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- Publisher Website: 10.1160/TH10-05-0269
- Scopus: eid_2-s2.0-77954362697
- PMID: 20539907
- WOS: WOS:000280298300007
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Article: Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases
Title | Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases |
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Authors | |
Keywords | Drug screening Human induced pluripotent stem cells In vitro disease models Reprogramming |
Issue Date | 2010 |
Publisher | Schattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com |
Citation | Thrombosis And Haemostasis, 2010, v. 104 n. 1, p. 39-44 How to Cite? |
Abstract | Recent advances in stem cell biology have transformed the understanding of cell physiology and developmental biology such that it can now play a more prominent role in the clinical application of stem cell and regenerative medicine. Success in the generation of human induced pluripotent stem cells (iPS) as well as related emerging technology on the iPS platform provide great promise in the development of regenerative medicine. Human iPS cells show almost identical properties to human embryonic stem cells (ESC) in pluripotency, but avoid many of their limitations of use. In addition, investigations into reprogramming of somatic cells to pluripotent stem cells facilitate a deeper understanding of human stem cell biology. The iPS cell technology has offered a unique platform for studying the pathogenesis of human disease, pharmacological and toxicological testing, and cell-based therapy. Nevertheless, significant challenges remain to be overcome before the promise of human iPS cell technology can be realised. © Schattauer 2010. |
Persistent Identifier | http://hdl.handle.net/10722/163323 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 1.248 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Lian, Q | en_US |
dc.contributor.author | Chow, Y | en_US |
dc.contributor.author | Esteban, MA | en_US |
dc.contributor.author | Pei, D | en_US |
dc.contributor.author | Tse, HF | en_US |
dc.date.accessioned | 2012-09-05T05:30:03Z | - |
dc.date.available | 2012-09-05T05:30:03Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Thrombosis And Haemostasis, 2010, v. 104 n. 1, p. 39-44 | en_US |
dc.identifier.issn | 0340-6245 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163323 | - |
dc.description.abstract | Recent advances in stem cell biology have transformed the understanding of cell physiology and developmental biology such that it can now play a more prominent role in the clinical application of stem cell and regenerative medicine. Success in the generation of human induced pluripotent stem cells (iPS) as well as related emerging technology on the iPS platform provide great promise in the development of regenerative medicine. Human iPS cells show almost identical properties to human embryonic stem cells (ESC) in pluripotency, but avoid many of their limitations of use. In addition, investigations into reprogramming of somatic cells to pluripotent stem cells facilitate a deeper understanding of human stem cell biology. The iPS cell technology has offered a unique platform for studying the pathogenesis of human disease, pharmacological and toxicological testing, and cell-based therapy. Nevertheless, significant challenges remain to be overcome before the promise of human iPS cell technology can be realised. © Schattauer 2010. | en_US |
dc.language | eng | en_US |
dc.publisher | Schattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com | en_US |
dc.relation.ispartof | Thrombosis and Haemostasis | en_US |
dc.subject | Drug screening | - |
dc.subject | Human induced pluripotent stem cells | - |
dc.subject | In vitro disease models | - |
dc.subject | Reprogramming | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cardiovascular Diseases - Diagnosis - Pathology - Physiopathology - Therapy | en_US |
dc.subject.mesh | Drug Evaluation, Preclinical | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Induced Pluripotent Stem Cells - Metabolism - Pathology | en_US |
dc.subject.mesh | Regenerative Medicine | en_US |
dc.subject.mesh | Tissue Therapy - Trends | en_US |
dc.title | Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lian, Q:qzlian@hkucc.hku.hk | en_US |
dc.identifier.email | Tse, HF:hftse@hkucc.hku.hk | en_US |
dc.identifier.authority | Lian, Q=rp00267 | en_US |
dc.identifier.authority | Tse, HF=rp00428 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1160/TH10-05-0269 | en_US |
dc.identifier.pmid | 20539907 | - |
dc.identifier.scopus | eid_2-s2.0-77954362697 | en_US |
dc.identifier.hkuros | 204424 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77954362697&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 104 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 39 | en_US |
dc.identifier.epage | 44 | en_US |
dc.identifier.isi | WOS:000280298300007 | - |
dc.publisher.place | Germany | en_US |
dc.identifier.scopusauthorid | Lian, Q=7003399023 | en_US |
dc.identifier.scopusauthorid | Chow, Y=35784012900 | en_US |
dc.identifier.scopusauthorid | Esteban, MA=35591774300 | en_US |
dc.identifier.scopusauthorid | Pei, D=7102806599 | en_US |
dc.identifier.scopusauthorid | Tse, HF=7006070805 | en_US |
dc.identifier.issnl | 0340-6245 | - |