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Article: Evidences for the existence of endothelium-derived relaxing factor in the renal medulla

TitleEvidences for the existence of endothelium-derived relaxing factor in the renal medulla
Authors
Biondi, MLDousa, TVanhoutte, PRomero, JC
KeywordsCGMP, acetylcholine
Endothelium-derived relaxing factor
Renal medulla
Issue Date1990
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyper
Citation
American Journal Of Hypertension, 1990, v. 3 n. 11, p. 876-878 How to Cite?
DOI: http://dx.doi.org/10.1093/ajh/3.11.876
AbstractThe basal levels of cGMP in renal medulla slices were enhanced when the slices were stimulated with both endothelium-dependent (acetylcholine) and endothelium-independent (molsidomine) vasodilators. When preincubated with N(G)-monomethyl-L-arginine, a specific inhibitor of endothelium-derived relaxing factor, only the acetylcholine-stimulated increase was completely abolished. Furthermore, a preincubation with L-arginine, a selective precursor of endothelium-derived relaxing factor, enhanced the cGMP levels. The results indicate that the renal medulla, presumably the endothelial cells of the vasa recta, is able to produce endothelium-derived relaxing factor.
Persistent Identifierhttp://hdl.handle.net/10722/170996
ISSN
0895-7061
2021 Impact Factor: 3.080
2020 SCImago Journal Rankings: 1.009
ISI Accession Number ID
WOS:A1990EJ79700012

 

DC FieldValueLanguage
dc.contributor.authorBiondi, MLen_US
dc.contributor.authorDousa, Ten_US
dc.contributor.authorVanhoutte, Pen_US
dc.contributor.authorRomero, JCen_US
dc.date.accessioned2012-10-30T06:11:46Z-
dc.date.available2012-10-30T06:11:46Z-
dc.date.issued1990en_US
dc.identifier.citationAmerican Journal Of Hypertension, 1990, v. 3 n. 11, p. 876-878en_US
dc.identifier.issn0895-7061en_US
dc.identifier.urihttp://hdl.handle.net/10722/170996-
dc.description.abstractThe basal levels of cGMP in renal medulla slices were enhanced when the slices were stimulated with both endothelium-dependent (acetylcholine) and endothelium-independent (molsidomine) vasodilators. When preincubated with N(G)-monomethyl-L-arginine, a specific inhibitor of endothelium-derived relaxing factor, only the acetylcholine-stimulated increase was completely abolished. Furthermore, a preincubation with L-arginine, a selective precursor of endothelium-derived relaxing factor, enhanced the cGMP levels. The results indicate that the renal medulla, presumably the endothelial cells of the vasa recta, is able to produce endothelium-derived relaxing factor.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyperen_US
dc.relation.ispartofAmerican Journal of Hypertensionen_US
dc.subjectCGMP, acetylcholine-
dc.subjectEndothelium-derived relaxing factor-
dc.subjectRenal medulla-
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshCyclic Gmp - Analysis - Metabolismen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshKidney Medulla - Chemistry - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMolsidomine - Pharmacologyen_US
dc.subject.meshNitric Oxide - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshPremedicationen_US
dc.subject.meshOmega-N-Methylarginineen_US
dc.titleEvidences for the existence of endothelium-derived relaxing factor in the renal medullaen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, P:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, P=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/ajh/3.11.876-
dc.identifier.pmid2175626-
dc.identifier.scopuseid_2-s2.0-0025611631en_US
dc.identifier.volume3en_US
dc.identifier.issue11en_US
dc.identifier.spage876en_US
dc.identifier.epage878en_US
dc.identifier.isiWOS:A1990EJ79700012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBiondi, ML=7005127265en_US
dc.identifier.scopusauthoridDousa, T=35510540700en_US
dc.identifier.scopusauthoridVanhoutte, P=7202304247en_US
dc.identifier.scopusauthoridRomero, JC=7402018868en_US
dc.identifier.issnl0895-7061-

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