File Download
There are no files associated with this item.
Supplementary
- Citations:
- Appears in Collections:
Article: 17β-Estradiol augments endothelium-dependent contractions to arachidonic acid in rabbit aorta
Title | 17β-Estradiol augments endothelium-dependent contractions to arachidonic acid in rabbit aorta |
---|---|
Authors | |
Keywords | acetylcholine adrenergic calcium ionophore estrogen hormones norepinephrine prostacyclin |
Issue Date | 1990 |
Publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ |
Citation | American Journal Of Physiology - Regulatory Integrative And Comparative Physiology, 1990, v. 258 n. 6 27-6, p. R1502-R1507 How to Cite? |
Abstract | Experiments were designed to determine the effects of chronic estrogen treatment on endothelium-dependent responses to arachidonic acid in the aorta of the rabbit. Ovariectomized rabbits were treated with either placebo or 17β-estradiol for 14 days. The aortas were removed, and rings cut from each blood vessel were suspended for measurement of isometric force. In rings contracted with a submaximal concentration of norepinephrine, endothelium-dependent contractions to arachidonic acid were augmented by estrogen treatment. Prostaglandin F(2α), E2, the thromboxane analogue U 46619, and prostacyclin contracted aortic smooth muscle. Only the contractions to prostacyclin were augmented by estrogen treatment. Estrogen treatment enhanced the contractions to norepinephrine in aortas with, but not in those without, endothelium; these contractions were not affected by inhibition of uptake of the neurotransmitter. Indomethacin inhibited contractions to norepinephrine in rings with endothelium from estrogen-treated rabbits. These results indicate that chronic treatment with estrogens can affect arterial reactivity to norepinephrine through an endothelium-dependent mechanism that may involve the metabolism of arachidonic acid by cyclooxygenase. The altered sensitivity of the smooth muscle to prostacyclin may contribute in part to the augmented contractions to arachidonic acid with estrogen treatment. |
Persistent Identifier | http://hdl.handle.net/10722/170990 |
ISSN |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Miller, VM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:44Z | - |
dc.date.available | 2012-10-30T06:11:44Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | American Journal Of Physiology - Regulatory Integrative And Comparative Physiology, 1990, v. 258 n. 6 27-6, p. R1502-R1507 | en_US |
dc.identifier.issn | 0002-9513 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170990 | - |
dc.description.abstract | Experiments were designed to determine the effects of chronic estrogen treatment on endothelium-dependent responses to arachidonic acid in the aorta of the rabbit. Ovariectomized rabbits were treated with either placebo or 17β-estradiol for 14 days. The aortas were removed, and rings cut from each blood vessel were suspended for measurement of isometric force. In rings contracted with a submaximal concentration of norepinephrine, endothelium-dependent contractions to arachidonic acid were augmented by estrogen treatment. Prostaglandin F(2α), E2, the thromboxane analogue U 46619, and prostacyclin contracted aortic smooth muscle. Only the contractions to prostacyclin were augmented by estrogen treatment. Estrogen treatment enhanced the contractions to norepinephrine in aortas with, but not in those without, endothelium; these contractions were not affected by inhibition of uptake of the neurotransmitter. Indomethacin inhibited contractions to norepinephrine in rings with endothelium from estrogen-treated rabbits. These results indicate that chronic treatment with estrogens can affect arterial reactivity to norepinephrine through an endothelium-dependent mechanism that may involve the metabolism of arachidonic acid by cyclooxygenase. The altered sensitivity of the smooth muscle to prostacyclin may contribute in part to the augmented contractions to arachidonic acid with estrogen treatment. | en_US |
dc.language | eng | en_US |
dc.publisher | American Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/ | en_US |
dc.relation.ispartof | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | en_US |
dc.subject | acetylcholine | - |
dc.subject | adrenergic | - |
dc.subject | calcium ionophore | - |
dc.subject | estrogen | - |
dc.subject | hormones | - |
dc.subject | norepinephrine | - |
dc.subject | prostacyclin | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aorta - Drug Effects | en_US |
dc.subject.mesh | Arachidonic Acid | en_US |
dc.subject.mesh | Arachidonic Acids - Pharmacology | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology | en_US |
dc.subject.mesh | Estradiol - Blood - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Prostaglandins - Pharmacology | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Vasoconstriction | en_US |
dc.title | 17β-Estradiol augments endothelium-dependent contractions to arachidonic acid in rabbit aorta | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 2113777 | - |
dc.identifier.scopus | eid_2-s2.0-0025326705 | en_US |
dc.identifier.volume | 258 | en_US |
dc.identifier.issue | 6 27-6 | en_US |
dc.identifier.spage | R1502 | en_US |
dc.identifier.epage | R1507 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Miller, VM=7201476816 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0002-9513 | - |