File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.hrthm.2012.01.007
- Scopus: eid_2-s2.0-84862777690
- PMID: 22245798
- WOS: WOS:000304242900019
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Subclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in patients with coronary artery disease and fragmented QRS complex
Title | Subclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in patients with coronary artery disease and fragmented QRS complex |
---|---|
Authors | |
Keywords | Coronary Artery Disease Fragmented Qrs Strain Strain Rate |
Issue Date | 2012 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/heartrhythmjournal |
Citation | Heart Rhythm, 2012, v. 9 n. 6, p. 928-935 How to Cite? |
Abstract | Background: Fragmented QRS (fQRS) complexes on a routine 12-lead electrocardiogram were associated with adverse cardiac events, including sudden death in patients with coronary artery disease (CAD). Objective: To investigate the relationship between the fQRS complex and global and regional left ventricular (LV) functions in patients with CAD. Methods: The study consisted of 176 patients (68 ± 9 years; 145 [82%] men) with CAD with narrow QRS duration and preserved LV ejection fraction (>45%). All patients underwent detailed 2-dimensional speckle-tracking echocardiography to determine global and segmental (basal, middle, and apical) LV strains and strain rates and were prospectively followed-up in the outpatient clinic. Results: Fifty-five patients (31%) had fQRS complexes. Global, middle, and apical LV longitudinal, radial, and circumferential strains and strain rates were significantly lower in the fQRS group than in the non-fQRS group (all P <.05). Multivariate logistic regression analysis revealed that the fQRS complex was associated with decreased global circumferential strain (odds ratio 1.19; 95% confidence interval 1.06-1.33; P =.003) and multivessel disease (odds ratio 3.69; 95% confidence interval 1.35-10.08; P =.011). Kaplan-Meier analysis revealed that event-free survival for cardiac events was significantly lower in the fQRS group than in the non-fQRS group (P =.036). Conclusions: Our results demonstrated that the fQRS complex in patients with CAD with preserved LV ejection fraction was associated with subclinical global and regional LV dysfunctions as detected by 2-dimensional speckle-tracking imaging, and the results also predicted adverse cardiac events. © 2012 Heart Rhythm Society. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/163501 |
ISSN | 2023 Impact Factor: 5.6 2023 SCImago Journal Rankings: 2.072 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yan, GH | en_US |
dc.contributor.author | Wang, M | en_US |
dc.contributor.author | Yiu, KH | en_US |
dc.contributor.author | Lau, CP | en_US |
dc.contributor.author | Zhi, G | en_US |
dc.contributor.author | Lee, SWL | en_US |
dc.contributor.author | Siu, CW | en_US |
dc.contributor.author | Tse, HF | en_US |
dc.date.accessioned | 2012-09-05T05:32:24Z | - |
dc.date.available | 2012-09-05T05:32:24Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Heart Rhythm, 2012, v. 9 n. 6, p. 928-935 | en_US |
dc.identifier.issn | 1547-5271 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163501 | - |
dc.description.abstract | Background: Fragmented QRS (fQRS) complexes on a routine 12-lead electrocardiogram were associated with adverse cardiac events, including sudden death in patients with coronary artery disease (CAD). Objective: To investigate the relationship between the fQRS complex and global and regional left ventricular (LV) functions in patients with CAD. Methods: The study consisted of 176 patients (68 ± 9 years; 145 [82%] men) with CAD with narrow QRS duration and preserved LV ejection fraction (>45%). All patients underwent detailed 2-dimensional speckle-tracking echocardiography to determine global and segmental (basal, middle, and apical) LV strains and strain rates and were prospectively followed-up in the outpatient clinic. Results: Fifty-five patients (31%) had fQRS complexes. Global, middle, and apical LV longitudinal, radial, and circumferential strains and strain rates were significantly lower in the fQRS group than in the non-fQRS group (all P <.05). Multivariate logistic regression analysis revealed that the fQRS complex was associated with decreased global circumferential strain (odds ratio 1.19; 95% confidence interval 1.06-1.33; P =.003) and multivessel disease (odds ratio 3.69; 95% confidence interval 1.35-10.08; P =.011). Kaplan-Meier analysis revealed that event-free survival for cardiac events was significantly lower in the fQRS group than in the non-fQRS group (P =.036). Conclusions: Our results demonstrated that the fQRS complex in patients with CAD with preserved LV ejection fraction was associated with subclinical global and regional LV dysfunctions as detected by 2-dimensional speckle-tracking imaging, and the results also predicted adverse cardiac events. © 2012 Heart Rhythm Society. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/heartrhythmjournal | en_US |
dc.relation.ispartof | Heart Rhythm | en_US |
dc.subject | Coronary Artery Disease | en_US |
dc.subject | Fragmented Qrs | en_US |
dc.subject | Strain | en_US |
dc.subject | Strain Rate | en_US |
dc.title | Subclinical left ventricular dysfunction revealed by circumferential 2D strain imaging in patients with coronary artery disease and fragmented QRS complex | en_US |
dc.type | Article | en_US |
dc.identifier.email | Siu, CW:cwdsiu@hkucc.hku.hk | en_US |
dc.identifier.email | Tse, HF:hftse@hkucc.hku.hk | en_US |
dc.identifier.authority | Siu, CW=rp00534 | en_US |
dc.identifier.authority | Tse, HF=rp00428 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.hrthm.2012.01.007 | en_US |
dc.identifier.pmid | 22245798 | - |
dc.identifier.scopus | eid_2-s2.0-84862777690 | en_US |
dc.identifier.hkuros | 218478 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862777690&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 928 | en_US |
dc.identifier.epage | 935 | en_US |
dc.identifier.isi | WOS:000304242900019 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Yan, GH=36544693600 | en_US |
dc.identifier.scopusauthorid | Wang, M=55032544200 | en_US |
dc.identifier.scopusauthorid | Yiu, KH=55035807600 | en_US |
dc.identifier.scopusauthorid | Lau, CP=35275317200 | en_US |
dc.identifier.scopusauthorid | Zhi, G=7003672763 | en_US |
dc.identifier.scopusauthorid | Lee, SWL=7601396808 | en_US |
dc.identifier.scopusauthorid | Siu, CW=7006550690 | en_US |
dc.identifier.scopusauthorid | Tse, HF=7006070805 | en_US |
dc.identifier.issnl | 1547-5271 | - |