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Article: Induced self-assembly and Förster resonance energy transfer studies of alkynylplatinum(II) terpyridine complex through interaction with water-soluble poly(phenylene ethynylene sulfonate) and the proof-of-principle demonstration of this two-component ensemble for selective label-free detection of human serum albumin
Title | Induced self-assembly and Förster resonance energy transfer studies of alkynylplatinum(II) terpyridine complex through interaction with water-soluble poly(phenylene ethynylene sulfonate) and the proof-of-principle demonstration of this two-component ensemble for selective label-free detection of human serum albumin |
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Authors | |
Issue Date | 2011 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html |
Citation | Journal of The American Chemical Society, 2011, v. 133 n. 46, p. 18775-18784 How to Cite? |
Abstract | The interaction of conjugated polyelectrolyte, PPE-SO3 -, with platinum(II) complexes, [Pt(tpy)(C≡CC6H 4-CH2NMe3-4)](OTf)2 (1) and [Pt(tpy)(C≡C-CH2NMe3)]-(OTf)2 (2), has been studied by UV-vis, and steady-state and time-resolved emission spectroscopy. A unique FRET from PPE-SO3 - to the aggregated complex 1 on the polymer chain with Pt···Pt interaction has been demonstrated, resulting in the growth of triplet metal-metal-to-ligand charge transfer (3MMLCT) emission in the near-infrared (NIR) region. This two-component ensemble has been employed in a "proof-ofprinciple" concept for the sensitive and selective label-free detection of human serum albumin (HSA) by the emission spectral changes in the visible and in the NIR region. The spectral changes have been ascribed to the disassembly of the polymer-metal complex aggregates upon the binding of PPE-SO3 - to HSA, which is rich in arginine residues and hydrophobic patches, leading to the decrease in FRET from PPE-SO 3 - to the aggregated platinum(II) complex. The ensemble is found to have high selectivity toward HSA over a number of polyelectrolytes, proteins and small amino acids. This has been suggested to be a result of the extra stabilization gained from the Pt··· Pt and π-π interactions in addition to the electrostatic and hydrophobic interactions found in the polymer-metal complex aggregates. © 2011 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/168594 |
ISSN | 2021 Impact Factor: 16.383 2020 SCImago Journal Rankings: 7.115 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, CYS | en_US |
dc.contributor.author | Yam, VWW | en_US |
dc.date.accessioned | 2012-10-08T03:21:17Z | - |
dc.date.available | 2012-10-08T03:21:17Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Journal of The American Chemical Society, 2011, v. 133 n. 46, p. 18775-18784 | en_US |
dc.identifier.issn | 0002-7863 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168594 | - |
dc.description.abstract | The interaction of conjugated polyelectrolyte, PPE-SO3 -, with platinum(II) complexes, [Pt(tpy)(C≡CC6H 4-CH2NMe3-4)](OTf)2 (1) and [Pt(tpy)(C≡C-CH2NMe3)]-(OTf)2 (2), has been studied by UV-vis, and steady-state and time-resolved emission spectroscopy. A unique FRET from PPE-SO3 - to the aggregated complex 1 on the polymer chain with Pt···Pt interaction has been demonstrated, resulting in the growth of triplet metal-metal-to-ligand charge transfer (3MMLCT) emission in the near-infrared (NIR) region. This two-component ensemble has been employed in a "proof-ofprinciple" concept for the sensitive and selective label-free detection of human serum albumin (HSA) by the emission spectral changes in the visible and in the NIR region. The spectral changes have been ascribed to the disassembly of the polymer-metal complex aggregates upon the binding of PPE-SO3 - to HSA, which is rich in arginine residues and hydrophobic patches, leading to the decrease in FRET from PPE-SO 3 - to the aggregated platinum(II) complex. The ensemble is found to have high selectivity toward HSA over a number of polyelectrolytes, proteins and small amino acids. This has been suggested to be a result of the extra stabilization gained from the Pt··· Pt and π-π interactions in addition to the electrostatic and hydrophobic interactions found in the polymer-metal complex aggregates. © 2011 American Chemical Society. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html | en_US |
dc.relation.ispartof | Journal of the American Chemical Society | en_US |
dc.rights | © 2011 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. | - |
dc.title | Induced self-assembly and Förster resonance energy transfer studies of alkynylplatinum(II) terpyridine complex through interaction with water-soluble poly(phenylene ethynylene sulfonate) and the proof-of-principle demonstration of this two-component ensemble for selective label-free detection of human serum albumin | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yam, VWW:wwyam@hku.hk | en_US |
dc.identifier.authority | Yam, VWW=rp00822 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1021/ja205996e | en_US |
dc.identifier.pmid | 22035316 | - |
dc.identifier.scopus | eid_2-s2.0-83055186864 | en_US |
dc.identifier.hkuros | 204651 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-83055186864&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 133 | en_US |
dc.identifier.issue | 46 | en_US |
dc.identifier.spage | 18775 | en_US |
dc.identifier.epage | 18784 | en_US |
dc.identifier.isi | WOS:000297398900049 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Chung, CYS=35169000200 | en_US |
dc.identifier.scopusauthorid | Yam, VWW=18539304700 | en_US |
dc.identifier.issnl | 0002-7863 | - |