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Article: In situ detection of Epstein-Barr virus markers in nasopharyngeal carcinoma patients

TitleIn situ detection of Epstein-Barr virus markers in nasopharyngeal carcinoma patients
Authors
Lung, MLChan, KHLam, WPKou, SKChoy, DChan, CWNg, MH
KeywordsEpstein–Barr virus
In situ
Nasopharyngeal carcinoma
Issue Date1989
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCL
Citation
Oncology, 1989, v. 46 n. 5, p. 310-317 How to Cite?
AbstractCryosections of nasopharyngeal tissue from 9 patients suspected of having nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Bar virus (EBV) markers in situ to assess virus infection in the nasopharynx. Viral DNA, EB nuclear antigen, and/or early antigens (EA.D and EA.R) were detected in 5 NPC specimens. EBV infection was not confined to the tumor areas of the biopsy specimens. Lymphoid cells and nontumor areas of these specimens contained EBV markers. In addition, nasopharyngeal tissues obtained from 3 of 4 patients in clinical remission for the disease showed evidence of EBV infection.
Persistent Identifierhttp://hdl.handle.net/10722/150688
ISSN
0030-2414
2021 Impact Factor: 3.734
2020 SCImago Journal Rankings: 0.987
ISI Accession Number ID
WOS:A1989AP22500007

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorLam, WPen_US
dc.contributor.authorKou, SKen_US
dc.contributor.authorChoy, Den_US
dc.contributor.authorChan, CWen_US
dc.contributor.authorNg, MHen_US
dc.date.accessioned2012-06-26T06:08:47Z-
dc.date.available2012-06-26T06:08:47Z-
dc.date.issued1989en_US
dc.identifier.citationOncology, 1989, v. 46 n. 5, p. 310-317en_US
dc.identifier.issn0030-2414en_US
dc.identifier.urihttp://hdl.handle.net/10722/150688-
dc.description.abstractCryosections of nasopharyngeal tissue from 9 patients suspected of having nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Bar virus (EBV) markers in situ to assess virus infection in the nasopharynx. Viral DNA, EB nuclear antigen, and/or early antigens (EA.D and EA.R) were detected in 5 NPC specimens. EBV infection was not confined to the tumor areas of the biopsy specimens. Lymphoid cells and nontumor areas of these specimens contained EBV markers. In addition, nasopharyngeal tissues obtained from 3 of 4 patients in clinical remission for the disease showed evidence of EBV infection.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCLen_US
dc.relation.ispartofOncologyen_US
dc.subjectEpstein–Barr virus-
dc.subjectIn situ-
dc.subjectNasopharyngeal carcinoma-
dc.subject.meshAntibodies, Monoclonal - Diagnostic Useen_US
dc.subject.meshAntigens, Viral - Analysisen_US
dc.subject.meshBiopsyen_US
dc.subject.meshDna, Viral - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshHerpesvirus 4, Humanen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMucous Membrane - Microbiologyen_US
dc.subject.meshNasopharyngeal Neoplasms - Immunology - Microbiologyen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.titleIn situ detection of Epstein-Barr virus markers in nasopharyngeal carcinoma patientsen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2550863-
dc.identifier.scopuseid_2-s2.0-0024446456en_US
dc.identifier.volume46en_US
dc.identifier.issue5en_US
dc.identifier.spage310en_US
dc.identifier.epage317en_US
dc.identifier.isiWOS:A1989AP22500007-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.scopusauthoridChan, KH=35338760600en_US
dc.identifier.scopusauthoridLam, WP=7203021904en_US
dc.identifier.scopusauthoridKou, SK=7102161483en_US
dc.identifier.scopusauthoridChoy, D=7102939127en_US
dc.identifier.scopusauthoridChan, CW=7404813871en_US
dc.identifier.scopusauthoridNg, MH=7202076421en_US
dc.identifier.issnl0030-2414-

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