauthorid | Yung, LM=13807768200 | en_HK |
dc.identifier.scopusauthorid | Lau, CW=7401968520 | en_HK |
dc.identifier.scopusauthorid | Chen, ZY=53663102300 | en_HK |
dc.identifier.scopusauthorid | Yao, X=7402529434 | en_HK |
dc.identifier.scopusauthorid | Laher, I=7005431686 | en_HK |
dc.identifier.scopusauthorid | Huang, Y=34770945300 | en_HK |
dc.identifier.citeulike | 9910938 | - |
dc.identifier.issnl | 1043-6618 | - |