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Article: Epithelial modulation of airway smooth muscle

TitleEpithelial modulation of airway smooth muscle
Authors
Morrison, KJGao, YVanhoutte, PM
Keywordsepithelium
epithelium-derived relaxing factors
Issue Date1990
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Lung Cellular And Molecular Physiology, 1990, v. 258 n. 6 2-3, p. L254-L262 How to Cite?
AbstractThe responsiveness of airway smooth muscle is influenced by the functional integrity of the respiratory epithelium. The nature of this regulatory action by the epithelium remains largely unresolved. Several explanations may account for the epithelium-dependent responses induced by numerous stimuli. This review will present and discuss the evidence suggesting that the epithelium generates an inhibitory signal or signals that function to modulate the responsiveness of the underlying smooth muscle. In addition, the possible candidates for the identity of this epithelium-derived relaxing factor or factors will be assessed. Finally, the mechanisms by which the epithelium-derived relaxing factors may act to modulate bronchomotor tone will be discussed.
Persistent Identifierhttp://hdl.handle.net/10722/170988
ISSN
0002-9513
ISI Accession Number ID
WOS:A1990DL73100075

 

DC FieldValueLanguage
dc.contributor.authorMorrison, KJen_US
dc.contributor.authorGao, Yen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:44Z-
dc.date.available2012-10-30T06:11:44Z-
dc.date.issued1990en_US
dc.identifier.citationAmerican Journal Of Physiology - Lung Cellular And Molecular Physiology, 1990, v. 258 n. 6 2-3, p. L254-L262en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170988-
dc.description.abstractThe responsiveness of airway smooth muscle is influenced by the functional integrity of the respiratory epithelium. The nature of this regulatory action by the epithelium remains largely unresolved. Several explanations may account for the epithelium-dependent responses induced by numerous stimuli. This review will present and discuss the evidence suggesting that the epithelium generates an inhibitory signal or signals that function to modulate the responsiveness of the underlying smooth muscle. In addition, the possible candidates for the identity of this epithelium-derived relaxing factor or factors will be assessed. Finally, the mechanisms by which the epithelium-derived relaxing factors may act to modulate bronchomotor tone will be discussed.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Lung Cellular and Molecular Physiologyen_US
dc.subjectepithelium-
dc.subjectepithelium-derived relaxing factors-
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Physiologyen_US
dc.subject.meshEpithelium - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle, Smooth - Physiologyen_US
dc.subject.meshRespiratory Physiological Phenomenaen_US
dc.titleEpithelial modulation of airway smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2193539-
dc.identifier.scopuseid_2-s2.0-0025310613en_US
dc.identifier.volume258en_US
dc.identifier.issue6 2-3en_US
dc.identifier.spageL254en_US
dc.identifier.epageL262en_US
dc.identifier.isiWOS:A1990DL73100075-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMorrison, KJ=7102484828en_US
dc.identifier.scopusauthoridGao, Y=7404706442en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0002-9513-

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