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- Publisher Website: 10.1002/hbm.20552
- Scopus: eid_2-s2.0-61449177904
- PMID: 18344177
- WOS: WOS:000264015900017
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Article: Masked smoking-related images modulate brain activity in smokers
Title | Masked smoking-related images modulate brain activity in smokers |
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Authors | |
Keywords | Addiction Amygdala Functional magnetic resonance imaging (fMRI) Smoking-related cue Unawareness |
Issue Date | 2009 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751 |
Citation | Human Brain Mapping, 2009, v. 30 n. 3, p. 896-907 How to Cite? |
Abstract | The questions of whether and how indiscriminate drug-related stimuli could influence drug- users are important to our understanding of addictive behavior, but the answers are still inconclusive. In the present preliminary functional magnetic resonance imaging study using a backward masking paradigm, the effect of indiscriminate smoking-related stimuli on 10 smokers and 10 nonsmokers was examined. The BOLD response showed a significant reduction (P = 0.001) in the right amygdala of smokers when they viewed but did not perceive masked smoking-related stimuli, while no significant differences were found in the nonsmoker group. More voxels in anterior cingulate cortex were negatively correlated with the amygdala during the masked smoking-related picture condition in smokers but not in nonsmokers, whereas more positively correlated voxels were observed during the masked neutral condition. The BOLD response in drug-users indicates the amygdala responds to drug-related stimuli that are below the perceptual threshold. The functional connectivity data suggest a functional interaction between the amygdala and the anterior cingulate cortex when drug users view 33ms back- masked drug-related stimuli. This observation suggests that the amygdala plays an important role in the indiscriminate drug-related cue process. © 2008 Wiley-Liss, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/169061 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.626 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, X | en_US |
dc.contributor.author | Chen, X | en_US |
dc.contributor.author | Yu, Y | en_US |
dc.contributor.author | Sun, D | en_US |
dc.contributor.author | Ning, M | en_US |
dc.contributor.author | He, S | en_US |
dc.contributor.author | Hu, X | en_US |
dc.contributor.author | Zhang, D | en_US |
dc.date.accessioned | 2012-10-08T03:41:20Z | - |
dc.date.available | 2012-10-08T03:41:20Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Human Brain Mapping, 2009, v. 30 n. 3, p. 896-907 | en_US |
dc.identifier.issn | 1065-9471 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169061 | - |
dc.description.abstract | The questions of whether and how indiscriminate drug-related stimuli could influence drug- users are important to our understanding of addictive behavior, but the answers are still inconclusive. In the present preliminary functional magnetic resonance imaging study using a backward masking paradigm, the effect of indiscriminate smoking-related stimuli on 10 smokers and 10 nonsmokers was examined. The BOLD response showed a significant reduction (P = 0.001) in the right amygdala of smokers when they viewed but did not perceive masked smoking-related stimuli, while no significant differences were found in the nonsmoker group. More voxels in anterior cingulate cortex were negatively correlated with the amygdala during the masked smoking-related picture condition in smokers but not in nonsmokers, whereas more positively correlated voxels were observed during the masked neutral condition. The BOLD response in drug-users indicates the amygdala responds to drug-related stimuli that are below the perceptual threshold. The functional connectivity data suggest a functional interaction between the amygdala and the anterior cingulate cortex when drug users view 33ms back- masked drug-related stimuli. This observation suggests that the amygdala plays an important role in the indiscriminate drug-related cue process. © 2008 Wiley-Liss, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751 | en_US |
dc.relation.ispartof | Human Brain Mapping | en_US |
dc.subject | Addiction | - |
dc.subject | Amygdala | - |
dc.subject | Functional magnetic resonance imaging (fMRI) | - |
dc.subject | Smoking-related cue | - |
dc.subject | Unawareness | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Behavior, Addictive - Physiopathology | en_US |
dc.subject.mesh | Brain - Physiopathology | en_US |
dc.subject.mesh | Brain Mapping | en_US |
dc.subject.mesh | Cues | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Image Processing, Computer-Assisted | en_US |
dc.subject.mesh | Magnetic Resonance Imaging | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Neural Pathways - Physiology | en_US |
dc.subject.mesh | Smoking - Physiopathology | en_US |
dc.subject.mesh | Tobacco Use Disorder - Physiopathology | en_US |
dc.title | Masked smoking-related images modulate brain activity in smokers | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sun, D:sundelin@hku.hk | en_US |
dc.identifier.authority | Sun, D=rp00873 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/hbm.20552 | en_US |
dc.identifier.pmid | 18344177 | - |
dc.identifier.scopus | eid_2-s2.0-61449177904 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-61449177904&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 896 | en_US |
dc.identifier.epage | 907 | en_US |
dc.identifier.isi | WOS:000264015900017 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Zhang, X=8570352000 | en_US |
dc.identifier.scopusauthorid | Chen, X=8570352100 | en_US |
dc.identifier.scopusauthorid | Yu, Y=7406250414 | en_US |
dc.identifier.scopusauthorid | Sun, D=25029722800 | en_US |
dc.identifier.scopusauthorid | Ning, M=36864617000 | en_US |
dc.identifier.scopusauthorid | He, S=7402691306 | en_US |
dc.identifier.scopusauthorid | Hu, X=34770364200 | en_US |
dc.identifier.scopusauthorid | Zhang, D=7405356250 | en_US |
dc.identifier.issnl | 1065-9471 | - |