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- Publisher Website: 10.1016/j.neuroimage.2010.08.008
- Scopus: eid_2-s2.0-77957950710
- PMID: 20699124
- WOS: WOS:000283825000007
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Article: Factors underlying prefrontal and insula structural alterations in smokers
Title | Factors underlying prefrontal and insula structural alterations in smokers |
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Authors | |
Issue Date | 2011 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg |
Citation | Neuroimage, 2011, v. 54 n. 1, p. 42-48 How to Cite? |
Abstract | Based upon previous reports of alterations in white matter integrity and gray matter density in smokers, we examined these markers in a large, well-matched sample of smokers and non-smokers. We further investigated the effect of heavy cigarette exposure by using pack-years and the effects of two relatively stable, highly heritable traits in smokers (Fagerström Test of Nicotine Dependence (FTND), a measure of severity of nicotine dependence and Toronto Alexithymia Scale (TAS-20), a stable personality trait related to smoking). Forty-eight nicotine-dependent subjects and 48 matched controls were included in the analyses, with smokers also subdivided into high/low dependence and high/low pack-years smokers. White matter integrity (fractional anisotropy (FA)) and gray matter density (voxel-based morphometry (VBM)) were measured and compared across groups. Gray matter density was lower in left prefrontal cortex (PFC) in high pack-years smokers and was inversely related to pack-years. In contrast, left insular cortex gray matter density was higher in smokers and associated with TAS-20 total score and with difficulty-identifying-feelings factor. Further, the most highly dependent smokers showed lower prefrontal FA, which was negatively correlated with FTND. There was no correlation between pack-years and FTND in our smoker population. These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray matter and PFC white matter appear to reflect stable and heritable differences between smokers and non-smokers. © 2010. |
Persistent Identifier | http://hdl.handle.net/10722/169878 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 2.436 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, X | en_HK |
dc.contributor.author | Salmeron, BJ | en_HK |
dc.contributor.author | Ross, TJ | en_HK |
dc.contributor.author | Geng, X | en_HK |
dc.contributor.author | Yang, Y | en_HK |
dc.contributor.author | Stein, EA | en_HK |
dc.date.accessioned | 2012-10-25T04:57:32Z | - |
dc.date.available | 2012-10-25T04:57:32Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Neuroimage, 2011, v. 54 n. 1, p. 42-48 | en_HK |
dc.identifier.issn | 1053-8119 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/169878 | - |
dc.description.abstract | Based upon previous reports of alterations in white matter integrity and gray matter density in smokers, we examined these markers in a large, well-matched sample of smokers and non-smokers. We further investigated the effect of heavy cigarette exposure by using pack-years and the effects of two relatively stable, highly heritable traits in smokers (Fagerström Test of Nicotine Dependence (FTND), a measure of severity of nicotine dependence and Toronto Alexithymia Scale (TAS-20), a stable personality trait related to smoking). Forty-eight nicotine-dependent subjects and 48 matched controls were included in the analyses, with smokers also subdivided into high/low dependence and high/low pack-years smokers. White matter integrity (fractional anisotropy (FA)) and gray matter density (voxel-based morphometry (VBM)) were measured and compared across groups. Gray matter density was lower in left prefrontal cortex (PFC) in high pack-years smokers and was inversely related to pack-years. In contrast, left insular cortex gray matter density was higher in smokers and associated with TAS-20 total score and with difficulty-identifying-feelings factor. Further, the most highly dependent smokers showed lower prefrontal FA, which was negatively correlated with FTND. There was no correlation between pack-years and FTND in our smoker population. These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray matter and PFC white matter appear to reflect stable and heritable differences between smokers and non-smokers. © 2010. | en_HK |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg | en_HK |
dc.relation.ispartof | NeuroImage | en_HK |
dc.subject.mesh | Brain Damage, Chronic - Etiology | en_US |
dc.subject.mesh | Cerebral Cortex - Pathology | en_US |
dc.subject.mesh | Emotions | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Image Processing, Computer-Assisted - Methods | en_US |
dc.subject.mesh | Magnetic Resonance Imaging - Methods | en_US |
dc.subject.mesh | Nerve Degeneration - Pathology | en_US |
dc.subject.mesh | Prefrontal Cortex - Pathology | en_US |
dc.subject.mesh | Smoke - Adverse Effects | en_US |
dc.subject.mesh | Smoking - Genetics - Pathology - Psychology | en_US |
dc.subject.mesh | Thinking | en_US |
dc.title | Factors underlying prefrontal and insula structural alterations in smokers | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Geng, X: gengx@hku.hk | en_HK |
dc.identifier.authority | Geng, X=rp01678 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.neuroimage.2010.08.008 | en_HK |
dc.identifier.pmid | 20699124 | - |
dc.identifier.scopus | eid_2-s2.0-77957950710 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77957950710&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 54 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 42 | en_HK |
dc.identifier.epage | 48 | en_HK |
dc.identifier.isi | WOS:000283825000007 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Zhang, X=8570352000 | en_HK |
dc.identifier.scopusauthorid | Salmeron, BJ=6603367393 | en_HK |
dc.identifier.scopusauthorid | Ross, TJ=7203043487 | en_HK |
dc.identifier.scopusauthorid | Geng, X=34771310000 | en_HK |
dc.identifier.scopusauthorid | Yang, Y=7409387192 | en_HK |
dc.identifier.scopusauthorid | Stein, EA=7202194954 | en_HK |
dc.identifier.issnl | 1053-8119 | - |