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- Publisher Website: 10.1007/BF01957573
- Scopus: eid_2-s2.0-0026693064
- PMID: 1396930
- WOS: WOS:A1992JG58300011
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Article: Defective B-cell and regulatory T-cell function in Wiskott-Aldrich syndrome
Title | Defective B-cell and regulatory T-cell function in Wiskott-Aldrich syndrome |
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Authors | |
Keywords | Chinese lymphocytes platelets Wiskott-Aldrich syndrome |
Issue Date | 1992 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00431/index.htm |
Citation | European Journal Of Pediatrics, 1992, v. 151 n. 9, p. 680-683 How to Cite? |
Abstract | We report two Chinese boys with Wiskott-Aldrich syndrome presenting with gastro-intestinal bleeding, eczema and recurrent infection. They had thrombocytopenia and the mean platelet volume was small. Serum IgG and IgA were elevated and lymphocyte proliferation in response to phytohaemagglutinin, concanavalin A and pokeweed mitogen was defective. Despite documented herpes simplex virus type 1 and cytomegalovirus infection in one patient, he did not mount any humoral response. The generation of antibody-secreting cells in response to pokeweed mitogen was markedly defective in aplaque-forming cell assay. Both patients' regulatory T cell and B-cell functions were defective in this assay. The genetic defect in Wiskott-Aldrich syndrome therefore affects T-cells, B-cells and platelets. |
Persistent Identifier | http://hdl.handle.net/10722/170259 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.984 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lau, YL | en_HK |
dc.contributor.author | Jones, BM | en_HK |
dc.contributor.author | Low, LCK | en_HK |
dc.contributor.author | Wong, SN | en_HK |
dc.contributor.author | Leung, NK | en_HK |
dc.date.accessioned | 2012-10-30T06:07:02Z | - |
dc.date.available | 2012-10-30T06:07:02Z | - |
dc.date.issued | 1992 | en_HK |
dc.identifier.citation | European Journal Of Pediatrics, 1992, v. 151 n. 9, p. 680-683 | en_HK |
dc.identifier.issn | 0340-6199 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/170259 | - |
dc.description.abstract | We report two Chinese boys with Wiskott-Aldrich syndrome presenting with gastro-intestinal bleeding, eczema and recurrent infection. They had thrombocytopenia and the mean platelet volume was small. Serum IgG and IgA were elevated and lymphocyte proliferation in response to phytohaemagglutinin, concanavalin A and pokeweed mitogen was defective. Despite documented herpes simplex virus type 1 and cytomegalovirus infection in one patient, he did not mount any humoral response. The generation of antibody-secreting cells in response to pokeweed mitogen was markedly defective in aplaque-forming cell assay. Both patients' regulatory T cell and B-cell functions were defective in this assay. The genetic defect in Wiskott-Aldrich syndrome therefore affects T-cells, B-cells and platelets. | en_HK |
dc.language | eng | en_US |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00431/index.htm | en_HK |
dc.relation.ispartof | European Journal of Pediatrics | en_HK |
dc.subject | Chinese | en_HK |
dc.subject | lymphocytes | en_HK |
dc.subject | platelets | en_HK |
dc.subject | Wiskott-Aldrich syndrome | en_HK |
dc.subject.mesh | Antibody Formation | en_US |
dc.subject.mesh | B-Lymphocytes - Cytology - Physiology | en_US |
dc.subject.mesh | Cell Division | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infant | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | T-Lymphocytes - Cytology - Physiology | en_US |
dc.subject.mesh | Wiskott-Aldrich Syndrome - Genetics - Immunology - Pathology | en_US |
dc.title | Defective B-cell and regulatory T-cell function in Wiskott-Aldrich syndrome | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lau, YL: lauylung@hku.hk | en_HK |
dc.identifier.email | Low, LCK: lcklow@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.identifier.authority | Low, LCK=rp00337 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/BF01957573 | - |
dc.identifier.pmid | 1396930 | - |
dc.identifier.scopus | eid_2-s2.0-0026693064 | en_HK |
dc.identifier.volume | 151 | en_HK |
dc.identifier.issue | 9 | en_HK |
dc.identifier.spage | 680 | en_HK |
dc.identifier.epage | 683 | en_HK |
dc.identifier.isi | WOS:A1992JG58300011 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_HK |
dc.identifier.scopusauthorid | Jones, BM=7404958958 | en_HK |
dc.identifier.scopusauthorid | Low, LCK=7007049461 | en_HK |
dc.identifier.scopusauthorid | Wong, SN=7404590305 | en_HK |
dc.identifier.scopusauthorid | Leung, NK=55107144800 | en_HK |
dc.identifier.issnl | 0340-6199 | - |