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- Publisher Website: 10.1002/nbm.921
- Scopus: eid_2-s2.0-9244252480
- PMID: 15523704
- WOS: WOS:000225332500010
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Article: High-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Q
Title | High-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Q |
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Authors | |
Keywords | Angiogenesis Microvessel density Mouse brain MRI Superparamagnetic iron oxide contrast agent Transverse relaxation rate |
Issue Date | 2004 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087 |
Citation | Nmr In Biomedicine, 2004, v. 17 n. 7, p. 507-512 How to Cite? |
Abstract | Magnetic resonance imaging (MRI) is a powerful method for in vivo quantification of tissue properfies. It has been previously proposed that the index Q ≡ ΔR 2/(ΔR*2 2/3, where ΔR 2 and ΔR 2* are the spin echo and gradient echo relaxation rate shifts caused by the injection of an intravascular contrast agent, may be useful for characterizing microvasculature. In particular, Q is expected to correlate well with the density of microvessels. This study presents high-resolution in vivo Q-maps of normal mouse brain obtained with a superparamagnetic iron oxide contrast agent at a field of level of 9.4 T. Normative Q values are derived for several regions of interest and significant interregional variations are observed. Microvessel densities estimated from the Q-maps are found to be in reasonable accord with histologically determined values. A possible application of Q-maps is the assessment of angiogenic activity in tumors. Copyright © 2004 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/155774 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Wu, EX | en_US |
dc.contributor.author | Tang, H | en_US |
dc.contributor.author | Jensen, JH | en_US |
dc.date.accessioned | 2012-08-08T08:35:17Z | - |
dc.date.available | 2012-08-08T08:35:17Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Nmr In Biomedicine, 2004, v. 17 n. 7, p. 507-512 | en_US |
dc.identifier.issn | 0952-3480 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/155774 | - |
dc.description.abstract | Magnetic resonance imaging (MRI) is a powerful method for in vivo quantification of tissue properfies. It has been previously proposed that the index Q ≡ ΔR 2/(ΔR*2 2/3, where ΔR 2 and ΔR 2* are the spin echo and gradient echo relaxation rate shifts caused by the injection of an intravascular contrast agent, may be useful for characterizing microvasculature. In particular, Q is expected to correlate well with the density of microvessels. This study presents high-resolution in vivo Q-maps of normal mouse brain obtained with a superparamagnetic iron oxide contrast agent at a field of level of 9.4 T. Normative Q values are derived for several regions of interest and significant interregional variations are observed. Microvessel densities estimated from the Q-maps are found to be in reasonable accord with histologically determined values. A possible application of Q-maps is the assessment of angiogenic activity in tumors. Copyright © 2004 John Wiley & Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087 | en_US |
dc.relation.ispartof | NMR in Biomedicine | en_US |
dc.subject | Angiogenesis | - |
dc.subject | Microvessel density | - |
dc.subject | Mouse brain | - |
dc.subject | MRI | - |
dc.subject | Superparamagnetic iron oxide contrast agent | - |
dc.subject | Transverse relaxation rate | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Brain - Anatomy & Histology - Blood Supply | en_US |
dc.subject.mesh | Cerebrovascular Circulation | en_US |
dc.subject.mesh | Contrast Media | en_US |
dc.subject.mesh | Ferric Compounds - Diagnostic Use | en_US |
dc.subject.mesh | Image Enhancement - Methods | en_US |
dc.subject.mesh | Image Interpretation, Computer-Assisted - Methods | en_US |
dc.subject.mesh | Magnetic Resonance Imaging - Methods | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Microcirculation - Anatomy & Histology | en_US |
dc.title | High-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Q | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wu, EX:ewu1@hkucc.hku.hk | en_US |
dc.identifier.authority | Wu, EX=rp00193 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/nbm.921 | en_US |
dc.identifier.pmid | 15523704 | en_US |
dc.identifier.scopus | eid_2-s2.0-9244252480 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-9244252480&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 507 | en_US |
dc.identifier.epage | 512 | en_US |
dc.identifier.isi | WOS:000225332500010 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Wu, EX=7202128034 | en_US |
dc.identifier.scopusauthorid | Tang, H=36827331000 | en_US |
dc.identifier.scopusauthorid | Jensen, JH=7404521984 | en_US |
dc.identifier.citeulike | 4210869 | - |
dc.identifier.issnl | 0952-3480 | - |