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- Publisher Website: 10.1161/01.STR.23.3.407
- Scopus: eid_2-s2.0-0026585013
- PMID: 1542904
- WOS: WOS:A1992HH21900016
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Article: Dietary ω-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries
Title | Dietary ω-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries |
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Authors | |
Keywords | Basilar artery Endothelium-derived relaxing factor Fatty acids, unsaturated Pigs |
Issue Date | 1992 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org |
Citation | Stroke, 1992, v. 23 n. 3, p. 407-413 How to Cite? |
Abstract | Purpose: We sought to determine the effect of dietary ω-3 polyunsaturated fatty acids on cerebrovascular endothelium-dependent responses in studies performed on isolated porcine basilar arteries. Methods: Male Yorkshire pigs (6-8 weeks old) were kept for 4 weeks on a standard diet (control group, n=12) or on chow supplemented with polyunsaturated fatty acids (eicosapentaenoic acid, 3.5 g/day, or docosahexaenoic acid, 1.5 g/day; treated group, n=12). Isometric tension recording of the basilar artery was carried out and responses were compared between the two groups. Results: The regimen resulted in a decrease in the plasma arachidonic acid level and an increase in eicosapentaenoic acid. Endothelium-dependent relaxations induced by bradykinin and adenosine diphosphate were augmented in the basilar arteries of the treated group. Incubation with indomethacin (10-5 M) prevented the augmentation of the relaxations induced by bradykinin, but not those caused by adenosine diphosphate. The indomethacin-sensitive, endothelium-dependent contractions to arachidonic acid remained comparable in the two groups, indicating that the activity of cyclooxygenase was not affected by the diet. Conclusions: Dietary supplementation with ω-3 polyunsaturated fatty acids enhances endothelium-dependent relaxations in the basilar artery by two mechanisms: 1) replacement of endogenous arachidonic acid and suppression of the concomitant release of vasoconstrictor prostaglandins from the endothelium, and 2) enhancement of the release of endothelium-derived relaxing factor. |
Persistent Identifier | http://hdl.handle.net/10722/171054 |
ISSN | 2023 Impact Factor: 7.8 2023 SCImago Journal Rankings: 2.450 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kim, P | en_US |
dc.contributor.author | Shimokawa, H | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:00Z | - |
dc.date.available | 2012-10-30T06:12:00Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Stroke, 1992, v. 23 n. 3, p. 407-413 | en_US |
dc.identifier.issn | 0039-2499 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171054 | - |
dc.description.abstract | Purpose: We sought to determine the effect of dietary ω-3 polyunsaturated fatty acids on cerebrovascular endothelium-dependent responses in studies performed on isolated porcine basilar arteries. Methods: Male Yorkshire pigs (6-8 weeks old) were kept for 4 weeks on a standard diet (control group, n=12) or on chow supplemented with polyunsaturated fatty acids (eicosapentaenoic acid, 3.5 g/day, or docosahexaenoic acid, 1.5 g/day; treated group, n=12). Isometric tension recording of the basilar artery was carried out and responses were compared between the two groups. Results: The regimen resulted in a decrease in the plasma arachidonic acid level and an increase in eicosapentaenoic acid. Endothelium-dependent relaxations induced by bradykinin and adenosine diphosphate were augmented in the basilar arteries of the treated group. Incubation with indomethacin (10-5 M) prevented the augmentation of the relaxations induced by bradykinin, but not those caused by adenosine diphosphate. The indomethacin-sensitive, endothelium-dependent contractions to arachidonic acid remained comparable in the two groups, indicating that the activity of cyclooxygenase was not affected by the diet. Conclusions: Dietary supplementation with ω-3 polyunsaturated fatty acids enhances endothelium-dependent relaxations in the basilar artery by two mechanisms: 1) replacement of endogenous arachidonic acid and suppression of the concomitant release of vasoconstrictor prostaglandins from the endothelium, and 2) enhancement of the release of endothelium-derived relaxing factor. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org | en_US |
dc.relation.ispartof | Stroke | en_US |
dc.subject | Basilar artery | - |
dc.subject | Endothelium-derived relaxing factor | - |
dc.subject | Fatty acids, unsaturated | - |
dc.subject | Pigs | - |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Basilar Artery - Drug Effects - Physiology | en_US |
dc.subject.mesh | Bradykinin - Pharmacology | en_US |
dc.subject.mesh | Dietary Fats - Pharmacology | en_US |
dc.subject.mesh | Endothelium, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Fatty Acids, Omega-3 - Pharmacology | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Potassium Chloride - Pharmacology | en_US |
dc.subject.mesh | Swine | en_US |
dc.subject.mesh | Vasoconstriction | en_US |
dc.title | Dietary ω-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.STR.23.3.407 | - |
dc.identifier.pmid | 1542904 | - |
dc.identifier.scopus | eid_2-s2.0-0026585013 | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 407 | en_US |
dc.identifier.epage | 413 | en_US |
dc.identifier.isi | WOS:A1992HH21900016 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Kim, P=7402334666 | en_US |
dc.identifier.scopusauthorid | Shimokawa, H=16684837100 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0039-2499 | - |