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- Publisher Website: 10.1021/bc049775d
- Scopus: eid_2-s2.0-18844389263
- PMID: 15898713
- WOS: WOS:000229274800003
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Article: Transferrin-mediated gold nanoparticle cellular uptake
Title | Transferrin-mediated gold nanoparticle cellular uptake |
---|---|
Authors | |
Issue Date | 2005 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc |
Citation | Bioconjugate Chemistry, 2005, v. 16 n. 3, p. 494-496 How to Cite? |
Abstract | Targeted drug delivery is an important research area in specific therapy. Transferrin-conjugated nanoparticles are an attractive formulation as a vehicle for specific cellular uptake and targeted drug delivery. In this report, atomic force microscopy imaging was used to visualize the process of cellular uptake of transferrin-coupled gold nanoparticles on the surfaces of live cells for the first time. High-resolution images were captured, showing the endocytosis of transferrin-conjugated nanoparticles taking place during the process of internalization. This specific transferrin-mediated nanoparticle uptake was validated by confocal scanning imaging and transferrin competition experiments. © 2005 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/167924 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.085 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, PH | en_US |
dc.contributor.author | Sun, X | en_US |
dc.contributor.author | Chiu, JF | en_US |
dc.contributor.author | Sun, H | en_US |
dc.contributor.author | He, QY | en_US |
dc.date.accessioned | 2012-10-08T03:12:59Z | - |
dc.date.available | 2012-10-08T03:12:59Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Bioconjugate Chemistry, 2005, v. 16 n. 3, p. 494-496 | en_US |
dc.identifier.issn | 1043-1802 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167924 | - |
dc.description.abstract | Targeted drug delivery is an important research area in specific therapy. Transferrin-conjugated nanoparticles are an attractive formulation as a vehicle for specific cellular uptake and targeted drug delivery. In this report, atomic force microscopy imaging was used to visualize the process of cellular uptake of transferrin-coupled gold nanoparticles on the surfaces of live cells for the first time. High-resolution images were captured, showing the endocytosis of transferrin-conjugated nanoparticles taking place during the process of internalization. This specific transferrin-mediated nanoparticle uptake was validated by confocal scanning imaging and transferrin competition experiments. © 2005 American Chemical Society. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/bc | en_US |
dc.relation.ispartof | Bioconjugate Chemistry | en_US |
dc.subject.mesh | Biological Transport | en_US |
dc.subject.mesh | Cell Line, Tumor | en_US |
dc.subject.mesh | Gold - Chemistry - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Microscopy, Atomic Force | en_US |
dc.subject.mesh | Microscopy, Confocal | en_US |
dc.subject.mesh | Nanostructures - Ultrastructure | en_US |
dc.subject.mesh | Transferrin - Chemistry - Metabolism - Ultrastructure | en_US |
dc.title | Transferrin-mediated gold nanoparticle cellular uptake | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sun, H:hsun@hkucc.hku.hk | en_US |
dc.identifier.authority | Sun, H=rp00777 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/bc049775d | en_US |
dc.identifier.pmid | 15898713 | - |
dc.identifier.scopus | eid_2-s2.0-18844389263 | en_US |
dc.identifier.hkuros | 98471 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-18844389263&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 494 | en_US |
dc.identifier.epage | 496 | en_US |
dc.identifier.isi | WOS:000229274800003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Yang, PH=8847694800 | en_US |
dc.identifier.scopusauthorid | Sun, X=8906547400 | en_US |
dc.identifier.scopusauthorid | Chiu, JF=7201501692 | en_US |
dc.identifier.scopusauthorid | Sun, H=7404827446 | en_US |
dc.identifier.scopusauthorid | He, QY=34770287900 | en_US |
dc.identifier.issnl | 1043-1802 | - |