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Article: Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP

TitleModulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP
Authors
De Mey, JBurnstock, GVanhoutte, PM
KeywordsAdenosine
Adenosine β, γ-methylene-5′-triphosphate
Adenosine-5′-triphosphate
Adrenergic neurotransmission
Saphenous vein Purinergic receptors
Issue Date1979
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1979, v. 55 n. 4, p. 401-405 How to Cite?
AbstractThe effects of adenosine, ATP and adenosine β, γ-methylene-5'-triphosphate (APPCP) were compared in the saphenous vein of the dog. Adenosine and ATP in concentrations which did not affect the response to exogenous noradrenaline, depressed that to nerve stimulation; this effect was antagonized by theophylline. APPCP increased tension in unstimulated veins and in those made to contract with noradrenaline and nerve stimulation. The results suggest that the inhibitory effect of ATP on adrenergic neurotransmission is due to its rapid breakdown to adenosine, which acts on prejunctional P1 purinoceptors.
Persistent Identifierhttp://hdl.handle.net/10722/170582
ISSN
0014-2999
2021 Impact Factor: 5.195
2020 SCImago Journal Rankings: 1.046
ISI Accession Number ID
WOS:A1979GX84700008

 

DC FieldValueLanguage
dc.contributor.authorDe Mey, Jen_US
dc.contributor.authorBurnstock, Gen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:02Z-
dc.date.available2012-10-30T06:10:02Z-
dc.date.issued1979en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1979, v. 55 n. 4, p. 401-405en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170582-
dc.description.abstractThe effects of adenosine, ATP and adenosine β, γ-methylene-5'-triphosphate (APPCP) were compared in the saphenous vein of the dog. Adenosine and ATP in concentrations which did not affect the response to exogenous noradrenaline, depressed that to nerve stimulation; this effect was antagonized by theophylline. APPCP increased tension in unstimulated veins and in those made to contract with noradrenaline and nerve stimulation. The results suggest that the inhibitory effect of ATP on adrenergic neurotransmission is due to its rapid breakdown to adenosine, which acts on prejunctional P1 purinoceptors.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subjectAdenosine-
dc.subjectAdenosine β, γ-methylene-5′-triphosphate-
dc.subjectAdenosine-5′-triphosphate-
dc.subjectAdrenergic neurotransmission-
dc.subjectSaphenous vein Purinergic receptors-
dc.subject.meshAdenosine - Physiologyen_US
dc.subject.meshAdenosine Triphosphate - Analogs & Derivatives - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Vessels - Metabolismen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscle, Smooth - Physiologyen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshReceptors, Cell Surface - Physiologyen_US
dc.subject.meshSaphenous Vein - Metabolismen_US
dc.titleModulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATPen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid223855-
dc.identifier.scopuseid_2-s2.0-0018392008en_US
dc.identifier.volume55en_US
dc.identifier.issue4en_US
dc.identifier.spage401en_US
dc.identifier.epage405en_US
dc.identifier.isiWOS:A1979GX84700008-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridDe Mey, J=7101918486en_US
dc.identifier.scopusauthoridBurnstock, G=36037094600en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0014-2999-

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