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- Publisher Website: 10.1007/s11046-009-9217-5
- Scopus: eid_2-s2.0-70350370772
- PMID: 19544010
- WOS: WOS:000270742500002
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Article: Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke
Title | Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke | ||||||||
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Authors | |||||||||
Keywords | Candida albicans Cigarette smoke Virulence | ||||||||
Issue Date | 2009 | ||||||||
Publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-486X | ||||||||
Citation | Mycopathologia, 2009, v. 168 n. 5, p. 227-235 How to Cite? | ||||||||
Abstract | The habit of cigarette smoking is associated with higher oral candidal carriage and possible predisposition to oral candidosis. The effects of exposure to smoke on the virulence properties of oral yeasts remain obscure. Hence, we showed in vitro the effect of cigarette smoke condensate (CSC) on ten clinical isolates of Candida albicans obtained from nonsmoking volunteers, as well the type-strain CBS562. CSC was generated by complete burn of five commercial cigarettes in an in-house smoking machine and used to prepare the culture broth in which the strains were grown. In 24-h intervals (T24, T48, and T72), the cells were harvested, washed, subcultured, and the resultant growth were evaluated for possible variations for secreted aspartyl protease, phospholipase, chondroitinase, and hemolysins, adhesion to acrylic and cell surface hydrophobicity (CSH). The results indicated a temporal increase in the secretion rates of enzymes, particularly when yeast cells were exposed to CSC for 48-72h (P < 0.05). Similarly, adhesion to acrylic and CSH increased with exposure period (P < 0.05). Based on foregoing, we concluded that CSC may promote significant enhance in the secretion of candidal histolytic enzymes and adherence to denture surfaces, thereby promoting oral yeast carriage and possible infection. © Springer Science+Business Media B.V. 2009. | ||||||||
Persistent Identifier | http://hdl.handle.net/10722/154590 | ||||||||
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 0.743 | ||||||||
ISI Accession Number ID |
Funding Information: This study was conducted using intramural funds from The Pontifical Catholic University of Parana (PUCPR) and The University of Hong Kong (HKU). It was part of the Scientific Initiation Program of F.B.B. that was granted by the National Council of Technological and Scientific Development (CNPq). D.B. is a research fellow supported by the Scientific Initiation Program of PUCPR. | ||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baboni, FB | en_US |
dc.contributor.author | Barp, D | en_US |
dc.contributor.author | De Azevedo Izidoro, ACS | en_US |
dc.contributor.author | Samaranayake, LP | en_US |
dc.contributor.author | Rosa, EAR | en_US |
dc.date.accessioned | 2012-08-08T08:26:22Z | - |
dc.date.available | 2012-08-08T08:26:22Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Mycopathologia, 2009, v. 168 n. 5, p. 227-235 | en_US |
dc.identifier.issn | 0301-486X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/154590 | - |
dc.description.abstract | The habit of cigarette smoking is associated with higher oral candidal carriage and possible predisposition to oral candidosis. The effects of exposure to smoke on the virulence properties of oral yeasts remain obscure. Hence, we showed in vitro the effect of cigarette smoke condensate (CSC) on ten clinical isolates of Candida albicans obtained from nonsmoking volunteers, as well the type-strain CBS562. CSC was generated by complete burn of five commercial cigarettes in an in-house smoking machine and used to prepare the culture broth in which the strains were grown. In 24-h intervals (T24, T48, and T72), the cells were harvested, washed, subcultured, and the resultant growth were evaluated for possible variations for secreted aspartyl protease, phospholipase, chondroitinase, and hemolysins, adhesion to acrylic and cell surface hydrophobicity (CSH). The results indicated a temporal increase in the secretion rates of enzymes, particularly when yeast cells were exposed to CSC for 48-72h (P < 0.05). Similarly, adhesion to acrylic and CSH increased with exposure period (P < 0.05). Based on foregoing, we concluded that CSC may promote significant enhance in the secretion of candidal histolytic enzymes and adherence to denture surfaces, thereby promoting oral yeast carriage and possible infection. © Springer Science+Business Media B.V. 2009. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0301-486X | en_US |
dc.relation.ispartof | Mycopathologia | en_US |
dc.subject | Candida albicans | - |
dc.subject | Cigarette smoke | - |
dc.subject | Virulence | - |
dc.subject.mesh | Aspartic Acid Proteases - Metabolism | en_US |
dc.subject.mesh | Candida Albicans - Drug Effects - Enzymology - Growth & Development - Metabolism - Pathogenicity | en_US |
dc.subject.mesh | Candidiasis, Oral - Microbiology | en_US |
dc.subject.mesh | Chondroitinases And Chondroitin Lyases - Metabolism | en_US |
dc.subject.mesh | Hemolysin Proteins - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hydrophobic And Hydrophilic Interactions | en_US |
dc.subject.mesh | Phospholipases - Metabolism | en_US |
dc.subject.mesh | Smoke | en_US |
dc.subject.mesh | Smoking | en_US |
dc.subject.mesh | Virulence - Drug Effects | en_US |
dc.title | Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke | en_US |
dc.type | Article | en_US |
dc.identifier.email | Samaranayake, LP:lakshman@hku.hk | en_US |
dc.identifier.authority | Samaranayake, LP=rp00023 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s11046-009-9217-5 | en_US |
dc.identifier.pmid | 19544010 | - |
dc.identifier.scopus | eid_2-s2.0-70350370772 | en_US |
dc.identifier.hkuros | 166623 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-70350370772&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 168 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 227 | en_US |
dc.identifier.epage | 235 | en_US |
dc.identifier.isi | WOS:000270742500002 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Baboni, FB=35104430300 | en_US |
dc.identifier.scopusauthorid | Barp, D=35309256600 | en_US |
dc.identifier.scopusauthorid | de Azevedo Izidoro, ACS=23472880600 | en_US |
dc.identifier.scopusauthorid | Samaranayake, LP=7102761002 | en_US |
dc.identifier.scopusauthorid | Rosa, EAR=7004952748 | en_US |
dc.identifier.citeulike | 4940507 | - |
dc.identifier.issnl | 0301-486X | - |