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Article: Screening for (-(SEA)) α-globin gene deletion in β-thalassemia carriers and prevention of hydrops fetalis
Title | Screening for (-(SEA)) α-globin gene deletion in β-thalassemia carriers and prevention of hydrops fetalis |
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Authors | |
Keywords | α-Globin gene deletions β-Thalassemia Hydrops fetalis |
Issue Date | 2000 |
Citation | Haematologica, 2000, v. 85 n. 9, p. 991-993 How to Cite? |
Abstract | In Southeast Asia, where thalassemia is prevalent, heterozygous carriers of both β-thalassemia mutation and the (-(SEA)) α-globin gene deletion are encountered. These individuals are potentially at risk of being parents to off-springs affected by β-thalassemia major, hemoglobin (Hb) H disease, and Hb Bart's hydrops fetalis. We propose screening for the (-(SEA)) α-thalassemia mutation in all β-thalassemia carriers to prevent hydrops fetalis. |
Persistent Identifier | http://hdl.handle.net/10722/170301 |
ISSN | 2023 Impact Factor: 8.2 2023 SCImago Journal Rankings: 2.490 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ma, ESK | en_US |
dc.contributor.author | Chan, AYY | en_US |
dc.contributor.author | Shau Yin Ha | en_US |
dc.contributor.author | Chan, GCF | en_US |
dc.contributor.author | Yu Lung Lau | en_US |
dc.contributor.author | Li Chong Chan | en_US |
dc.date.accessioned | 2012-10-30T06:07:20Z | - |
dc.date.available | 2012-10-30T06:07:20Z | - |
dc.date.issued | 2000 | en_US |
dc.identifier.citation | Haematologica, 2000, v. 85 n. 9, p. 991-993 | en_US |
dc.identifier.issn | 0390-6078 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170301 | - |
dc.description.abstract | In Southeast Asia, where thalassemia is prevalent, heterozygous carriers of both β-thalassemia mutation and the (-(SEA)) α-globin gene deletion are encountered. These individuals are potentially at risk of being parents to off-springs affected by β-thalassemia major, hemoglobin (Hb) H disease, and Hb Bart's hydrops fetalis. We propose screening for the (-(SEA)) α-thalassemia mutation in all β-thalassemia carriers to prevent hydrops fetalis. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Haematologica | en_US |
dc.subject | α-Globin gene deletions | - |
dc.subject | β-Thalassemia | - |
dc.subject | Hydrops fetalis | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Asia, Southeastern - Epidemiology | en_US |
dc.subject.mesh | Child, Preschool | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Diseases - Genetics | en_US |
dc.subject.mesh | Gene Deletion | en_US |
dc.subject.mesh | Genetic Testing | en_US |
dc.subject.mesh | Globins - Genetics | en_US |
dc.subject.mesh | Heterozygote | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hydrops Fetalis - Genetics - Prevention & Control | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Beta-Thalassemia - Genetics | en_US |
dc.title | Screening for (-(SEA)) α-globin gene deletion in β-thalassemia carriers and prevention of hydrops fetalis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chan, GCF:gcfchan@hkucc.hku.hk | en_US |
dc.identifier.email | Yu Lung Lau:lauylung@hkucc.hku.hk | en_US |
dc.identifier.authority | Chan, GCF=rp00431 | en_US |
dc.identifier.authority | Yu Lung Lau=rp00361 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 10980643 | - |
dc.identifier.scopus | eid_2-s2.0-0033782529 | en_US |
dc.identifier.hkuros | 55819 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033782529&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 85 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.spage | 991 | en_US |
dc.identifier.epage | 993 | en_US |
dc.publisher.place | Italy | en_US |
dc.identifier.scopusauthorid | Ma, ESK=7202039934 | en_US |
dc.identifier.scopusauthorid | Chan, AYY=7403168182 | en_US |
dc.identifier.scopusauthorid | Shau Yin Ha=7409724064 | en_US |
dc.identifier.scopusauthorid | Chan, GCF=16160154400 | en_US |
dc.identifier.scopusauthorid | Yu Lung Lau=7201403380 | en_US |
dc.identifier.scopusauthorid | Li Chong Chan=7409519850 | en_US |
dc.identifier.issnl | 0390-6078 | - |