File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1021/ja110115a
- Scopus: eid_2-s2.0-79551711838
- PMID: 21207981
- WOS: WOS:000287228500075
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides
Title | Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides |
---|---|
Authors | |
Issue Date | 2011 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html |
Citation | Journal Of The American Chemical Society, 2011, v. 133 n. 5, p. 1597-1602 How to Cite? |
Abstract | Described herein is a method for the joining of complex peptides to complex oligosaccharides via an N-linkage. The ω-aspartylation is conducted by coupling fully deprotected glycosylamine with a peptide containing a unique thioacid at the ω-aspartate carboxyl. In the presence of HOBT, under conditions that, in principle, allow for oxidation, complex components are combined in encouraging yields to produce structurally and stereochemically defined N-linked glycopolypeptides wherein the carbohydrate domain can be quite complex. Various mechanisms for oxidative coupling are proposed. © 2011 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/168506 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, P | en_US |
dc.contributor.author | Li, X | en_US |
dc.contributor.author | Zhu, J | en_US |
dc.contributor.author | Chen, J | en_US |
dc.contributor.author | Yuan, Y | en_US |
dc.contributor.author | Wu, X | en_US |
dc.contributor.author | Danishefsky, SJ | en_US |
dc.date.accessioned | 2012-10-08T03:19:47Z | - |
dc.date.available | 2012-10-08T03:19:47Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Journal Of The American Chemical Society, 2011, v. 133 n. 5, p. 1597-1602 | en_US |
dc.identifier.issn | 0002-7863 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168506 | - |
dc.description.abstract | Described herein is a method for the joining of complex peptides to complex oligosaccharides via an N-linkage. The ω-aspartylation is conducted by coupling fully deprotected glycosylamine with a peptide containing a unique thioacid at the ω-aspartate carboxyl. In the presence of HOBT, under conditions that, in principle, allow for oxidation, complex components are combined in encouraging yields to produce structurally and stereochemically defined N-linked glycopolypeptides wherein the carbohydrate domain can be quite complex. Various mechanisms for oxidative coupling are proposed. © 2011 American Chemical Society. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html | en_US |
dc.relation.ispartof | Journal of the American Chemical Society | en_US |
dc.subject.mesh | Amines - Chemistry | en_US |
dc.subject.mesh | Amino Acid Sequence | en_US |
dc.subject.mesh | Aspartic Acid - Chemistry | en_US |
dc.subject.mesh | Glycopeptides - Chemical Synthesis - Chemistry | en_US |
dc.subject.mesh | Nitrogen - Chemistry | en_US |
dc.subject.mesh | Oligosaccharides - Chemistry | en_US |
dc.title | Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, X:xuechenl@hku.hk | en_US |
dc.identifier.authority | Li, X=rp00742 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/ja110115a | en_US |
dc.identifier.pmid | 21207981 | - |
dc.identifier.scopus | eid_2-s2.0-79551711838 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79551711838&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 133 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 1597 | en_US |
dc.identifier.epage | 1602 | en_US |
dc.identifier.isi | WOS:000287228500075 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wang, P=35220801200 | en_US |
dc.identifier.scopusauthorid | Li, X=24168958800 | en_US |
dc.identifier.scopusauthorid | Zhu, J=8583321500 | en_US |
dc.identifier.scopusauthorid | Chen, J=35775129200 | en_US |
dc.identifier.scopusauthorid | Yuan, Y=35180688100 | en_US |
dc.identifier.scopusauthorid | Wu, X=26650236700 | en_US |
dc.identifier.scopusauthorid | Danishefsky, SJ=7202925243 | en_US |
dc.identifier.issnl | 0002-7863 | - |