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- Publisher Website: 10.1016/0091-3057(89)90388-2
- Scopus: eid_2-s2.0-0024420264
- PMID: 2555822
- WOS: WOS:A1989AQ70000013
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Article: Does acidosis contribute to stress-induced ulceration in rat stomachs?
Title | Does acidosis contribute to stress-induced ulceration in rat stomachs? |
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Authors | |
Keywords | Acidosis Cold-restraint stress Gastric ulcers HCl NaHCO3 |
Issue Date | 1989 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh |
Citation | Pharmacology Biochemistry And Behavior, 1989, v. 33 n. 3, p. 563-566 How to Cite? |
Abstract | The present study examines the involvement of acidosis in stress ulceration in rat stomachs. Cold restraint stress for 2 hr did not affect the blood lactate level; however, it produced respiratory acidosis, as reflected by the depressed respiratory rate which was associated with increased CO2 tension and a lowered blood pH. Severe hemorrhagic ulceration was found in the glandular mucosa. The effects of stress on blood pH and the stomach were reversed by IV infusion of NaHCO3. Infusion of HCl IV decreased the blood pH and HCO3 - level and produced gastric ulceration. It is concluded that respiratory acidosis could be involved in stress ulceration. The metabolic acidosis evoked by HCl also induced gastric damage, but the effect was much less. |
Persistent Identifier | http://hdl.handle.net/10722/170934 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.050 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Koo, MWL | en_US |
dc.contributor.author | Cho, CH | en_US |
dc.contributor.author | Ogle, CW | en_US |
dc.date.accessioned | 2012-10-30T06:11:29Z | - |
dc.date.available | 2012-10-30T06:11:29Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Pharmacology Biochemistry And Behavior, 1989, v. 33 n. 3, p. 563-566 | en_US |
dc.identifier.issn | 0091-3057 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170934 | - |
dc.description.abstract | The present study examines the involvement of acidosis in stress ulceration in rat stomachs. Cold restraint stress for 2 hr did not affect the blood lactate level; however, it produced respiratory acidosis, as reflected by the depressed respiratory rate which was associated with increased CO2 tension and a lowered blood pH. Severe hemorrhagic ulceration was found in the glandular mucosa. The effects of stress on blood pH and the stomach were reversed by IV infusion of NaHCO3. Infusion of HCl IV decreased the blood pH and HCO3 - level and produced gastric ulceration. It is concluded that respiratory acidosis could be involved in stress ulceration. The metabolic acidosis evoked by HCl also induced gastric damage, but the effect was much less. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh | en_US |
dc.relation.ispartof | Pharmacology Biochemistry and Behavior | en_US |
dc.subject | Acidosis | - |
dc.subject | Cold-restraint stress | - |
dc.subject | Gastric ulcers | - |
dc.subject | HCl | - |
dc.subject | NaHCO3 | - |
dc.subject.mesh | Acidosis, Respiratory - Complications - Physiopathology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bicarbonates - Blood - Pharmacology | en_US |
dc.subject.mesh | Carbon Dioxide - Blood | en_US |
dc.subject.mesh | Cold Temperature - Adverse Effects | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hydrochloric Acid - Adverse Effects - Pharmacology | en_US |
dc.subject.mesh | Hydrogen-Ion Concentration | en_US |
dc.subject.mesh | Lactates - Blood | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Restraint, Physical | en_US |
dc.subject.mesh | Sodium - Pharmacology | en_US |
dc.subject.mesh | Sodium Bicarbonate | en_US |
dc.subject.mesh | Stomach Ulcer - Etiology | en_US |
dc.subject.mesh | Stress, Physiological - Blood - Complications - Physiopathology | en_US |
dc.title | Does acidosis contribute to stress-induced ulceration in rat stomachs? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Koo, MWL:wlkoo@hku.hk | en_US |
dc.identifier.authority | Koo, MWL=rp00233 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0091-3057(89)90388-2 | - |
dc.identifier.pmid | 2555822 | - |
dc.identifier.scopus | eid_2-s2.0-0024420264 | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 563 | en_US |
dc.identifier.epage | 566 | en_US |
dc.identifier.isi | WOS:A1989AQ70000013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Koo, MWL=7004550899 | en_US |
dc.identifier.scopusauthorid | Cho, CH=7403100461 | en_US |
dc.identifier.scopusauthorid | Ogle, CW=7103150233 | en_US |
dc.identifier.issnl | 0091-3057 | - |