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- Publisher Website: 10.1111/j.1440-1681.1990.tb01356.x
- Scopus: eid_2-s2.0-0025148295
- PMID: 2170068
- WOS: WOS:A1990DX99300003
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Article: Changes in prejunctional potency of B-HT 933 during aging in the rat vas deferens
Title | Changes in prejunctional potency of B-HT 933 during aging in the rat vas deferens |
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Authors | |
Keywords | aging B‐HT 933 prejunctional receptors rat vas deferens. α 2‐adrenoceptors |
Issue Date | 1990 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1990, v. 17 n. 8, p. 557-565 How to Cite? |
Abstract | 1. Age-related changes in prejunctional α2-adrenoceptors were examined in the rat vas deferens using pharmacological techniques. 2. B-HT 933 (1x10-8-1x10-6 mol/L) caused a concentration-dependent inhibition of isometric contractions (tetrodotoxin-sensitive) induced by stimulation with single field-stimulus pulses, in both the epididymal and prostatic regions of rat vas deferens. The concentration-response curve to B-HT 933 was shifted to the right with age in the prostatic regions of the vas deferens. 3. In high concentrations (10-6-3x10-4 mol/L), B-HT 933 caused concentration-dependent enhancement of the contractile response to stimulation and evoked spontaneous contractile activity. No significant difference in this postjunctional activity occurred with age in either the prostatic or epididymal regions of the vas deferens. 4. Schild analysis revealed no significant differences in pA2 values for the antagonisms of the prejunctional inhibitory effect of B-HT 933 by rauwolscine in either the prostatic or epididymal regions of vas deferens between young and old rats. 5. These results could be interpreted as a decrease in α2-adrenoceptor number with age. The more marked decrease in the prejunctional inhibitory potency of B-HT 933 in prostatic regions of vas deferens with aging may be due to a smaller receptor reserve in this region of the vas deferens. |
Persistent Identifier | http://hdl.handle.net/10722/171542 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pagenkopf, CW | en_US |
dc.contributor.author | Bourreau, JP | en_US |
dc.contributor.author | Challice, CE | en_US |
dc.date.accessioned | 2012-10-30T06:15:36Z | - |
dc.date.available | 2012-10-30T06:15:36Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1990, v. 17 n. 8, p. 557-565 | en_US |
dc.identifier.issn | 0305-1870 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171542 | - |
dc.description.abstract | 1. Age-related changes in prejunctional α2-adrenoceptors were examined in the rat vas deferens using pharmacological techniques. 2. B-HT 933 (1x10-8-1x10-6 mol/L) caused a concentration-dependent inhibition of isometric contractions (tetrodotoxin-sensitive) induced by stimulation with single field-stimulus pulses, in both the epididymal and prostatic regions of rat vas deferens. The concentration-response curve to B-HT 933 was shifted to the right with age in the prostatic regions of the vas deferens. 3. In high concentrations (10-6-3x10-4 mol/L), B-HT 933 caused concentration-dependent enhancement of the contractile response to stimulation and evoked spontaneous contractile activity. No significant difference in this postjunctional activity occurred with age in either the prostatic or epididymal regions of the vas deferens. 4. Schild analysis revealed no significant differences in pA2 values for the antagonisms of the prejunctional inhibitory effect of B-HT 933 by rauwolscine in either the prostatic or epididymal regions of vas deferens between young and old rats. 5. These results could be interpreted as a decrease in α2-adrenoceptor number with age. The more marked decrease in the prejunctional inhibitory potency of B-HT 933 in prostatic regions of vas deferens with aging may be due to a smaller receptor reserve in this region of the vas deferens. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_US |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_US |
dc.subject | aging | - |
dc.subject | B‐HT 933 | - |
dc.subject | prejunctional receptors | - |
dc.subject | rat vas deferens. | - |
dc.subject | α 2‐adrenoceptors | - |
dc.subject.mesh | Aging - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Azepines - Administration & Dosage - Antagonists & Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Physiology | en_US |
dc.subject.mesh | Vas Deferens - Drug Effects - Physiology | en_US |
dc.subject.mesh | Yohimbine - Pharmacology | en_US |
dc.title | Changes in prejunctional potency of B-HT 933 during aging in the rat vas deferens | en_US |
dc.type | Article | en_US |
dc.identifier.email | Bourreau, JP:bourreau@hkucc.hku.hk | en_US |
dc.identifier.authority | Bourreau, JP=rp00389 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1681.1990.tb01356.x | - |
dc.identifier.pmid | 2170068 | - |
dc.identifier.scopus | eid_2-s2.0-0025148295 | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 557 | en_US |
dc.identifier.epage | 565 | en_US |
dc.identifier.isi | WOS:A1990DX99300003 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Pagenkopf, CW=6508375954 | en_US |
dc.identifier.scopusauthorid | Bourreau, JP=7003927886 | en_US |
dc.identifier.scopusauthorid | Challice, CE=7004068919 | en_US |
dc.identifier.issnl | 0305-1870 | - |