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- Publisher Website: 10.1016/0014-2999(88)90441-4
- Scopus: eid_2-s2.0-0023840537
- PMID: 3258243
- WOS: WOS:A1988L828500016
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Article: Potassium-free solution prevents the action but not the release of endothelium-derived relaxing factor
Title | Potassium-free solution prevents the action but not the release of endothelium-derived relaxing factor |
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Authors | |
Keywords | Acetylcholine Endothelium-derived relaxing factor Femoral artery Na+,K+ pump Smooth muscle (vascular) |
Issue Date | 1988 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1988, v. 145 n. 3, p. 351-355 How to Cite? |
Abstract | Exposure to a K+-free solution reversibly inhibited the acetylcholine-induced relaxation in perfused canine femoral artery segments with endothelium and in superfused bioassay femoral artery rings without endothelium. Infusion of 6.7 mM K+ into the K+-free perfusate downstream of the perfused artery restored the acetylcholine-induced relaxation in the bioassay ring, whereas no relaxation was observed in the perfused segment still exposed to the K+-free solution. These data demonstrate that the K+-free solution depresses the endothelium-dependent relaxation to acetylcholine in femoral arteries by preventing the action, but not the production, of endothelium-derived relaxing factor. |
Persistent Identifier | http://hdl.handle.net/10722/170887 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rubanyi, GM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:17Z | - |
dc.date.available | 2012-10-30T06:11:17Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | European Journal Of Pharmacology, 1988, v. 145 n. 3, p. 351-355 | en_US |
dc.identifier.issn | 0014-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170887 | - |
dc.description.abstract | Exposure to a K+-free solution reversibly inhibited the acetylcholine-induced relaxation in perfused canine femoral artery segments with endothelium and in superfused bioassay femoral artery rings without endothelium. Infusion of 6.7 mM K+ into the K+-free perfusate downstream of the perfused artery restored the acetylcholine-induced relaxation in the bioassay ring, whereas no relaxation was observed in the perfused segment still exposed to the K+-free solution. These data demonstrate that the K+-free solution depresses the endothelium-dependent relaxation to acetylcholine in femoral arteries by preventing the action, but not the production, of endothelium-derived relaxing factor. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject | Acetylcholine | - |
dc.subject | Endothelium-derived relaxing factor | - |
dc.subject | Femoral artery | - |
dc.subject | Na+,K+ pump | - |
dc.subject | Smooth muscle (vascular) | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Agents - Biosynthesis - Pharmacology | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Femoral Artery - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Relaxation - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects | en_US |
dc.subject.mesh | Nitric Oxide | en_US |
dc.subject.mesh | Perfusion | en_US |
dc.subject.mesh | Potassium - Metabolism | en_US |
dc.subject.mesh | Prostaglandins F - Pharmacology | en_US |
dc.subject.mesh | Vasodilator Agents - Biosynthesis - Pharmacology | en_US |
dc.title | Potassium-free solution prevents the action but not the release of endothelium-derived relaxing factor | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-2999(88)90441-4 | en_US |
dc.identifier.pmid | 3258243 | en_US |
dc.identifier.scopus | eid_2-s2.0-0023840537 | en_US |
dc.identifier.volume | 145 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 351 | en_US |
dc.identifier.epage | 355 | en_US |
dc.identifier.isi | WOS:A1988L828500016 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Rubanyi, GM=7005517991 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0014-2999 | - |