File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1371/journal.pone.0030503
- Scopus: eid_2-s2.0-84857080131
- PMID: 22355314
- WOS: WOS:000302741300014
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Over-expression of PDGFR-β promotes PDGF-induced proliferation, migration, and angiogenesis of EPCs through PI3K/Akt signaling pathway
Title | Over-expression of PDGFR-β promotes PDGF-induced proliferation, migration, and angiogenesis of EPCs through PI3K/Akt signaling pathway |
---|---|
Authors | |
Issue Date | 2012 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action |
Citation | PLoS One, 2012, v. 7 n. 2 How to Cite? |
Abstract | The proliferation, migration, and angiogenesis of endothelial progenitor cells (EPCs) play critical roles in postnatal neovascularization and re-endothelialization following vascular injury. Here we evaluated whether the over-expression of platelet-derived growth factor receptor-β (PDGFR-β) can enhance the PDGF-BB-stimulated biological functions of EPCs through the PDGFR-β/phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. We first confirmed the expression of endogenous PDGFR-β and its plasma membrane localization in spleen-derived EPCs. We then demonstrated that the PDGFR-β over-expression in EPCs enhanced the PDGF-BB-induced proliferation, migration, and angiogenesis of EPCs. Using AG1295 (a PDGFR kinase inhibitor), LY294002 (a PI3K inhibitor), and sc-221226 (an Akt inhibitor), we further showed that the PI3K/Akt signaling pathway participates in the PDGF-BB-induced proliferation, migration, and angiogenesis of EPCs. In addition, the PI3K/Akt signaling pathway is required for PDGFR-β over-expression to enhance these PDGF-BB-induced phenotypes. © 2012 Wang et al. |
Persistent Identifier | http://hdl.handle.net/10722/168607 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.839 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, H | en_US |
dc.contributor.author | Yin, Y | en_US |
dc.contributor.author | Li, W | en_US |
dc.contributor.author | Zhao, X | en_US |
dc.contributor.author | Yu, Y | en_US |
dc.contributor.author | Zhu, J | en_US |
dc.contributor.author | Qin, Z | en_US |
dc.contributor.author | Wang, Q | en_US |
dc.contributor.author | Wang, K | en_US |
dc.contributor.author | Lu, W | en_US |
dc.contributor.author | Liu, J | en_US |
dc.contributor.author | Huang, L | en_US |
dc.date.accessioned | 2012-10-08T03:21:29Z | - |
dc.date.available | 2012-10-08T03:21:29Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | PLoS One, 2012, v. 7 n. 2 | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168607 | - |
dc.description.abstract | The proliferation, migration, and angiogenesis of endothelial progenitor cells (EPCs) play critical roles in postnatal neovascularization and re-endothelialization following vascular injury. Here we evaluated whether the over-expression of platelet-derived growth factor receptor-β (PDGFR-β) can enhance the PDGF-BB-stimulated biological functions of EPCs through the PDGFR-β/phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. We first confirmed the expression of endogenous PDGFR-β and its plasma membrane localization in spleen-derived EPCs. We then demonstrated that the PDGFR-β over-expression in EPCs enhanced the PDGF-BB-induced proliferation, migration, and angiogenesis of EPCs. Using AG1295 (a PDGFR kinase inhibitor), LY294002 (a PI3K inhibitor), and sc-221226 (an Akt inhibitor), we further showed that the PI3K/Akt signaling pathway participates in the PDGF-BB-induced proliferation, migration, and angiogenesis of EPCs. In addition, the PI3K/Akt signaling pathway is required for PDGFR-β over-expression to enhance these PDGF-BB-induced phenotypes. © 2012 Wang et al. | en_US |
dc.language | eng | en_US |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Over-expression of PDGFR-β promotes PDGF-induced proliferation, migration, and angiogenesis of EPCs through PI3K/Akt signaling pathway | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lu, W:luwei@hku.hk | en_US |
dc.identifier.authority | Lu, W=rp00754 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1371/journal.pone.0030503 | en_US |
dc.identifier.pmid | 22355314 | - |
dc.identifier.scopus | eid_2-s2.0-84857080131 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84857080131&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.isi | WOS:000302741300014 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wang, H=54993293300 | en_US |
dc.identifier.scopusauthorid | Yin, Y=54994935300 | en_US |
dc.identifier.scopusauthorid | Li, W=54992085900 | en_US |
dc.identifier.scopusauthorid | Zhao, X=54991119200 | en_US |
dc.identifier.scopusauthorid | Yu, Y=34979429100 | en_US |
dc.identifier.scopusauthorid | Zhu, J=54993766300 | en_US |
dc.identifier.scopusauthorid | Qin, Z=35211223400 | en_US |
dc.identifier.scopusauthorid | Wang, Q=54991952200 | en_US |
dc.identifier.scopusauthorid | Wang, K=54992506800 | en_US |
dc.identifier.scopusauthorid | Lu, W=27868087600 | en_US |
dc.identifier.scopusauthorid | Liu, J=54993503300 | en_US |
dc.identifier.scopusauthorid | Huang, L=34769889600 | en_US |
dc.identifier.issnl | 1932-6203 | - |