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- Publisher Website: 10.1097/00005344-198500073-00002
- Scopus: eid_2-s2.0-0022260704
- PMID: 2409385
- WOS: WOS:A1985AMJ2900002
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Article: Heterogeneity of endothelium-dependent responses in mammalian blood vessels
Title | Heterogeneity of endothelium-dependent responses in mammalian blood vessels |
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Authors | |
Keywords | Acetylcholine Adenosine nucleotides Aggregating platelets Arachidonic acid Arteries Endothelium Serotonin Thrombin Vascular smooth muscle Veins |
Issue Date | 1985 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 3, p. S12-S23 How to Cite? |
Abstract | A number of naturally occurring substances can evoke endothelium-dependent responses in isolated blood vessels. In most arteries studied, acetylcholine, adenosine diphosphate (ADP), adenosine triphosphate (ATP), arachidonic acid, bradykinin, and thrombin cause endothelium-dependent relaxations. In veins, however, the endothelium-dependent inhibitory effect of acetylcholine, ATP, and thrombin often is transient and/or modest, as it is masked by the direct stimulating action of these substances on the venous smooth muscle; arachidonic acid evokes endothelium-dependent augmentation of the contractile response to norepinephrine. Aggregating platelets cause an endothelium-dependent relaxation of certain but not all arteries and veins that is probably mediated by released serotonin and ADP. The endothelium of the coronary artery may enhance the relaxations caused by catecholamines. Vasopressin causes endothelium-dependent relaxations in cerebral and coronary arteries but not in systemic blood vessels. Hypoxia causes endothelium-dependent increases in tension in systemic arteries and in pulmonary arteries and veins but not in limb veins. The heterogeneity in endothelium-dependent responsiveness may reflect variations in sensitivity of either endothelial or vascular smooth-muscle cells of different anatomical origin. |
Persistent Identifier | http://hdl.handle.net/10722/170791 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Miller, VM | en_US |
dc.date.accessioned | 2012-10-30T06:10:52Z | - |
dc.date.available | 2012-10-30T06:10:52Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 3, p. S12-S23 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170791 | - |
dc.description.abstract | A number of naturally occurring substances can evoke endothelium-dependent responses in isolated blood vessels. In most arteries studied, acetylcholine, adenosine diphosphate (ADP), adenosine triphosphate (ATP), arachidonic acid, bradykinin, and thrombin cause endothelium-dependent relaxations. In veins, however, the endothelium-dependent inhibitory effect of acetylcholine, ATP, and thrombin often is transient and/or modest, as it is masked by the direct stimulating action of these substances on the venous smooth muscle; arachidonic acid evokes endothelium-dependent augmentation of the contractile response to norepinephrine. Aggregating platelets cause an endothelium-dependent relaxation of certain but not all arteries and veins that is probably mediated by released serotonin and ADP. The endothelium of the coronary artery may enhance the relaxations caused by catecholamines. Vasopressin causes endothelium-dependent relaxations in cerebral and coronary arteries but not in systemic blood vessels. Hypoxia causes endothelium-dependent increases in tension in systemic arteries and in pulmonary arteries and veins but not in limb veins. The heterogeneity in endothelium-dependent responsiveness may reflect variations in sensitivity of either endothelial or vascular smooth-muscle cells of different anatomical origin. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject | Acetylcholine | - |
dc.subject | Adenosine nucleotides | - |
dc.subject | Aggregating platelets | - |
dc.subject | Arachidonic acid | - |
dc.subject | Arteries | - |
dc.subject | Endothelium | - |
dc.subject | Serotonin | - |
dc.subject | Thrombin | - |
dc.subject | Vascular smooth muscle | - |
dc.subject | Veins | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anoxia - Physiopathology | en_US |
dc.subject.mesh | Arachidonic Acid | en_US |
dc.subject.mesh | Arachidonic Acids - Pharmacology | en_US |
dc.subject.mesh | Blood Vessels - Drug Effects - Physiology | en_US |
dc.subject.mesh | Bradykinin - Pharmacology | en_US |
dc.subject.mesh | Catecholamines - Pharmacology | en_US |
dc.subject.mesh | Endothelium - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Thrombin - Pharmacology | en_US |
dc.subject.mesh | Vasopressins - Pharmacology | en_US |
dc.title | Heterogeneity of endothelium-dependent responses in mammalian blood vessels | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00005344-198500073-00002 | - |
dc.identifier.pmid | 2409385 | - |
dc.identifier.scopus | eid_2-s2.0-0022260704 | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | SUPPL. 3 | en_US |
dc.identifier.spage | S12 | en_US |
dc.identifier.epage | S23 | en_US |
dc.identifier.isi | WOS:A1985AMJ2900002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Miller, VM=7201476816 | en_US |
dc.identifier.issnl | 0160-2446 | - |