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- Publisher Website: 10.1016/j.ydbio.2007.11.033
- Scopus: eid_2-s2.0-38849174513
- PMID: 18191119
- WOS: WOS:000253334000008
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Article: Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
Title | Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development |
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Authors | |
Keywords | Apoptosis Cell proliferation Fgfr1b Palatal fusion Palatal growth Palatogenesis Wnt11 Wnt11 siRNA z-VAD-fmk |
Issue Date | 2008 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio |
Citation | Developmental Biology, 2008, v. 314 n. 2, p. 341-350 How to Cite? |
Abstract | Various cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/169546 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 1.147 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, JM | en_US |
dc.contributor.author | Kim, JY | en_US |
dc.contributor.author | Cho, KW | en_US |
dc.contributor.author | Lee, MJ | en_US |
dc.contributor.author | Cho, SW | en_US |
dc.contributor.author | Kwak, S | en_US |
dc.contributor.author | Cai, J | en_US |
dc.contributor.author | Jung, HS | en_US |
dc.date.accessioned | 2012-10-25T04:52:45Z | - |
dc.date.available | 2012-10-25T04:52:45Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Developmental Biology, 2008, v. 314 n. 2, p. 341-350 | en_US |
dc.identifier.issn | 0012-1606 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169546 | - |
dc.description.abstract | Various cellular and molecular events underlie the elevation and fusion of the developing palate that occurs during embryonic development. This includes convergent extension, where the medial edge epithelium is intercalated into the midline epithelial seam. We examined the expression patterns of Wnt11 and Fgfr1b - which are believed to be key factors in convergent extension - in mouse palate development. Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures. The results suggested that interactions between Wnt11 and Fgfr1b are important in modulating cellular events such as cell proliferation for growth and apoptosis for fusion. Moreover, the Wnt11 siRNA results showed that Wnt11-induced apoptosis was necessary for palatal fusion. In summary, Fgfr1b induces cell proliferation in the developing palate mesenchyme so that the palate grows and contacts each palatal shelf, with negative feedback of Fgfs triggered by excessive cell proliferation then inhibiting the expression of Fgfr1b and activating the expression of Wnt11 to fuse each palate by activating apoptosis. © 2007 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio | en_US |
dc.relation.ispartof | Developmental Biology | en_US |
dc.subject | Apoptosis | - |
dc.subject | Cell proliferation | - |
dc.subject | Fgfr1b | - |
dc.subject | Palatal fusion | - |
dc.subject | Palatal growth | - |
dc.subject | Palatogenesis | - |
dc.subject | Wnt11 | - |
dc.subject | Wnt11 siRNA | - |
dc.subject | z-VAD-fmk | - |
dc.subject.mesh | Aging - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Electroporation | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | In Situ Hybridization | en_US |
dc.subject.mesh | Maxilla - Cytology - Growth & Development | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, Inbred Icr | en_US |
dc.subject.mesh | Organ Culture Techniques | en_US |
dc.subject.mesh | Palate - Cytology - Growth & Development | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Rna, Small Interfering - Genetics | en_US |
dc.subject.mesh | Receptor Cross-Talk - Physiology | en_US |
dc.subject.mesh | Receptor, Fibroblast Growth Factor, Type 1 - Genetics - Physiology | en_US |
dc.subject.mesh | Wnt Proteins - Genetics - Physiology | en_US |
dc.title | Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development | en_US |
dc.type | Article | en_US |
dc.identifier.email | Jung, HS: hsjung@yuhs.ac | en_US |
dc.identifier.authority | Jung, HS=rp01683 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.ydbio.2007.11.033 | en_US |
dc.identifier.pmid | 18191119 | - |
dc.identifier.scopus | eid_2-s2.0-38849174513 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-38849174513&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 314 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 341 | en_US |
dc.identifier.epage | 350 | en_US |
dc.identifier.isi | WOS:000253334000008 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lee, JM=25622544900 | en_US |
dc.identifier.scopusauthorid | Kim, JY=7601361822 | en_US |
dc.identifier.scopusauthorid | Cho, KW=7403956665 | en_US |
dc.identifier.scopusauthorid | Lee, MJ=35264472100 | en_US |
dc.identifier.scopusauthorid | Cho, SW=32967447200 | en_US |
dc.identifier.scopusauthorid | Kwak, S=7202607781 | en_US |
dc.identifier.scopusauthorid | Cai, J=9246458800 | en_US |
dc.identifier.scopusauthorid | Jung, HS=7403030195 | en_US |
dc.identifier.citeulike | 5650786 | - |
dc.identifier.issnl | 0012-1606 | - |