File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/0002-9343(89)90496-8
- Scopus: eid_2-s2.0-0024443813
- PMID: 2551167
- WOS: WOS:A1989AT66300001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Alpha2-adrenoceptors and endothelium-derived relaxing factor
Title | Alpha2-adrenoceptors and endothelium-derived relaxing factor |
---|---|
Authors | |
Issue Date | 1989 |
Publisher | Excerpta Medica, Inc. The Journal's web site is located at http://www.elsevier.com/locate/amj |
Citation | American Journal Of Medicine, 1989, v. 87 n. 3 C, p. 1S-5S How to Cite? |
Abstract | The endothelium can release potent vasodilator substances, in particular prostacyclin and endothelium-derived relaxing factor. The triggers for the release of endothelium-derived relaxing factor include increases in levels of shear stress, neurotransmitters, autacoids, platelet products, and hormones. The endothelium-dependent response to catecholamines involves stimulation of alpha2-adrenoceptors on the endothelial cells. Indeed, in a number of blood vessels, selective alpha2-adrenergic agonists cause endothelium-dependent relaxations. These are seen most typically in blood vessels with long-term exposure to high flows and high partial pressures of oxygen. In addition to the release of endothelium-derived relaxing factor, alpha2-adrenergic agonists can stimulate postjunctional (postsynaptic) alpha2-adrenoceptors on vascular smooth muscles. These receptors, which are more abundant in hypertensive blood vessels, activate the contractile process. However, the alpha2-adrenergic vasoconstrictors act as partial agonists (with a limited receptor reserve) and hence their vasoconstrictor response is very sensitive to functional antagonists such as endothelium-derived relaxing factor. Thus, the presence of endothelial cells can blunt the vasoconstrictor response to these substances not only because of an augmented release of endothelium-derived relaxing factor but also because the vasoconstriction that they induce is particularly susceptible to the inhibitory effect of the factor. |
Persistent Identifier | http://hdl.handle.net/10722/170938 |
ISSN | 2023 Impact Factor: 5.1 2023 SCImago Journal Rankings: 1.063 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Miller, VM | en_US |
dc.date.accessioned | 2012-10-30T06:11:30Z | - |
dc.date.available | 2012-10-30T06:11:30Z | - |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | American Journal Of Medicine, 1989, v. 87 n. 3 C, p. 1S-5S | en_US |
dc.identifier.issn | 0002-9343 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170938 | - |
dc.description.abstract | The endothelium can release potent vasodilator substances, in particular prostacyclin and endothelium-derived relaxing factor. The triggers for the release of endothelium-derived relaxing factor include increases in levels of shear stress, neurotransmitters, autacoids, platelet products, and hormones. The endothelium-dependent response to catecholamines involves stimulation of alpha2-adrenoceptors on the endothelial cells. Indeed, in a number of blood vessels, selective alpha2-adrenergic agonists cause endothelium-dependent relaxations. These are seen most typically in blood vessels with long-term exposure to high flows and high partial pressures of oxygen. In addition to the release of endothelium-derived relaxing factor, alpha2-adrenergic agonists can stimulate postjunctional (postsynaptic) alpha2-adrenoceptors on vascular smooth muscles. These receptors, which are more abundant in hypertensive blood vessels, activate the contractile process. However, the alpha2-adrenergic vasoconstrictors act as partial agonists (with a limited receptor reserve) and hence their vasoconstrictor response is very sensitive to functional antagonists such as endothelium-derived relaxing factor. Thus, the presence of endothelial cells can blunt the vasoconstrictor response to these substances not only because of an augmented release of endothelium-derived relaxing factor but also because the vasoconstriction that they induce is particularly susceptible to the inhibitory effect of the factor. | en_US |
dc.language | eng | en_US |
dc.publisher | Excerpta Medica, Inc. The Journal's web site is located at http://www.elsevier.com/locate/amj | en_US |
dc.relation.ispartof | American Journal of Medicine | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Factors - Metabolism - Physiology | en_US |
dc.subject.mesh | Catecholamines - Physiology | en_US |
dc.subject.mesh | Endothelium, Vascular - Metabolism - Physiology | en_US |
dc.subject.mesh | Nitric Oxide | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Physiology | en_US |
dc.subject.mesh | Vasodilation | en_US |
dc.title | Alpha2-adrenoceptors and endothelium-derived relaxing factor | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0002-9343(89)90496-8 | - |
dc.identifier.pmid | 2551167 | - |
dc.identifier.scopus | eid_2-s2.0-0024443813 | en_US |
dc.identifier.volume | 87 | en_US |
dc.identifier.issue | 3 C | en_US |
dc.identifier.spage | 1S | en_US |
dc.identifier.epage | 5S | en_US |
dc.identifier.isi | WOS:A1989AT66300001 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Miller, VM=7201476816 | en_US |
dc.identifier.issnl | 0002-9343 | - |