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Article: Systemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbits
Title | Systemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbits |
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Authors | |
Keywords | Hemodilution Myocardial Ischemia Rabbits Reperfusion Systemic Ischemic Preconditioning |
Issue Date | 2004 |
Publisher | Elsevier BV. The Journal's web site is located at http://intl-icvts.ctsnetjournals.org |
Citation | Interactive Cardiovascular And Thoracic Surgery, 2004, v. 3 n. 3, p. 528-532 How to Cite? |
Abstract | We investigated whether transient systemic ischemia can precondition the heart against the ensuing ischemic insult. Rabbits were randomly divided into systemic ischemic preconditioning (SIP), hemodilution (HD) and control (C) groups. SIP was induced by rapidly withdrawing blood from femoral artery and maintaining the mean artery pressure at 50 mmHg for 10 min. Afterwards, 50% of the withdrawn blood was re-infused with equal volumes of 6% deferoxamine- conjugated hydroxyethyl-starch (D-HES). Hemodilution in HD group was achieved by withdrawing blood at 8 ml/kg accompanied by concomitant infusion of equal volumes of D-HES. Animals were subjected to 30 min of coronary artery occlusion followed by 120 min of reperfusion. Cardiac output (CO) (thermodilution method), plasma malondialdehyde and nitric oxide content were measured at baseline and until 120 (R 120) min of reperfusion. At R 120, CO in group-C was significantly lower than its baseline value, accompanied by a significant reduction in nitric oxide production and increase in malondialdehyde concentration; CO in group-SIP and group-HD maintained at baseline levels throughout reperfusion. At R 120, CO in group-SIP, but not in group-HD, was significantly higher than that in group-C. It is concluded that transient SIP followed by hemodilution with D-HES facilitates early functional recovery of the ischemic-reperfused rabbit hearts. © 2004 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/147253 |
ISSN | 2023 Impact Factor: 1.6 2020 SCImago Journal Rankings: 0.546 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xia, Z | en_US |
dc.contributor.author | Xia, R | en_US |
dc.contributor.author | Lan, HT | en_US |
dc.contributor.author | Luo, T | en_US |
dc.contributor.author | Tang, QZ | en_US |
dc.contributor.author | Xia, ZY | en_US |
dc.contributor.author | Liu, XY | en_US |
dc.date.accessioned | 2012-05-29T06:01:03Z | - |
dc.date.available | 2012-05-29T06:01:03Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Interactive Cardiovascular And Thoracic Surgery, 2004, v. 3 n. 3, p. 528-532 | en_US |
dc.identifier.issn | 1569-9293 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147253 | - |
dc.description.abstract | We investigated whether transient systemic ischemia can precondition the heart against the ensuing ischemic insult. Rabbits were randomly divided into systemic ischemic preconditioning (SIP), hemodilution (HD) and control (C) groups. SIP was induced by rapidly withdrawing blood from femoral artery and maintaining the mean artery pressure at 50 mmHg for 10 min. Afterwards, 50% of the withdrawn blood was re-infused with equal volumes of 6% deferoxamine- conjugated hydroxyethyl-starch (D-HES). Hemodilution in HD group was achieved by withdrawing blood at 8 ml/kg accompanied by concomitant infusion of equal volumes of D-HES. Animals were subjected to 30 min of coronary artery occlusion followed by 120 min of reperfusion. Cardiac output (CO) (thermodilution method), plasma malondialdehyde and nitric oxide content were measured at baseline and until 120 (R 120) min of reperfusion. At R 120, CO in group-C was significantly lower than its baseline value, accompanied by a significant reduction in nitric oxide production and increase in malondialdehyde concentration; CO in group-SIP and group-HD maintained at baseline levels throughout reperfusion. At R 120, CO in group-SIP, but not in group-HD, was significantly higher than that in group-C. It is concluded that transient SIP followed by hemodilution with D-HES facilitates early functional recovery of the ischemic-reperfused rabbit hearts. © 2004 Elsevier B.V. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://intl-icvts.ctsnetjournals.org | en_US |
dc.relation.ispartof | Interactive Cardiovascular and Thoracic Surgery | en_US |
dc.subject | Hemodilution | en_US |
dc.subject | Myocardial Ischemia | en_US |
dc.subject | Rabbits | en_US |
dc.subject | Reperfusion | en_US |
dc.subject | Systemic Ischemic Preconditioning | en_US |
dc.title | Systemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbits | en_US |
dc.type | Article | en_US |
dc.identifier.email | Xia, Z:zyxia@hkucc.hku.hk | en_US |
dc.identifier.authority | Xia, Z=rp00532 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.icvts.2004.05.007 | en_US |
dc.identifier.scopus | eid_2-s2.0-4143143069 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-4143143069&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 528 | en_US |
dc.identifier.epage | 532 | en_US |
dc.publisher.place | Netherlands | en_US |
dc.identifier.issnl | 1569-9285 | - |