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Article: Acute leukaemia in acromegaly patients

TitleAcute leukaemia in acromegaly patients
Authors
Au, WYChow, WSLam, KSLKo, GTCCockram, CSKwong, YL
KeywordsAcromegaly
Acute leukaemia
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2000, v. 110 n. 4, p. 871-873 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.2000.02262.x
AbstractAcromegaly patients are known to have an increased risk of malignancies, especially colonic adenocarcinoma. This may be as a result of the growth-stimulating effect of growth hormone (GH). The clustering of leukaemia in children treated with GH has also caused concern. There have been a few reports of leukaemia in acromegaly patients. We report two patients with acute lymphoblastic leukaemia and one patient with acute myeloid leukaemia among 106 acromegaly patients treated over a 15-year period. Two of the cases received radiotherapy as part of their treatment. Adjusted for age and follow-up years, the incidence of leukaemia in this cohort is significantly higher than the general population. The incidence is also higher than would be expected as a result of radiotherapy alone, suggesting that GH may play a synergistic role.
Persistent Identifierhttp://hdl.handle.net/10722/162375
ISSN
0007-1048
2021 Impact Factor: 8.615
2020 SCImago Journal Rankings: 1.907
ISI Accession Number ID
WOS:000089857800016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorChow, WSen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorKo, GTCen_US
dc.contributor.authorCockram, CSen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:19:23Z-
dc.date.available2012-09-05T05:19:23Z-
dc.date.issued2000en_US
dc.identifier.citationBritish Journal Of Haematology, 2000, v. 110 n. 4, p. 871-873en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162375-
dc.description.abstractAcromegaly patients are known to have an increased risk of malignancies, especially colonic adenocarcinoma. This may be as a result of the growth-stimulating effect of growth hormone (GH). The clustering of leukaemia in children treated with GH has also caused concern. There have been a few reports of leukaemia in acromegaly patients. We report two patients with acute lymphoblastic leukaemia and one patient with acute myeloid leukaemia among 106 acromegaly patients treated over a 15-year period. Two of the cases received radiotherapy as part of their treatment. Adjusted for age and follow-up years, the incidence of leukaemia in this cohort is significantly higher than the general population. The incidence is also higher than would be expected as a result of radiotherapy alone, suggesting that GH may play a synergistic role.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subjectAcromegaly-
dc.subjectAcute leukaemia-
dc.subject.meshAcromegaly - Complications - Surgeryen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdenoma - Complications - Secretion - Surgeryen_US
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Transplantationen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGrowth Hormone - Secretionen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLeukemia - Complicationsen_US
dc.subject.meshLeukemia, Myeloid - Complications - Therapyen_US
dc.subject.meshLeukemia-Lymphoma, Adult T-Cell - Complications - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Neoplasms - Complications - Secretionen_US
dc.subject.meshRisken_US
dc.titleAcute leukaemia in acromegaly patientsen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2000.02262.xen_US
dc.identifier.pmid11054071-
dc.identifier.scopuseid_2-s2.0-0033760353en_US
dc.identifier.hkuros59921-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033760353&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume110en_US
dc.identifier.issue4en_US
dc.identifier.spage871en_US
dc.identifier.epage873en_US
dc.identifier.isiWOS:000089857800016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridChow, WS=7402281153en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridKo, GTC=7103172871en_US
dc.identifier.scopusauthoridCockram, CS=7006379262en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.issnl0007-1048-

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