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- Publisher Website: 10.1016/0014-2999(84)90432-1
- Scopus: eid_2-s2.0-0021355607
- PMID: 6426981
- WOS: WOS:A1984SL25400008
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Article: The interaction of cycle length with the electrophysiological effect of lidocaine, tocainide and verapamil on canine Purkinje fibers
Title | The interaction of cycle length with the electrophysiological effect of lidocaine, tocainide and verapamil on canine Purkinje fibers |
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Authors | |
Keywords | Cycle length Electrophysiological effect Lidocaine Tocainide Verapamil |
Issue Date | 1984 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1984, v. 99 n. 1, p. 63-71 How to Cite? |
Abstract | Intracellular action potentials were recorded from normal canine Purkinje fibers using the standard microelectrode technique. The effects of lidocaine (2 and 5 mg/l), tocainide (10 and 20 mg/l) and verapamil (0.5 and 1.0 mg/l) on action potential characteristics as well as conduction times were measured at cycle lengths of 1000, 800, 600, 500, 400 and 300 ms. Lidocaine and tocainide shortened APD(50%) and APD(90%), and verapamil shortened APD(50%) and lengthened APD(90%). All of these effects were greatest at the longest cycle lengths. A similar interaction of changes in ERP with cycle length was observed for lidocaine and tocainide. Verapamil increased ERP but this effect was not significant. Tocainide and verapamil reduced dV/dt(max) while lidocaine had no significant effect. All three drugs dv/dt(max) and conduction times were observed. These results indicate that many of the electrophysiological effects of lidocaine, tocainide and verapamil are modified by cycle length. We propose that future studies on the electrophysiology of antiarrhythmic drugs should include stimulation both at long and short cycle lengths. |
Persistent Identifier | http://hdl.handle.net/10722/170744 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kinnaird, AAA | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:10:40Z | - |
dc.date.available | 2012-10-30T06:10:40Z | - |
dc.date.issued | 1984 | en_US |
dc.identifier.citation | European Journal Of Pharmacology, 1984, v. 99 n. 1, p. 63-71 | en_US |
dc.identifier.issn | 0014-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170744 | - |
dc.description.abstract | Intracellular action potentials were recorded from normal canine Purkinje fibers using the standard microelectrode technique. The effects of lidocaine (2 and 5 mg/l), tocainide (10 and 20 mg/l) and verapamil (0.5 and 1.0 mg/l) on action potential characteristics as well as conduction times were measured at cycle lengths of 1000, 800, 600, 500, 400 and 300 ms. Lidocaine and tocainide shortened APD(50%) and APD(90%), and verapamil shortened APD(50%) and lengthened APD(90%). All of these effects were greatest at the longest cycle lengths. A similar interaction of changes in ERP with cycle length was observed for lidocaine and tocainide. Verapamil increased ERP but this effect was not significant. Tocainide and verapamil reduced dV/dt(max) while lidocaine had no significant effect. All three drugs dv/dt(max) and conduction times were observed. These results indicate that many of the electrophysiological effects of lidocaine, tocainide and verapamil are modified by cycle length. We propose that future studies on the electrophysiology of antiarrhythmic drugs should include stimulation both at long and short cycle lengths. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject | Cycle length | - |
dc.subject | Electrophysiological effect | - |
dc.subject | Lidocaine | - |
dc.subject | Tocainide | - |
dc.subject | Verapamil | - |
dc.subject.mesh | Action Potentials - Drug Effects | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anti-Arrhythmia Agents - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Electrophysiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Heart Conduction System - Drug Effects | en_US |
dc.subject.mesh | Lidocaine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Purkinje Fibers - Drug Effects - Physiology | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.subject.mesh | Tocainide | en_US |
dc.subject.mesh | Verapamil - Pharmacology | en_US |
dc.title | The interaction of cycle length with the electrophysiological effect of lidocaine, tocainide and verapamil on canine Purkinje fibers | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-2999(84)90432-1 | en_US |
dc.identifier.pmid | 6426981 | - |
dc.identifier.scopus | eid_2-s2.0-0021355607 | en_US |
dc.identifier.volume | 99 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 63 | en_US |
dc.identifier.epage | 71 | en_US |
dc.identifier.isi | WOS:A1984SL25400008 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Kinnaird, AAA=6603472891 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0014-2999 | - |