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Patent History
- ApplicationPCT/CN2009073204 2009-08-12
- PublicationWO 2011017837 2011-02-17
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published patent: NATIVE CHEMICAL LIGATION AT SERINE AND THREONINE SITES
Title | NATIVE CHEMICAL LIGATION AT SERINE AND THREONINE SITES |
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Priority Date | 2009-08-12 PCT/CN2009073204 |
Inventors | |
Issue Date | 2011 |
Citation | WO Published patent application WO 2011017837. World Intellectual Property Organization (WIPO), PatentScope, 2011 How to Cite? |
Abstract | A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (Fig. 1 (a)): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond. |
Persistent Identifier | http://hdl.handle.net/10722/142722 |
References |
DC Field | Value | Language |
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dc.date.accessioned | 2011-10-28T02:54:45Z | - |
dc.date.available | 2011-10-28T02:54:45Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | WO Published patent application WO 2011017837. World Intellectual Property Organization (WIPO), PatentScope, 2011 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/142722 | - |
dc.description.abstract | A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (Fig. 1 (a)): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond. | en_HK |
dc.language | eng | en_US |
dc.relation.isreferencedby | WO 2012041451 (A1) 2012-04-05 | en_HK |
dc.title | NATIVE CHEMICAL LIGATION AT SERINE AND THREONINE SITES | en_HK |
dc.type | Patent | en_US |
dc.identifier.email | Li, XC: xuechenl@hku.hk | en_US |
dc.identifier.authority | Li, XC=rp00742 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.hkuros | 197666 | en_US |
dc.contributor.inventor | LI, XUECHEN | en_HK |
patents.identifier.application | PCT/CN2009073204 | en_HK |
patents.description.assignee | LI XUECHEN [CN] | en_HK |
patents.description.country | World Intellectual Property Organization (WIPO) | en_HK |
patents.date.publication | 2011-02-17 | en_HK |
dc.relation.references | WO 0220557 (A1) 2002-03-14 | en_HK |
patents.date.application | 2009-08-12 | en_HK |
patents.date.priority | 2009-08-12 PCT/CN2009073204 | en_HK |
patents.description.cc | WO | en_HK |
patents.identifier.publication | WO 2011017837 | en_HK |
patents.relation.family | CN 102482320 (A) 2012-05-30 | en_HK |
patents.description.kind | A1 | en_HK |
patents.type | Patent_published | en_HK |