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- Publisher Website: 10.1093/europace/eur389
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- PMID: 22183750
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Article: Frequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events
Title | Frequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events |
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Authors | |
Keywords | Atrial Fibrillation And Stroke Premature Atrial Complexes |
Issue Date | 2012 |
Publisher | Oxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/ |
Citation | Europace, 2012, v. 14 n. 7, p. 942-947 How to Cite? |
Abstract | AimsTo investigate the relation between baseline frequency of premature atrial complexes (PACs) and new atrial fibrillation (AF) and adverse cardiovascular events.Method and resultsFour hundred and twenty-eight patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations, dizziness, or syncope were recruited. One hundred and seven patients with number of PACs at the top quartile (i.e. >100PACs/day) were defined to have frequent PACs. After 6.1-year follow-up, 31 patients (29) with frequent PACs developed AF compared with 29 patients (9) with PACs ≤100/day (P< 0.01). Cox regression analysis revealed that frequent PACs [hazard ratio (HR): 3.22 (95 confidence interval (CI): 1.95.5; P< 0.001)], age >75 years (HR: 2.3; 95 CI: 1.33.9; P 0.004), and coronary artery disease (HR: 2.5; 95 CI: 1.44.4; P 0.002) were independent predictors for new AF. Concerning the composite endpoint (ischaemic stroke, heart failure, and death), patients with frequent PACs were more at risk than those without (34.5 vs. 19.3) (HR: 1.95; 95 CI: 1.373.50; P 0.001). Cox regression analysis showed that age >75 years (HR: 2.2; 95 CI: 1.473.41; P< 0.001), coronary artery disease (HR: 2.2, 95 CI: 1.423.44, P< 0.001), and frequent PACs (HR: 1.6; 95 CI: 1.042.44; P 0.03) were independent predictors for the secondary composite endpoint.ConclusionFrequent PACs predict new AF and adverse cardiovascular events. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.2011 © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. |
Persistent Identifier | http://hdl.handle.net/10722/163505 |
ISSN | 2023 Impact Factor: 7.9 2023 SCImago Journal Rankings: 2.895 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chong, BH | en_US |
dc.contributor.author | Pong, V | en_US |
dc.contributor.author | Lam, KF | en_US |
dc.contributor.author | Liu, S | en_US |
dc.contributor.author | Zuo, ML | en_US |
dc.contributor.author | Lau, YF | en_US |
dc.contributor.author | Lau, CP | en_US |
dc.contributor.author | Tse, HF | en_US |
dc.contributor.author | Siu, CW | en_US |
dc.date.accessioned | 2012-09-05T05:32:41Z | - |
dc.date.available | 2012-09-05T05:32:41Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Europace, 2012, v. 14 n. 7, p. 942-947 | en_US |
dc.identifier.issn | 1099-5129 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163505 | - |
dc.description.abstract | AimsTo investigate the relation between baseline frequency of premature atrial complexes (PACs) and new atrial fibrillation (AF) and adverse cardiovascular events.Method and resultsFour hundred and twenty-eight patients without AF or structural heart disease undergoing 24 h electrocardiography monitoring for palpitations, dizziness, or syncope were recruited. One hundred and seven patients with number of PACs at the top quartile (i.e. >100PACs/day) were defined to have frequent PACs. After 6.1-year follow-up, 31 patients (29) with frequent PACs developed AF compared with 29 patients (9) with PACs ≤100/day (P< 0.01). Cox regression analysis revealed that frequent PACs [hazard ratio (HR): 3.22 (95 confidence interval (CI): 1.95.5; P< 0.001)], age >75 years (HR: 2.3; 95 CI: 1.33.9; P 0.004), and coronary artery disease (HR: 2.5; 95 CI: 1.44.4; P 0.002) were independent predictors for new AF. Concerning the composite endpoint (ischaemic stroke, heart failure, and death), patients with frequent PACs were more at risk than those without (34.5 vs. 19.3) (HR: 1.95; 95 CI: 1.373.50; P 0.001). Cox regression analysis showed that age >75 years (HR: 2.2; 95 CI: 1.473.41; P< 0.001), coronary artery disease (HR: 2.2, 95 CI: 1.423.44, P< 0.001), and frequent PACs (HR: 1.6; 95 CI: 1.042.44; P 0.03) were independent predictors for the secondary composite endpoint.ConclusionFrequent PACs predict new AF and adverse cardiovascular events. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011.2011 © Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. | en_US |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://europace.oxfordjournals.org/ | en_US |
dc.relation.ispartof | Europace | en_US |
dc.subject | Atrial Fibrillation And Stroke | en_US |
dc.subject | Premature Atrial Complexes | en_US |
dc.title | Frequent premature atrial complexes predict new occurrence of atrial fibrillation and adverse cardiovascular events | en_US |
dc.type | Article | en_US |
dc.identifier.email | Siu, CW:cwdsiu@hkucc.hku.hk | en_US |
dc.identifier.authority | Siu, CW=rp00534 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1093/europace/eur389 | en_US |
dc.identifier.pmid | 22183750 | - |
dc.identifier.scopus | eid_2-s2.0-84862979101 | en_US |
dc.identifier.hkuros | 222724 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862979101&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 942 | en_US |
dc.identifier.epage | 947 | en_US |
dc.identifier.isi | WOS:000305621000006 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Chong, BH=53263288800 | en_US |
dc.identifier.scopusauthorid | Pong, V=26025247300 | en_US |
dc.identifier.scopusauthorid | Lam, KF=55265945800 | en_US |
dc.identifier.scopusauthorid | Liu, S=55266582100 | en_US |
dc.identifier.scopusauthorid | Zuo, ML=54958367700 | en_US |
dc.identifier.scopusauthorid | Lau, YF=55266245900 | en_US |
dc.identifier.scopusauthorid | Lau, CP=35275317200 | en_US |
dc.identifier.scopusauthorid | Tse, HF=54886126900 | en_US |
dc.identifier.scopusauthorid | Siu, CW=7006550690 | en_US |
dc.identifier.issnl | 1099-5129 | - |