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- Publisher Website: 10.1007/BF01659097
- Scopus: eid_2-s2.0-0027730076
- PMID: 8109119
- WOS: WOS:A1993MN65800018
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Article: The pathological basis of resection margin for hepatocellular carcinoma
Title | The pathological basis of resection margin for hepatocellular carcinoma |
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Authors | |
Issue Date | 1993 |
Publisher | Springer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/ |
Citation | World Journal Of Surgery, 1993, v. 17 n. 6, p. 786-791 How to Cite? |
Abstract | At the time of hepatectomy for primary hepatocellular carcinoma (HCC), the necessary amount of surrounding nontumorous liver to be sacrificed, or the resection margin, which will ensure a complete histologic disease clearance is uncertain. Twenty-three resected liver specimens were studied by serial section followed by histological examination prospectively. All histologic diseases identified were assumed to spread radially in all directions from a unicentric lesion. Histologic disease from capsular and liver invasion was found confined to the immediate surrounding liver parenchyma. Eleven of the 14 large (≥5 cm) tumors and all six small (<5 cm) HCCs had either microsatellites and/or histologic venous permeation found beyond 1 cm from the lesion. A large tumor, multinodular lesions, macroscopic venous thrombi, liver invasion, and nonencapsulation were associated with an extensive spread of histologic disease. In the presence of either microsatellites or histologic venous permeation, no distance could ensure a complete disease clearance. |
Persistent Identifier | http://hdl.handle.net/10722/147993 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 0.772 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lai, ECS | en_US |
dc.contributor.author | You, KT | en_US |
dc.contributor.author | Ng, IOL | en_US |
dc.contributor.author | Shek, TWH | en_US |
dc.contributor.author | Braasch, JW | en_US |
dc.date.accessioned | 2012-05-29T06:10:16Z | - |
dc.date.available | 2012-05-29T06:10:16Z | - |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | World Journal Of Surgery, 1993, v. 17 n. 6, p. 786-791 | en_US |
dc.identifier.issn | 0364-2313 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147993 | - |
dc.description.abstract | At the time of hepatectomy for primary hepatocellular carcinoma (HCC), the necessary amount of surrounding nontumorous liver to be sacrificed, or the resection margin, which will ensure a complete histologic disease clearance is uncertain. Twenty-three resected liver specimens were studied by serial section followed by histological examination prospectively. All histologic diseases identified were assumed to spread radially in all directions from a unicentric lesion. Histologic disease from capsular and liver invasion was found confined to the immediate surrounding liver parenchyma. Eleven of the 14 large (≥5 cm) tumors and all six small (<5 cm) HCCs had either microsatellites and/or histologic venous permeation found beyond 1 cm from the lesion. A large tumor, multinodular lesions, macroscopic venous thrombi, liver invasion, and nonencapsulation were associated with an extensive spread of histologic disease. In the presence of either microsatellites or histologic venous permeation, no distance could ensure a complete disease clearance. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/ | en_US |
dc.relation.ispartof | World Journal of Surgery | en_US |
dc.subject.mesh | Carcinoma, Hepatocellular - Pathology - Surgery | en_US |
dc.subject.mesh | Hepatectomy - Methods | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver Neoplasms - Pathology - Surgery | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.title | The pathological basis of resection margin for hepatocellular carcinoma | en_US |
dc.type | Article | en_US |
dc.identifier.email | Ng, IOL:iolng@hkucc.hku.hk | en_US |
dc.identifier.authority | Ng, IOL=rp00335 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/BF01659097 | en_US |
dc.identifier.pmid | 8109119 | - |
dc.identifier.scopus | eid_2-s2.0-0027730076 | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 786 | en_US |
dc.identifier.epage | 791 | en_US |
dc.identifier.isi | WOS:A1993MN65800018 | - |
dc.publisher.place | United States | en_US |
dc.identifier.issnl | 0364-2313 | - |