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- Publisher Website: 10.1161/01.RES.70.2.248
- Scopus: eid_2-s2.0-0026586194
- PMID: 1310445
- WOS: WOS:A1992HC55400005
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Article: Reduced production of cGMP underlies the loss of endothelium-dependent relaxations in the canine basilar artery after subarachnoid hemorrhage
Title | Reduced production of cGMP underlies the loss of endothelium-dependent relaxations in the canine basilar artery after subarachnoid hemorrhage |
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Authors | |
Keywords | Basilar artery cGMP Endothelium Nitric oxide Subarachnoid hemorrhage |
Issue Date | 1992 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org |
Citation | Circulation Research, 1992, v. 70 n. 2, p. 248-256 How to Cite? |
Abstract | Endothelium-dependent relaxations are inhibited during chronic vasospasm after subarachnoid hemorrhage in the canine basilar artery, although the luminal release of endothelium-derived relaxing factor (EDRF) is maintained. The present study investigated the mechanisms underlying the impaired vascular reactivity and in particular whether the loss of responsiveness of the smooth muscle to EDRF is due to an impaired production of cGMP. Bradykinin and nitric oxide evoked concentration-dependent relaxations in isolated canine basilar arteries with and without endothelium, respectively, which were reduced in the subarachnoid hemorrhage group. Relaxations evoked by M and B22,948 (an inhibitor of cGMP phosphodiesterases) were smaller, but those evoked by the lipophilic cGMP analogue 8-bromo-cGMP were potentiated slightly in the subarachnoid hemorrhage group. The resting levels of cGMP in rings with endothelium (reflecting the effect of spontaneous release of EDRF) and those evoked by bradykinin in rings with endothelium and by nitric oxide in rings without endothelium were diminished in the subarachnoid hemorrhage group. These data indicate that the altered endothelium-mediated relaxations of the smooth muscle after subarachnoid hemorrhage is due, at least in part, to an impaired activation of soluble guanylate cyclase leading to a reduced production of cGMP in the smooth muscle. |
Persistent Identifier | http://hdl.handle.net/10722/171055 |
ISSN | 2023 Impact Factor: 16.5 2023 SCImago Journal Rankings: 4.903 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kim, P | en_US |
dc.contributor.author | Schini, VB | en_US |
dc.contributor.author | Sundt Jr, TM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:00Z | - |
dc.date.available | 2012-10-30T06:12:00Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Circulation Research, 1992, v. 70 n. 2, p. 248-256 | en_US |
dc.identifier.issn | 0009-7330 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171055 | - |
dc.description.abstract | Endothelium-dependent relaxations are inhibited during chronic vasospasm after subarachnoid hemorrhage in the canine basilar artery, although the luminal release of endothelium-derived relaxing factor (EDRF) is maintained. The present study investigated the mechanisms underlying the impaired vascular reactivity and in particular whether the loss of responsiveness of the smooth muscle to EDRF is due to an impaired production of cGMP. Bradykinin and nitric oxide evoked concentration-dependent relaxations in isolated canine basilar arteries with and without endothelium, respectively, which were reduced in the subarachnoid hemorrhage group. Relaxations evoked by M and B22,948 (an inhibitor of cGMP phosphodiesterases) were smaller, but those evoked by the lipophilic cGMP analogue 8-bromo-cGMP were potentiated slightly in the subarachnoid hemorrhage group. The resting levels of cGMP in rings with endothelium (reflecting the effect of spontaneous release of EDRF) and those evoked by bradykinin in rings with endothelium and by nitric oxide in rings without endothelium were diminished in the subarachnoid hemorrhage group. These data indicate that the altered endothelium-mediated relaxations of the smooth muscle after subarachnoid hemorrhage is due, at least in part, to an impaired activation of soluble guanylate cyclase leading to a reduced production of cGMP in the smooth muscle. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org | en_US |
dc.relation.ispartof | Circulation Research | en_US |
dc.subject | Basilar artery | - |
dc.subject | cGMP | - |
dc.subject | Endothelium | - |
dc.subject | Nitric oxide | - |
dc.subject | Subarachnoid hemorrhage | - |
dc.subject.mesh | 3',5'-Cyclic-Gmp Phosphodiesterases - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Basilar Artery - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Bradykinin - Pharmacology | en_US |
dc.subject.mesh | Cyclic Gmp - Biosynthesis | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Nitric Oxide - Pharmacology | en_US |
dc.subject.mesh | Purinones - Pharmacology | en_US |
dc.subject.mesh | Radioimmunoassay | en_US |
dc.subject.mesh | Subarachnoid Hemorrhage - Metabolism - Physiopathology | en_US |
dc.subject.mesh | Vasodilation | en_US |
dc.title | Reduced production of cGMP underlies the loss of endothelium-dependent relaxations in the canine basilar artery after subarachnoid hemorrhage | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.RES.70.2.248 | - |
dc.identifier.pmid | 1310445 | - |
dc.identifier.scopus | eid_2-s2.0-0026586194 | en_US |
dc.identifier.volume | 70 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 248 | en_US |
dc.identifier.epage | 256 | en_US |
dc.identifier.isi | WOS:A1992HC55400005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Kim, P=7402334666 | en_US |
dc.identifier.scopusauthorid | Schini, VB=7004113565 | en_US |
dc.identifier.scopusauthorid | Sundt Jr, TM=34572694400 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0009-7330 | - |